1.2.1.49: 2-oxoaldehyde dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about 2-oxoaldehyde dehydrogenase (NADP+), go to the full flat file.
Reaction
Synonyms
2-ketoaldehyde dehydrogenase, alpha-ketoaldehyde dehydrogenase, methylglyoxal dehydrogenase, NADP-dependent alpha-ketoaldehyde dehydrogenase, NADP-linked alpha-ketoaldehyde dehydrogenase
ECTree
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Substrates Products
Substrates Products on EC 1.2.1.49 - 2-oxoaldehyde dehydrogenase (NADP+)
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REACTION DIAGRAM
2-keto-3-deoxy-D-glucose + NADP+ + H2O
2-keto-3-deoxy-D-gluconate + NADPH + H+
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r
2-keto-3-deoxy-D-gluconic acid + NADPH + H+
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?
2-keto-3-deoxy-D-glucose + NADP+ + H2O
2-keto-3-deoxy-D-gluconic acid + NADPH + H+
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?
2-oxoaldehydes + NADP+ + H2O
2-oxo acids + NADPH
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enzyme from sheep or rat liver also active with NAD+, see also EC 1.2.1.23
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?
2-oxoaldehydes + NADP+ + H2O
2-oxo acids + NADPH
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enzyme from sheep or rat liver also active with NAD+, see also EC 1.2.1.23
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?
2-oxoaldehydes + NADP+ + H2O
2-oxo acids + NADPH
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enzyme from sheep or rat liver also active with NAD+, see also EC 1.2.1.23
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?
2-oxoaldehydes + NADP+ + H2O
2-oxo acids + NADPH
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enzyme from sheep or rat liver also active with NAD+, see also EC 1.2.1.23
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?
2-oxoaldehydes + NADP+ + H2O
2-oxo acids + NADPH
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enzyme from sheep or rat liver also active with NAD+, see also EC 1.2.1.23
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?
methylglyoxal + NADP+ + H2O
pyruvate + NADPH
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contributes to the detoxification of methylglyoxal
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the presence of L-2-aminopropan-1-ol is necessary to activate the enzyme
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additional information
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the presence of L-2-aminopropan-1-ol is necessary to activate the enzyme
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additional information
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the presence of amines like Tris, 2-amino-2-methylpropane-1,3-diol, 2-amino-2-methylpropan-1-ol, 2-aminopropane-1,3-diol, 2-aminopropane or 2-aminobutan-1-ol is necessary to activate the enzyme
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additional information
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L-serine methyl ester or L-2-aminopropan-1-ol are necessary to activate the enzyme
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additional information
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the only known amine which activates the enzyme at physiological pH is L-serine methyl ester, L-2-amino-1-propanol gives very little activity but D,L-2-amino-1-propanol activates the enzyme
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?