1.2.1.84: alcohol-forming fatty acyl-CoA reductase
This is an abbreviated version!
For detailed information about alcohol-forming fatty acyl-CoA reductase, go to the full flat file.
Word Map on EC 1.2.1.84
-
1.2.1.84
-
cuticular
-
cutin
-
stripak
-
jojoba
-
simmondsia
-
marinobacter
-
very-long-chain
-
drug development
- 1.2.1.84
- cuticular
- cutin
-
stripak
- jojoba
-
simmondsia
- marinobacter
-
very-long-chain
- drug development
Reaction
Synonyms
alcohol-forming FAR, alcohol-forming fatty acyl-CoA reductase, CER4, CG1443, FACR, FAR, FAR1, FAR10, FAR11, FAR12, FAR13, FAR14, FAR15, FAR16, FAR17, FAR2, FAR3, FAR4, FAR5, FAR6, FAR7, FAR8, FAR9, fatty acyl coenzyme A reductase, fatty acyl-CoA reductase, fatty acyl-CoA reductase 1, fatty acyl-CoA reductase 3, fatty acyl-CoA:NADPH oxidoreductase (long chain alcohol forming), fatty acyl-Coenzyme A reductase, FcrA, intestinal acyl-CoA reductase, male sterility C-terminal domain, male sterility domain-containing protein 1, Maqu_2220, Maqu_2507, Ms25, peroxisomal fatty acyl-CoA reductase 1, PsFAR I, PsFAR II, RS30405, wat, Waterproof
ECTree
1.2.1.84 alcohol-forming fatty acyl-CoA reductaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.2.1.84 - alcohol-forming fatty acyl-CoA reductase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(Z)-11-hexadecenoyl-CoA + 2 NADPH + 2 H+
(Z)-11-hexadecenal + CoA + 2 NADP+
-
-
-
?
2-methylhexadecanoyl-CoA + 2 NADPH + 2 H+
2-methylhexadecanol + 2 NADP+ + coenzyme A
low activity
-
-
?
2-methyloctadecanoyl-CoA + 2 NADPH + 2 H+
2-methyloctadecanol + 2 NADP+ + coenzyme A
low activity
-
-
?
a long-chain acyl-CoA + 2 NADPH + 2 H+
a long-chain alcohol + 2 NADP+ + CoA
Marinobacter nauticus
-
-
-
?
arachidonoyl-CoA + NADPH
cis-5,8,11,14-eicosatetraenal + NADP+ + CoA
low activity
-
-
?
arachidoyl-CoA + 2 NADPH + 2 H+
arachidol + 2 NADP+ + coenzyme A
low activity
-
-
?
decanoyl-CoA + 2 NADPH + 2 H+
decanol + 2 NADP+ + coenzyme A
low activity
-
-
?
eicosanoyl-CoA + 2 NADPH + 2 H+
1-eicosanol + CoA + 2 NADP+
-
-
-
-
?
eicosenoyl-CoA + 2 NADPH + 2 H+
eicosanol + 2 NADP+ + coenzyme A
higher activity
-
-
?
eicosenoyl-CoA + NADPH + H+
eicosenyl alcohol + NADP+
about 50% of the activity with stearoyl-CoA
-
-
?
erucoyl-CoA + NADPH + H+
erucyl alcohol + NADP+
about 30% of the activity with stearoyl-CoA
-
-
?
erucyl-CoA + 2 NADPH + 2 H+
erucyl alcohol + 2 NADP+ + coenzyme A
moderate activity
-
-
?
hexacosanoyl-CoA + 2 NADPH + 2 H+
hexacosanoyl alcohol + 2 NADP+ + coenzyme A
-
-
-
?
hexacosanoyl-CoA + 2 NADPH + 2 H+
hexacosanoyl alcohol + CoA + 2 NADP+
-
-
-
-
?
hexacosanoyl-CoA + NADPH + H+
hexacosanoyl alcohol + CoA + NADP+
-
-
-
?
hexadecenoyl-CoA + 2 NADPH + 2 H+
hexadecenol + CoA + 2 NADP+
-
-
-
?
homo-gamma-linolenoyl-CoA + NADPH
? + NADP+ + CoA
low activity
-
-
?
lauroyl-CoA + 2 NADPH + 2 H+
dodecanol + 2 NADP+ + coenzyme A
low activity
-
-
?
linoleoyl-CoA + NADPH
cis-9,12-octadecadienal + NADP+ + CoA
-
-
-
?
myristoyl-CoA + 2 NADPH + 2 H+
myristol + 2 NADP+ + coenzyme A
low activity
-
-
?
oleoyl-CoA + 2 NADPH + 2 H+
octadecenol + 2 NADP+ + coenzyme A
low activity
-
-
?
palmitoleoyl-CoA + 2 NADPH + 2 H+
palmitoleic alcohol + CoA + 2 NADP+
-
-
-
-
?
ricinoleoyl-CoA + 2 NADPH + 2 H+
(9Z,12R)-octadec-9-ene-1,12-diol + 2 NADP+ + coenzyme A
low activity
-
-
?
stearoyl-CoA + 2 NADPH + 2 H+
octadecanol + 2 NADP+ + coenzyme A
best substrate
-
-
?
tetracosanoyl-CoA + 2 NADPH + 2 H+
tetracosanoyl alcohol + 2 NADP+ + coenzyme A
-
-
-
?
tetracosanoyl-CoA + NADPH + H+
tetracosanoyl alcohol + CoA + NADP+
-
-
-
?
tetradecenoyl-CoA + 2 NADPH + 2 H+
tetradecenol + CoA + 2 NADP+
-
-
-
?
a long-chain acyl-CoA + 2 NADPH + 2 H+
a long-chain alcohol + 2 NADP+ + coenzyme A
-
-
-
?
a long-chain acyl-CoA + 2 NADPH + 2 H+
a long-chain alcohol + 2 NADP+ + coenzyme A
Marinobacter nauticus
-
-
-
?
a long-chain acyl-CoA + 2 NADPH + 2 H+
a long-chain alcohol + 2 NADP+ + coenzyme A
-
-
-
?
a long-chain acyl-CoA + 2 NADPH + 2 H+
a long-chain alcohol + 2 NADP+ + coenzyme A
-
-
-
?
docosanoyl-CoA + 2 NADPH + 2 H+
1-docosanol + CoA + 2 NADP+
-
-
-
?
docosanoyl-CoA + 2 NADPH + 2 H+
1-docosanol + CoA + 2 NADP+
-
-
-
-
?
docosanoyl-CoA + 2 NADPH + 2 H+
1-docosanol + CoA + 2 NADP+
preferred substrate for isoform FAR1
-
-
?
hexacosanoyl-CoA + 2 NADPH + 2 H+
1-hexacosanol + CoA + 2 NADP+
-
-
-
?
hexacosanoyl-CoA + 2 NADPH + 2 H+
1-hexacosanol + CoA + 2 NADP+
preferred substrate for isoform FAR3
-
-
?
hexacosanoyl-CoA + 2 NADPH + 2 H+
1-hexacosanol + CoA + 2 NADP+
-
-
-
?
hexacosanoyl-CoA + 2 NADPH + 2 H+
1-hexacosanol + CoA + 2 NADP+
preferred substrate for isoform FAR2
-
-
?
hexacosanoyl-CoA + 2 NADPH + 2 H+
1-hexacosanol + CoA + 2 NADP+
preferred substrate for isoform FAR3
-
-
?
hexadecanoyl-CoA + 2 NADPH + 2 H+
1-hexadecanol + CoA + 2 NADP+
-
-
-
?
hexadecanoyl-CoA + 2 NADPH + 2 H+
1-hexadecanol + CoA + 2 NADP+
preferred substrate for isoform FAR1
-
-
?
hexadecanoyl-CoA + 2 NADPH + 2 H+
hexadecanol + CoA + 2 NADP+
-
-
-
?
octacosanoyl-CoA + 2 NADPH + 2 H+
1-octacosanol + CoA + 2 NADP+
-
-
-
?
octacosanoyl-CoA + 2 NADPH + 2 H+
1-octacosanol + CoA + 2 NADP+
preferred substrate for isoform FAR6
-
-
?
octadecanoyl-CoA + 2 NADPH + 2 H+
1-octadecanol + CoA + 2 NADP+
-
-
-
?
octadecanoyl-CoA + 2 NADPH + 2 H+
1-octadecanol + CoA + 2 NADP+
preferred substrate for isoform FAR2
-
-
?
palmitoyl-CoA + 2 NADPH + 2 H+
hexadecanol + 2 NADP+ + coenzyme A
-
-
-
?
palmitoyl-CoA + 2 NADPH + 2 H+
hexadecanol + 2 NADP+ + coenzyme A
lower activity
-
-
?
tetracosanoyl-CoA + 2 NADPH + 2 H+
1-tetracosanol + CoA + 2 NADP+
-
-
-
?
tetracosanoyl-CoA + 2 NADPH + 2 H+
1-tetracosanol + CoA + 2 NADP+
preferred substrate for isoform FAR4
-
-
?
tetracosanoyl-CoA + 2 NADPH + 2 H+
1-tetracosanol + CoA + 2 NADP+
-
-
-
?
additional information
?
-
Waterproof is a Drosophila FAR with a preference for very long chain, saturated fatty acids of 24 and 26 carbons. In yeast cultures expressing Waterproof, tetracosanoyl-alcohol (24:0-OH) and hexacosanoyl-alcohol (26:0-OH) are identified by GC/MS analysis, unsaturated alcohols or alcohols of shorter chain-lengths are either absent or below the detection limit. Neither of these fatty alcohols is detected in the vector control yeast culture or the wat gene containing culture grown under non-inducing conditions
-
-
?
additional information
?
-
no activity with (Z)-11-octadecenoyl-CoA and (Z)-9-oleoyl-CoA
-
-
-
additional information
?
-
no activity with oleoyl-CoA, linoleoyl-CoA, homo-gamma-linoleoyl-CoA or arachidonoyl-CoA
-
-
?
additional information
?
-
no activity with oleoyl-CoA, linoleoyl-CoA, homo-gamma-linoleoyl-CoA or arachidonoyl-CoA
-
-
?
additional information
?
-
isoform FAR1 prefers C16, C18, C18:1, and C18:2 fatty acids and is less active against other lipids
-
-
?
additional information
?
-
isoform FAR1 prefers C16, C18, C18:1, and C18:2 fatty acids and is less active against other lipids
-
-
?
additional information
?
-
isoform FAR2 prefers saturated C16 and C18 fatty acids
-
-
?
additional information
?
-
isoform FAR2 prefers saturated C16 and C18 fatty acids
-
-
?
additional information
?
-
-
no activity is detected when NADPH is substituted with NADH
-
-
-
additional information
?
-
enzyme substrate specificity, overview. Poor activity with linoleoyl-CoA and linolenoyl-CoA
-
-
?
