1.2.1.31: L-aminoadipate-semialdehyde dehydrogenase

This is an abbreviated version!
For detailed information about L-aminoadipate-semialdehyde dehydrogenase, go to the full flat file.

Word Map on EC 1.2.1.31

1.2.1.31

epilepsy

seizure

pyridoxine

pyridoxine-dependent

beta-ars

pipecolic

alpha2-ars

antiepileptic

phentolamine

folinic

saccharopine

alpha-adrenoceptor

alpha2-adrenergic

seizure-free

lysine-restricted

rauwolscine

alpha1a-ar

piperideine-6-carboxylate

alpha1a

medicine

Reaction

Synonyms

2-aminoadipate semialdehyde dehydrogenase, 2-aminoadipic 6-semialdehyde dehydrogenase, 2-aminoadipic semialdehyde dehydrogenase, AAR, AASADH, adipic 6-semialdehyde dehydrogenase, aldehyde dehydrogenase 7A1, Aldh7a1, alpha-AAR, alpha-AASA dehydrogenase, alpha-aminoadipate reductase Lys1p, alpha-aminoadipate semialdehyde dehydrogenase, alpha-aminoadipate-semialdehyde dehydrogenase, alpha-aminoadipic acid-delta-semialdehyde dehydrogenase, alpha-aminoadipic semialdehyde dehydrogenase, Alpha-AR, antiquitin, dehydrogenase, aminoadipate semialdehyde, human U26, L-alpha-aminoadipate delta-semialdehyde oxidoreductase, L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase, L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase, L-aminoadipate-semialdehyde dehydrogenase, Lys1p, Nalpha-Z-L-AASA dehydrogenase, U26

ECTree

1 Oxidoreductases

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.1.31 L-aminoadipate-semialdehyde dehydrogenase

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Results	in table
5	Activating Compound
1347	AA Sequence
1	Application
1	CAS Registry Number
14	Cloned(Commentary)
26	Cofactor
542	Disease/ Diagnostics
1	Expression
6	General Information
4	General Stability
41	Inhibitors
7	Ki Value [mM]
22	KM Value [mM]
5	Localization
14	Metals/Ions
12	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
43	Organism
6	Pathway
131	PDB ID
8	pH Optimum
3	pH Range
1	pH Stability
6	Posttranslational Modification
24	Protein Variants
9	Purification (Commentary)
1	Reaction
5	Reaction Type
41	Reference
82	Source Tissue
22	Specific Activity [micromol/min/mg]
3	Storage Stability
57	Substrates and Products (Substrate)
4	Subunits
42	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
8	Temperature Stability [°C]
2	Turnover Number [1/s]

Engineering

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Engineering on EC 1.2.1.31 - L-aminoadipate-semialdehyde dehydrogenase

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Go to Protein Variants Search

G848K

Blastobotrys adeninivorans

enzyme activity not detectable

288187

G874ade/874R/874K

Blastobotrys adeninivorans

lys arg double mutation in strain G874 isolated after a second induced mutagenesis in ade mutant G846

288187

G905K

Blastobotrys adeninivorans

enzyme activity detectable

288187

G982K

Blastobotrys adeninivorans

enzyme activity detectable

288187

G983ade/983K

Blastobotrys adeninivorans

lys mutation in strain G983 isolated after a second induced mutagenesis in ade mutant G846, enzyme activity detectable

288187

G984K

Blastobotrys adeninivorans

very low activity

288187

G985K

Blastobotrys adeninivorans

enzyme activity not detectable

288187

C125I