1.2.1.47: 4-trimethylammoniobutyraldehyde dehydrogenase

This is an abbreviated version!
For detailed information about 4-trimethylammoniobutyraldehyde dehydrogenase, go to the full flat file.

Word Map on EC 1.2.1.47

1.2.1.47

gamma-butyrobetaine

proliferator-activated

dioxygenase

peroxisome

l-carnitine

polyunsaturated

1.2.1.8

badhs

aldh4a1

suckling

gill

betaine

acetaldehyde

trimethyllysine

Reaction

+ 2 H+

Synonyms

4-N-trimethylaminobutyraldehyde dehydrogenase, 4-N-trimethylaminobutyraldehyde dehydrogenase II, 4-trimethylaminobutyraldehyde dehydrogenase, 4-trimethylammoniobutyraldehyde dehydrogenase, aldehyde dehydrogenase 9A1, Aldh9a1, carnitine biosynthesis enzyme, dehydrogenase, trimethylaminobutyraldehyde, gamma-trimethylaminobutyraldehyde dehydrogenase, TMABA dehydrogenase, TMABA-DH, TMABADH, TMABAL dehydrogenase, TMABaldehyde-DH II, TMABALDH

ECTree

1 Oxidoreductases

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.1.47 4-trimethylammoniobutyraldehyde dehydrogenase

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Results	in table
1	Activating Compound
30	AA Sequence
1	Application
1	CAS Registry Number
5	Cloned(Commentary)
16	Cofactor
2	Crystallization (Commentary)
9	Disease/ Diagnostics
3	Expression
6	General Information
1	General Stability
44	Inhibitors
5	Ki Value [mM]
36	KM Value [mM]
8	Localization
1	Metals/Ions
9	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
19	Organism
5	Pathway
30	PDB ID
6	pH Optimum
1	pH Range
2	pH Stability
2	pI Value
7	Purification (Commentary)
1	Reaction
4	Reaction Type
18	Reference
54	Source Tissue
16	Specific Activity [micromol/min/mg]
3	Storage Stability
69	Substrates and Products (Substrate)
11	Subunits
36	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
3	Temperature Stability [°C]

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Reference on EC 1.2.1.47 - 4-trimethylammoniobutyraldehyde dehydrogenase

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288254

Hulse, J.D.; Henderson, L.M.

Carnitine biosynthesis. Purification of 4-N-trimethylaminobutyraldehyde dehydrogenase from beef liver

J. Biol. Chem.

255

1146-1151

1980

Bos taurus

7356654

288255

Vaz, F.M.; Fouchier, S.W.; Ofman, R.; Sommer, M.; Wanders, R.J.A.

Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis

J. Biol. Chem.

275

7390-7394

2000

Rattus norvegicus (Q9JLJ3), Rattus norvegicus Wistar (Q9JLJ3)

10702312

671302

van Vlies, N.; Wanders, R.J.; Vaz, F.M.

Measurement of carnitine biosynthesis enzyme activities by tandem mass spectrometry: differences between the mouse and the rat

Anal. Biochem.

354

132-139

2006

Mus musculus, Rattus norvegicus

16707092

689379

Marchitti, S.A.; Deitrich, R.A.; Vasiliou, V.

Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase

Pharmacol. Rev.

125-150

2007

Homo sapiens (P49189)

17379813

690142

Alnouti, Y.; Klaassen, C.D.

Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice

Toxicol. Sci.

101

51-64

2008

Mus musculus (Q9JLJ2)

17998271

691376

Hassan, M.; Okada, M.; Ichiyanagi, T.; Mori, N.

4-N-trimethylaminobutyraldehyde dehydrogenase: purification and characterization of an enzyme from Pseudomonas sp. 13CM

Biosci. Biotechnol. Biochem.

155-162

2008

Pseudomonas sp., Pseudomonas sp. 13CM

18175913

699966

Garcia-Delgado, M.; Peral, M.J.; Duran, J.M.; Garcia-Miranda, P.; Calonge, M.L.; Ilundain, A.A.

Ontogeny of Na(+)/L-carnitine transporter and of gamma-trimethylaminobutyraldehyde dehydrogenase and gamma-butyrobetaine hydroxylase genes expression in rat kidney

Mech. Ageing Dev.

130

227-233

2009

Rattus norvegicus (Q9JLJ3)

19150623

724438

Wen, G.; Ringseis, R.; Rauer, C.; Eder, K.

The mouse gene encoding the carnitine biosynthetic enzyme 4-N-trimethylaminobutyraldehyde dehydrogenase is regulated by peroxisome proliferator-activated receptor alpha

Biochim. Biophys. Acta

1819

357-365

2012

Mus musculus (Q9JLJ2), Mus musculus

22285688

726537

Bari, M.R.; Hassan, M.; Akai, N.; Arima, J.; Mori, N.

Gene cloning and biochemical characterization of 4-N-trimethylaminobutyraldehyde dehydrogenase II from Pseudomonas sp. 13CM

World J. Microbiol. Biotechnol.

683-692

2013

Pseudomonas sp. (N0DT23), Pseudomonas sp., Pseudomonas sp. 13CM (N0DT23)

23225139

743576

Matsunaga, A.; Harita, Y.; Shibagaki, Y.; Shimizu, N.; Shibuya, K.; Ono, H.; Kato, H.; Sekine, T.; Sakamoto, N.; Igarashi, T.; Hattori, S.

Identification of 4-trimethylaminobutyraldehyde dehydrogenase (TMABA-DH) as a candidate serum autoantibody target for Kawasaki disease

PLoS ONE

e0128189

2015

Homo sapiens (P49189), Homo sapiens, Rattus norvegicus (Q9JLJ3)

26010099

762675

Wyatt, J.W.; Korasick, D.A.; Qureshi, I.A.; Campbell, A.C.; Gates, K.S.; Tanner, J.J.

Inhibition, crystal structures, and in-solution oligomeric structure of aldehyde dehydrogenase 9A1

Arch. Biochem. Biophys.

691

108477

2020

Homo sapiens (P49189), Homo sapiens

32717224

762831

Koncitikova, R.; Vigouroux, A.; Kopecna, M.; Sebela, M.; Morera, S.; Kopecny, D.

Kinetic and structural analysis of human ALDH9A1

Biosci. Rep.

BSR20190558

2019

Homo sapiens (P49189), Homo sapiens

30914451

763484

Almannai, M.; Alfadhel, M.; El-Hattab, A.W.

Carnitine inborn errors of metabolism

Molecules

3251

2019

Homo sapiens

31500110