1.2.1.32: aminomuconate-semialdehyde dehydrogenase

This is an abbreviated version!
For detailed information about aminomuconate-semialdehyde dehydrogenase, go to the full flat file.

Reaction

Synonyms

2-aminomuconate semialdehyde dehydrogenase, 2-aminomuconate-6-semialdehyde dehydrogenase, 2-aminomuconic 6-semialdehyde dehydrogenase, 2-AMS dehydrogenase, 2-hydroxy-5-methyl-6-oxohexa-2,4-dienoate dehydrogenase, 2-hydroxymuconate semialdehyde dehydrogenase, 2-hydroxymuconic 6-semialdehyde dehydrogenase, 2-hydroxymuconic acid semialdehyde dehydrogenase, 2-hydroxymuconic semialdehyde dehydrogenase, aldehyde dehydrogenase, ALDH12, Aldh8a1, alpha-aminomuconic epsilon-semialdehyde dehydrogenase, alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase, AMDH, aminomuconate semialdehyde dehydrogenase, aminomuconate-semialdehyde dehydrogenase, AMSDH, dehydrogenase, 2-hydroxymuconate semialdehyde, dehydrogenase, aminomuconate semialdehyde, HMSD-2, nbaE

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.32 aminomuconate-semialdehyde dehydrogenase

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Results	in table
1	Activating Compound
339	AA Sequence
1	Application
1	CAS Registry Number
13	Cloned(Commentary)
21	Cofactor
1	Crystallization (Commentary)
7	General Information
22	Inhibitors
2	kcat/KM [mM/s]
2	Ki Value [mM]
38	KM Value [mM]
12	Molecular Weight [Da]
25	Natural Substrates/ Products (Substrates)
152	Organism
9	Pathway
2	PDB ID
6	pH Optimum
2	pH Range
1	pI Value
10	Protein Variants
14	Purification (Commentary)
3	Reaction
7	Reaction Type
42	Reference
4	Source Tissue
11	Specific Activity [micromol/min/mg]
1	Storage Stability
127	Substrates and Products (Substrate)
12	Subunits
34	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
5	Turnover Number [1/s]

KM Value

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KM Value on EC 1.2.1.32 - aminomuconate-semialdehyde dehydrogenase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.00059 - 0.097

2-aminomuconate 6-semialdehyde

2 entries

2

2-Fluorobenzaldehyde

Pseudomonas putida

-

-

390259

0.0093

2-hydroxy-5-methyl-6-oxohexa-2,4-dienoate

Pseudomonas putida

-

synonym 5-methyl-2-hydroxymuconic-6-semialdehyde

390225

0.002

2-hydroxy-5-methyl-muconic-6-semialdehyde

Burkholderia cepacia

Q83XU8

pH 8.5, 25°C

654394

0.011 - 0.026

2-hydroxymuconate-6-semialdehyde

4 entries

0.48

2-nitrobenzaldehyde

Pseudomonas putida

-

-

390259

1.3

3-Chlorobenzaldehyde

Pseudomonas putida

-

-

390225, 390259

0.17

3-Fluorobenzaldehyde

Pseudomonas putida

-

-

390225, 390259

0.94

3-Methoxybenzaldehyde

Pseudomonas putida

-

-

390225, 390259

0.63

3-methylbenzaldehyde

Pseudomonas putida

-

-

390225, 390259

0.81

3-Nitrobenzaldehyde

Pseudomonas putida

-

-

390225, 390259

0.7

4-Chlorobenzaldehyde

Pseudomonas putida

-

-

390259

0.31

4-Fluorobenzaldehyde

Pseudomonas putida

-

-

390259

1.1

4-methoxybenzaldehyde

Pseudomonas putida

-

-

390259

0.53

4-methylbenzaldehyde

Pseudomonas putida

-

-

390225, 390259

0.31

4-nitrobenzaldehyde

Pseudomonas putida

-

-

390259

0.083

5-chloro-2-hydroxymuconic-6-semialdehyde

Burkholderia cepacia

Q83XU8

pH 8.5, 25°C

654394

0.46

benzaldehyde

Pseudomonas putida

-

-

389581, 390225

0.019 - 1.316

NAD+

6 entries

additional information

additional information

Pseudomonas fluorescens

Q83V33

Michaelis-Menten steady-state kinetics and kinetic analysis, overview

743338

-

0.00059

2-aminomuconate 6-semialdehyde

Homo sapiens

Q9H2A2

wild type enzyme, pH and temperature not specified in the publication

763259

0.097

2-aminomuconate 6-semialdehyde

Homo sapiens

Q9H2A2

mutant enzyme R109A, pH and temperature not specified in the publication

763259

0.011

2-hydroxymuconate-6-semialdehyde

Burkholderia cepacia

Q83XU8

pH 8.5, 25°C

654394

0.016

2-hydroxymuconate-6-semialdehyde

Felis catus

-

-

4568, 390244

0.017

2-hydroxymuconate-6-semialdehyde

Pseudomonas putida

-

-

390225

0.026

2-hydroxymuconate-6-semialdehyde

Pseudomonas oleovorans

-

-

390254

0.019

NAD+

Felis catus

-

-

4568, 390244

0.046

NAD+

Burkholderia cepacia

Q83XU8

pH 8.5, 25°C, with 2-hydroxy-5-methyl-muconic-6-semialdehyde as substrate

654394

0.074

NAD+

Pseudomonas oleovorans

-

-

390254

0.294

NAD+

Burkholderia cepacia

Q83XU8

pH 8.5, 25°C, with 2-hydroxymuconate-6-semialdehyde as substrate

654394

0.33

NAD+

Pseudomonas putida

-

-

390225

1.316

NAD+

Burkholderia cepacia

Q83XU8

pH 8.5, 25°C, with 5-chloro-2-hydroxymuconic-6-semialdehyde as substrate

654394