1.2.1.36: retinal dehydrogenase
This is an abbreviated version!
For detailed information about retinal dehydrogenase, go to the full flat file.
Word Map on EC 1.2.1.36
-
1.2.1.36
-
retinoic
-
raldhs
-
mesoderm
-
dendritic
-
all-trans
-
aldh1a2
-
ventral
-
ra-synthesizing
-
all-trans-retinoic
-
cyp26s
-
hindbrain
-
retinol-binding
-
somite
-
anterior-posterior
-
gut-homing
-
otic
-
crabps
-
ra-dependent
-
ra-responsive
-
molecular biology
-
somitogenesis
-
all-trans-retinal
-
rhombomere
-
synthesis
-
acid-synthesizing
-
diagnostics
-
dorsoventral
-
epicardium
-
degradation
-
citral
-
anteroposterior
-
paraxial
-
ra-mediated
-
rarbeta
-
retinyl
-
retinoid-dependent
-
medicine
-
foxp3+
-
raralpha
- 1.2.1.36
-
retinoic
- raldhs
- mesoderm
- dendritic
-
all-trans
- aldh1a2
-
ventral
-
ra-synthesizing
-
all-trans-retinoic
-
cyp26s
- hindbrain
-
retinol-binding
- somite
-
anterior-posterior
-
gut-homing
-
otic
-
crabps
-
ra-dependent
-
ra-responsive
- molecular biology
-
somitogenesis
- all-trans-retinal
-
rhombomere
- synthesis
-
acid-synthesizing
- diagnostics
-
dorsoventral
-
epicardium
- degradation
- citral
-
anteroposterior
-
paraxial
-
ra-mediated
-
rarbeta
-
retinyl
-
retinoid-dependent
- medicine
-
foxp3+
-
raralpha
Reaction
Synonyms
aldehyde dehydrogenase 1, aldehyde dehydrogenase 1A1, aldehyde dehydrogenase 1A2, aldehyde dehydrogenase 1A3, ALDH 1A1, ALDH 1A2, ALDH class 1, ALDH-1A1, ALDH-3A1, ALDH1, ALDH1A1, Aldh1a2, Aldh1a3, BcALDH, cytosolic retinal dehydrogenase, dehydrogenase, retinal, dehydrogenase/reductase member 3, DHRS3, ETA-crystallin, More, NAD+-dependent aldehyde dehydrogenase, NAD-dependent retinal dehydrogenase, NAD-dependent retinal dehydrogenases, PB-RALDH, phenobarbital-induced aldehyde dehydrogenase, RALDH, RALDH-1, RALDH-3, RalDH1, RALDH1A1, RALDH2, RALDH3, Raldh4, RDH12, RDH13, RDH5, retialdehyde dehydrogenase, Retinal dehydrogenase, retinal dehydrogenase 1, retinal dehydrogenase 2, retinal dehydrogenase 3, retinal dehydrogenase 4, retinal dehydrogenase 5, retinal dehydrogenase type-2, retinal dehydrogenase-2, retinal dehydrogenase/reductase, retinal short-chain dehydrogenase/reductase, retinalaldehyde dehydrogenase 2, retinaldehyde dehydrogenase, retinaldehyde dehydrogenase 1, retinaldehyde dehydrogenase 2, retinaldehyde dehydrogenase 3, retinaldehyde dehydrogenase type II, retinaldehyde dehydrogenase type-1, retinaldehyde dehydrogenase-2, retinaldehyde dehydrogenases, retinol dehydrogenase 13, retSDR1, testis-specific aldehyde dehydrogenase, thyroid-hormone-binding protein, type 2 retinaldehyde dehydrogenase, xCTBP, xCTBP/xALDH1, zRalDH
ECTree
1.2.1.36 retinal dehydrogenaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 1.2.1.36 - retinal dehydrogenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
all-trans retinal + NAD+ + H2O
all-trans retinoate + NADH + 2 H+
-
-
-
?
all-trans-retinal + NAD+ + H2O
all-trans-retinoic acid + NADH
-
key enzyme in retinoic acid biosynthesis, essential in developing diaphragm, enzyme inhibition or disfunction causes the serious developmental anomaly congenital diaphragmatic hernia, i.e. CDH
-
-
?
9-cis-retinal + NAD+ + H2O
9-cis-retinoate + NADH
-
step in biosynthesis of vitamin A, transduction by nuclear retinoid receptors, required for ontogenesis and homeostasis of numerous tissues
-
-
?
all-trans-retinal + H2O + NAD+
all-trans-retinoate + NADH + 2 H+
-
-
-
?
all-trans-retinal + H2O + NAD+
all-trans-retinoate + NADH + 2 H+
-
-
-
?
all-trans-retinal + H2O + NAD+
all-trans-retinoate + NADH + 2 H+
-
-
-
?
all-trans-retinal + NAD+ + H2O
all-trans-retinoate + NADH
-
second step in retinol clearance in adult mice, null mutants show retinol clearance reduced by 7%, and a lower LD50 concentration for all-trans-retinol compared to the wild-type mice
-
-
?
all-trans-retinal + NAD+ + H2O
all-trans-retinoate + NADH
-
step in biosynthesis of vitamin A, transduction by nuclear retinoid receptors, required for ontogenesis and homeostasis of numerous tissues
-
-
?
all-trans-retinal + NAD+ + H2O
all-trans-retinoate + NADH
-
type-2 isozyme
-
-
?
all-trans-retinal + NAD+ + H2O
all-trans-retinoate + NADH + 2 H+
-
-
-
?
all-trans-retinal + NAD+ + H2O
all-trans-retinoate + NADH + 2 H+
-
-
-
?
all-trans-retinal + NAD+ + H2O
all-trans-retinoate + NADH + 2 H+
-
-
-
?
retinal + NAD+ + H2O
retinoate + NADH
-
a null mutation of RALDH2 is embryonic lethal, eliminating most mesodermal synthesis of retinoic acid. Loss of RALDH1 eliminates synthesis od retinoic acid only in the embryonic dorsal retina with no obvious effect on development
-
-
?
retinal + NAD+ + H2O
retinoate + NADH
-
acts on both the all-trans- and 13-cis-form of retinal, all-trans retinal more actively oxidized than 13-cis retinal
-
ir
retinal + NAD+ + H2O
retinoate + NADH
-
acts on both the all-trans- and 13-cis-form of retinal, all-trans retinal more actively oxidized than 13-cis retinal
-
ir
retinal + NAD+ + H2O
retinoate + NADH + 2 H+
-
-
-
?
additional information
?
-
-
enzyme is involved in retinoic acids biosynthesis, which are important signaling molecules in embryogenesis and tissue differentiation
-
-
?
additional information
?
-
-
physiological function, newborn lethal defect due to isozyme type-3 inactivation is prevented by maternal retinoic acid treatment, overview
-
-
?
additional information
?
-
-
type-2 isozyme catalyzes the last step in biosynthesis of retinoic acid in embryos and adult reproductive organs, isozyme type-2 regulates the retinoic acid level during embryogenesis and tissue differentiation
-
-
?
additional information
?
-
-
the enzyme xCTBP/xALDH1 binds T3 within living cells
-
-
?
