1.2.1.32: aminomuconate-semialdehyde dehydrogenase

This is an abbreviated version!
For detailed information about aminomuconate-semialdehyde dehydrogenase, go to the full flat file.

Word Map on EC 1.2.1.32

1.2.1.32

catechols

putida

meta-cleavage

hydratase

4-oxalocrotonate

2-aminophenols

toluate

m-cresol

3-methylcatechol

4-hydroxy-2-oxovalerate

nitrobenzene

comamonas

xylf

extradiol

chloroaromatics

isofunctional

Reaction

Synonyms

2-aminomuconate semialdehyde dehydrogenase, 2-aminomuconate-6-semialdehyde dehydrogenase, 2-aminomuconic 6-semialdehyde dehydrogenase, 2-AMS dehydrogenase, 2-hydroxy-5-methyl-6-oxohexa-2,4-dienoate dehydrogenase, 2-hydroxymuconate semialdehyde dehydrogenase, 2-hydroxymuconic 6-semialdehyde dehydrogenase, 2-hydroxymuconic acid semialdehyde dehydrogenase, 2-hydroxymuconic semialdehyde dehydrogenase, aldehyde dehydrogenase, ALDH12, Aldh8a1, alpha-aminomuconic epsilon-semialdehyde dehydrogenase, alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase, AMDH, aminomuconate semialdehyde dehydrogenase, aminomuconate-semialdehyde dehydrogenase, AMSDH, dehydrogenase, 2-hydroxymuconate semialdehyde, dehydrogenase, aminomuconate semialdehyde, HMSD-2, nbaE

ECTree

1 Oxidoreductases

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.1.32 aminomuconate-semialdehyde dehydrogenase

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Results	in table
1	Activating Compound
339	AA Sequence
1	Application
1	CAS Registry Number
13	Cloned(Commentary)
21	Cofactor
1	Crystallization (Commentary)
7	General Information
22	Inhibitors
2	kcat/KM [mM/s]
2	Ki Value [mM]
38	KM Value [mM]
12	Molecular Weight [Da]
25	Natural Substrates/ Products (Substrates)
152	Organism
9	Pathway
2	PDB ID
6	pH Optimum
2	pH Range
1	pI Value
10	Protein Variants
14	Purification (Commentary)
3	Reaction
7	Reaction Type
42	Reference
4	Source Tissue
11	Specific Activity [micromol/min/mg]
1	Storage Stability
127	Substrates and Products (Substrate)
12	Subunits
34	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
5	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 1.2.1.32 - aminomuconate-semialdehyde dehydrogenase

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2-aminomuconate 6-semialdehyde + NAD+ + H2O

2-aminomuconate + NADH + 2 H+

7 entries

2-aminomuconate 6-semialdehyde + NAD+ + H2O

2-aminomuconate + NADH + H+

3 entries

2-aminomuconate-6-semialdehyde + NAD+ + H2O

2-aminomuconate + NADH

10 entries

2-aminomuconic acid semialdehyde + NAD+ + H2O

2-aminomuconate + NADH + H+

Comamonas sp. JS765

675224

2-fluorobenzaldehyde + NAD+ + H2O

2-fluorobenzoate + NADH + H+

2 entries

2-hydroxy-5-methyl-6-oxohexa-2,4-dienoate + NAD+ + H2O

2-hydroxy-5-methylmuconate + NADH

4 entries

2-hydroxy-5-methyl-muconic-6-semialdehyde + NAD+

2-hydroxy-5-methylmuconate + NADH

2 entries

2-hydroxymuconate 6-semialdehyde + NAD+ + H2O

2-hydroxymuconate + NADH + 2 H+

Homo sapiens

Q9H2A2

763259

2-hydroxymuconate-6-semialdehyde + NAD+ + H2O

2-hydroxymuconate + NADH

9 entries

2-hydroxymuconate-6-semialdehyde + NAD+ + H2O

4-oxalocrotonate + NADH + H+

4 entries

2-hydroxymuconic 6-semialdehyde + NAD+ + H2O

2-hydroxymuconate + NADH + H+

Bordetella sp.

substrate for spectrophotometric activity assay, relative activity 100%

672682

2-hydroxymuconic acid semialdehyde + NAD+ + H2O

2-hydroxymuconate + NADH + H+

13 entries

2-nitrobenzaldehyde + NAD+ + H2O

2-nitrobenzoate + NADH + H+

Pseudomonas putida

390259

3-chlorobenzaldehyde + NAD+ + H2O

3-chlorobenzoate + NADH

Pseudomonas putida

low activity

389581, 390225, 390259

3-fluorobenzaldehyde + NAD+ + H2O

3-fluorobenzoate + NADH + H+

Pseudomonas putida

low activity

390225, 390259

3-methoxybenzaldehyde + NAD+ + H2O

3-methoxybenzoate + NADH

Pseudomonas putida

low activity

390225, 390259

3-methylbenzaldehyde + NAD+ + H2O

3-methylbenzoate + NADH

Pseudomonas putida

low activity

389581, 390225, 390259

3-nitrobenzaldehyde + NAD+ + H2O

3-nitrobenzoate + NADH

2 entries

4-carboxybenzaldehyde + NAD+ + H2O

4-carboxybenzoate + NADH

Pseudomonas putida

389581

4-chlorobenzaldehyde + NAD+ + H2O

4-chlorobenzoate + NADH

2 entries

4-fluorobenzaldehyde + NAD+ + H2O

4-fluorobenzoate + NADH + H+

2 entries

4-methoxybenzaldehyde + NAD+ + H2O

4-methoxybenzoate + NADH + H+

Pseudomonas putida

low activity

389581, 390259

4-methylbenzaldehyde + NAD+ + H2O

4-methylbenzoate + NADH

Pseudomonas putida

low activity

389581, 390225, 390259

4-nitrobenzaldehyde + NAD+ + H2O

4-nitrobenzoate + NADH + H+

Pseudomonas putida

low activity

390259

5-chloro-2-hydroxymuconic-6-semialdehyde + NAD+

5-chloro-2-hydroxymuconate + NADH

2 entries

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

7 entries

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

6 entries

butyraldehyde + NAD+ + H2O

butyrate + NADH + H+

2 entries

crotonaldehyde + NAD+ + H2O

crotonate + NADH

2 entries

formaldehyde + NAD+ + H2O

formate + NADH

4 entries

formaldehyde + NAD+ + H2O

formate + NADH + H+

Bordetella sp.

relative activity 16,5%

672682

hexaldehyde + NAD+ + H2O

n-hexanoic acid + NADH

Pseudomonas oleovorans

low activity

390254

n-butanal + NAD+ + H2O

n-butanoate + NADH + H+

3 entries

propanal + NAD+ + H2O

n-propanoate + NADH + H+

2 entries

propionaldehyde + NAD+ + H2O

propionate + NADH + H+

2 entries

pyridine 4-carboxyaldehyde + NAD+ + H2O

pyridine 4-carboxylate + NADH

Pseudomonas putida

389581

additional information

10 entries