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1.2.1.70: glutamyl-tRNA reductase

This is an abbreviated version!
For detailed information about glutamyl-tRNA reductase, go to the full flat file.

Word Map on EC 1.2.1.70

Reaction

L-glutamate 1-semialdehyde
+
NADP+
+
tRNAGlu
=
L-glutamyl-tRNAGlu
+
NADPH
+
H+

Synonyms

AtHEMA1, EC 2.7.2.13, GluRS, glutamate tRNA reductase, glutamate-specific tRNA reductase, glutamyl transfer RNA reductase, glutamyl-tRNA reductase, GluTR, GluTR1, GTR, GtrR, hemA, HEMA1, HEMA2, reductase, glutamyl-transfer ribonucleate, ZjGluTR

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.70 glutamyl-tRNA reductase

Crystallization

Crystallization on EC 1.2.1.70 - glutamyl-tRNA reductase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
purified GluTR in complex with GluBP, X-ray diffraction structure determination and analysis at 2.8 A resolution, modeling
purified recombinant GluTR in ternary complex with GBP and FLUTPR, the protein are mixed at molar ratio of 2:3:3, X-ray diffraction structure determination and analysis at 3.2 A resolution, molecular replacement method
uncomplexed TPR domain of FLU (FLUTPR) and complex of the dimeric domain of GluTR bound to FLUTPR, hanging drop vapor diffusion method, from 0.2 M NaCl, 0.1 M Bis-Tris, pH 6.5, and 25% w/v PEG 3350 in 1 week, and from 0.15 M KBr and 30% w/v PEG monomethyl ether 2000, in 3 weeks, X-ray diffraction structure determination and analysis at 1.45 and 2.4 A resolution, respectively, molecular replacement and modeling
crystallized in presence of glutamycin, the structure is solved by the multiple isomorphous replacement method using three heavy atom derivatives. The structure is subsequently refined at a resolution of 1.95 A
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