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1.2.1.44: cinnamoyl-CoA reductase

This is an abbreviated version!
For detailed information about cinnamoyl-CoA reductase, go to the full flat file.

Word Map on EC 1.2.1.44

Reaction

cinnamaldehyde
+
CoA
 +
NADP+
=
cinnamoyl-CoA
 +
NADPH
 +
H+

Synonyms

AtCCR1, BpCCR1, CCR, CCR1, CCR12, CCR14 isoform, CCR17, CCR19, CCR2, CCR2-1, CCR20, CCR21, CCR3, CCR7, CCRH1, cinnamoyl CoA reductase, cinnamoyl CoA reductase 1, cinnamoyl coenzyme A reductase, cinnamoyl-Co-enzyme A reductase, cinnamoyl-CoA reductase, cinnamoyl-CoA reductase 1, cinnamoyl-CoA reductase1, cinnamoyl-CoA reductase2, cinnamoyl-CoA:NADPH reductase, cinnamoyl-coenzyme A reductase, cinnamoyl-coenzyme A reductase 1, FaCCR, feruloyl coenzyme A reductase, feruloyl-CoA reductase, ferulyl-CoA reductase, HcCCR1, HcCCR2, Ll-CCRH1, OsCCR1, p-hydroxycinnamoyl coenzyme A reductase, Ph-CCR1, PtCCR, PtoCCR1, PtoCCR7, PvCCR1, PvCCR2, reductase, cinnamoyl coenzyme A, SbCCR1, SbCCR2-1, SbCCR2-2, Ta-CCR2, VcCCR

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.44 cinnamoyl-CoA reductase

Inhibitors

Inhibitors on EC 1.2.1.44 - cinnamoyl-CoA reductase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
-
4-chloromercuribenzoate
5-hydroxyferuloyl-CoA
Ca2+
-
86% residual activity at 2 mM
caffeoyl-CoA
competitive inhibitor
citraconic anhydride
31% residual activity at 1.5 mM with feruloyl-CoA as substrate
Co2+
-
42% residual activity at 2 mM
CoASH
-
product inhibition
Cs2+
-
83% residual activity at 2 mM
Cu2+
-
49% residual activity at 2 mM
diethylpyrocarbonate
44% residual activity at 3 mM with feruloyl-CoA as substrate
Fe2+
-
92% residual activity at 2 mM
feruloyl-CoA
Hg2+
-
complete inhibition at 2 mM
iodoacetamide
-
1 mM, 50% inhibition
Mg2+
-
74% residual activity at 2 mM
Mn2+
-
21% residual activity at 2 mM
N-acetyl imidazole
50% residual activity at 3 mM with feruloyl-CoA as substrate
N-ethylmaleimide
-
-
NADP+
-
product inhibition
Ni2+
-
25% residual activity at 2 mM
Phenylglyoxal
47% residual activity at 1 mM with feruloyl-CoA as substrate
phenylmethylsulfonyl fluoride
60% residual activity at 1 mM with feruloyl-CoA as substrate
S-[2-(acetylamino)ethyl] O-ethyl [(E)-2-(3,4-dimethoxyphenyl)ethenyl]phosphonothioate
-
-
S-[2-(acetylamino)ethyl] O-ethyl [(E)-2-(4-hydroxy-3,5-dimethoxyphenyl)ethenyl]phosphonothioate
-
-
S-[2-(acetylamino)ethyl] O-ethyl [(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]phosphonothioate
-
-
S-[2-(acetylamino)ethyl] O-ethyl [(E)-2-(4-hydroxyphenyl)ethenyl]phosphonothioate
-
-
S-[2-(acetylamino)ethyl] O-ethyl [(E)-2-(4-methoxyphenyl)ethenyl]phosphonothioate
-
-
SDS
-
6% residual activity at 1% (v/v)
sinapoyl-CoA
competitive inhibitor
Woodward's reagent K
54% residual activity at 0.02 mM with feruloyl-CoA as substrate
Zn2+
-
45% residual activity at 2 mM
additional information
-