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1.2.1.70: glutamyl-tRNA reductase

This is an abbreviated version!
For detailed information about glutamyl-tRNA reductase, go to the full flat file.

Word Map on EC 1.2.1.70

Reaction

L-glutamate 1-semialdehyde
+
NADP+
+
tRNAGlu
=
L-glutamyl-tRNAGlu
+
NADPH
+
H+

Synonyms

AtHEMA1, EC 2.7.2.13, GluRS, glutamate tRNA reductase, glutamate-specific tRNA reductase, glutamyl transfer RNA reductase, glutamyl-tRNA reductase, GluTR, GluTR1, GTR, GtrR, hemA, HEMA1, HEMA2, reductase, glutamyl-transfer ribonucleate, ZjGluTR

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.70 glutamyl-tRNA reductase

Inhibitors

Inhibitors on EC 1.2.1.70 - glutamyl-tRNA reductase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
5 mM, 25% inhibition
2,2'-dipyridyl
-
5 mM, 20% inhibition
2,4-diphenyl-6-styryl-1-p-tolyl-pyridinium boron tetrafluoride
-
IC50: 0.01 mM
4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
-
IC50: 0.055 mM
5,5'-dithiobis(2-nitrobenzoic acid)
5,5'-dithiobis-(2-nitrobenzoic acid)
-
-
5,6-dichloro-1,3-benzodioxol-2-one
-
IC50: 0.055 mM
Cd2+
-
1 mM Cd(Ac)2, 92% inhibition
Cu2+
-
1 mM CuCl2, 84% inhibition
EDTA
-
10 mM, 55% inhibition
EGTA
-
10 mM, 35% inhibition
Fe2+
-
5 mM FeSO4, 66% inhibition
Fe3+
-
10 mM FeCl3, 80% inhibition
fluorescent in blue light
-
FLU, the protein mediates inactivation of the enzyme at the membrane
-
glutamate 1-semialdehyde
-
0.2 mM, 50% inhibition
glutamate-1-semialdehyde
1.0 mM, 50% inhibition
glutamycin
H2O2
inactivates the enzyme. H2O2 decreases the stimulation of GluTR by glutamate semialdehyde 1-2 aminomutase, GSAM
hemin
50% inhibition at 0.0015 mM
iodoacetamide
N-tosyl-L-phenylalaninechloromethyl ketone
0.1 mM, 90% inhibition, 1.0 mM, complete inhibition
PbCl2
0.1 mM, 60% inhibition, 1.0 mM, complete inhibition
protein FLU
-
protein GBP
a soluble GluTR-binding protein, enzyme binding structure, overview. the GluTR-GBP complex is stable and has a low apparent dissociation constant. Protein GBP is initially found in chloroplast stroma
-
PtCl4
Zn2+
-
2.5 mM, ZnSO4, 94% inhibition
ZnCl2
0.2 mM, 45% inhibition, 5.0 mM, 90% inhibition
additional information
structure analysis of the FLUTPR-GluTR-GBP ternary complex, overview. Three mechanisms for plant GluTR activity regulation: (i) the end-product feedback inhibition by heme, (ii) repression by a membrane protein FLUORESCENT (FLU), and (iii) formation of complex with a soluble GluTR-binding protein (GBP)
-