1.2.1.27: methylmalonate-semialdehyde dehydrogenase (CoA-acylating)
This is an abbreviated version!
For detailed information about methylmalonate-semialdehyde dehydrogenase (CoA-acylating), go to the full flat file.
Word Map on EC 1.2.1.27
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1.2.1.27
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lysosomotropic
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3-hydroxyisobutyrate
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coa-dependent
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mississippi
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propionyl-coa
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aldh6a1
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3-hydroxypropionic
- 1.2.1.27
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lysosomotropic
- 3-hydroxyisobutyrate
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coa-dependent
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mississippi
- propionyl-coa
- aldh6a1
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3-hydroxypropionic
Reaction
Synonyms
Aldh6a1, dddC, FG99_15390, KES23460, malonate-semialdehyde dehydrogenase, methylmalonate semialdehyde dehydrogenase, methylmalonate semialdehyde dehydrogenase protein, methylmalonate-semialdehyde dehydrogenase, methylmalonic acid semialdehyde dehydrogenase, MGG_01606, MMSADH, MMSDH, MoMSDH, MSDH, NAD-dependent malonate-semialdehyde dehydrogenase, OdoMMSDH, OsALDH6, PA3570, SSO1218
ECTree
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Substrates Products
Substrates Products on EC 1.2.1.27 - methylmalonate-semialdehyde dehydrogenase (CoA-acylating)
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REACTION DIAGRAM
methylmalonate-semialdehyde + CoA + NAD+
propionyl-CoA + NADH + H+ + HCO3-
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-
-
-
?
p-nitrophenyl acetate + CoA + NAD+
p-nitrophenol + acetyl-CoA + NADH
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-
-
ir
propionaldehyde + CoA + H2O + NAD+
?
no physiological substrate
-
-
?
propionaldehyde + CoA + NAD+
? + NADH
highest activity, no physiological substrate for MSDH, it only forms the same thiopropionyl enzyme intermediate as methylmalonate semialdehyde and malonate semialdehyde
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-
?
propanoyl-CoA + HCO3- + NADH
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-
-
?
2-methyl-3-oxopropanoate + CoA + H2O + NAD+
propanoyl-CoA + HCO3- + NADH
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-
-
?
2-methyl-3-oxopropanoate + CoA + H2O + NAD+
propanoyl-CoA + HCO3- + NADH
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-
-
?
2-methyl-3-oxopropanoate + CoA + H2O + NAD+
propanoyl-CoA + HCO3- + NADH
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-
-
?
propanoyl-CoA + HCO3- + NADH + H+
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-
-
?
2-methyl-3-oxopropanoate + CoA + H2O + NAD+
propanoyl-CoA + HCO3- + NADH + H+
Pyricularia oryzae ATCC MYA-4617
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-
-
?
2-methyl-3-oxopropanoate + CoA + H2O + NAD+
propanoyl-CoA + HCO3- + NADH + H+
Pyricularia oryzae FGSC 8958
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-
-
?
propanoyl-CoA + CO2 + NADH
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-
-
-
?
2-methyl-3-oxopropanoate + CoA + NAD+
propanoyl-CoA + CO2 + NADH
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-
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?, ir
2-methyl-3-oxopropanoate + CoA + NAD+
propanoyl-CoA + CO2 + NADH
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-
-
-
ir
2-methyl-3-oxopropanoate + CoA + NAD+
propanoyl-CoA + CO2 + NADH
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other acyl acceptor: 2-mercaptoethanol
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ir
2-methyl-3-oxopropanoate + CoA + NAD+
propanoyl-CoA + CO2 + NADH
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other acyl acceptor: 2-mercaptoethanol
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ir
2-methyl-3-oxopropanoate + CoA + NAD+
propanoyl-CoA + CO2 + NADH
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other acyl acceptor: 2-mercaptoethanol
-
ir
2-methyl-3-oxopropanoate + CoA + NAD+
propanoyl-CoA + CO2 + NADH
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-
-
-
ir
2-methyl-3-oxopropanoate + CoA + NAD+
propanoyl-CoA + CO2 + NADH
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other acyl acceptor: 2-mercaptoethanol
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ir
2-methyl-3-oxopropanoate + CoA + NAD+
propanoyl-CoA + CO2 + NADH
-
-
-
-
ir
2-methyl-3-oxopropanoate + CoA + NAD+
propanoyl-CoA + CO2 + NADH
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both stereoisomers are oxidized
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ir
acetyl-CoA + CO2 + NADH
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-
-
?
malonate semialdehyde + CoA + H2O + NAD+
acetyl-CoA + CO2 + NADH
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-
-
?
malonate semialdehyde + CoA + NAD+
acetyl-CoA + CO2 + NADH
-
-
-
?
malonate semialdehyde + CoA + NAD+
acetyl-CoA + CO2 + NADH
-
-
-
?
propanoyl-CoA + HCO3- + NADH
-
-
-
-
?
methylmalonate semialdehyde + CoA + H2O + NAD+
propanoyl-CoA + HCO3- + NADH
weaker stabilization of the adenine ring triggers early NADH release in MSDH-catalyzed reaction
-
-
?
methylmalonate semialdehyde + CoA + H2O + NAD+
propanoyl-CoA + HCO3- + NADH
-
-
-
?
methylmalonate semialdehyde + CoA + H2O + NAD+
propanoyl-CoA + HCO3- + NADH
-
-
-
?
?
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ALDH superfamily represents a group of enzymes that catalyze the oxidation of endogenous and exogenous aldehydes to the corresponding carboxylic acids
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-
?
additional information
?
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the malonate-semialdehyde dehydrogenase is selective towards malonate semialdehyde and generates acetyl-CoA in an NAD-dependent and CoA-dependent reaction, although a slower CoA-independent reaction generating acetate is also observed
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-
?
additional information
?
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the malonate-semialdehyde dehydrogenase is selective towards malonate semialdehyde and generates acetyl-CoA in an NAD-dependent and CoA-dependent reaction, although a slower CoA-independent reaction generating acetate is also observed
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-
?
additional information
?
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no activity is observed for the substrates D,L-glyceraldehyde, D,L-glyceraldehyde 3-phosphate and D,L-glycolaldehyde neither with NAD+ nor with NADP+ as cosubstrate
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-
?
additional information
?
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no activity is observed for the substrates D,L-glyceraldehyde, D,L-glyceraldehyde 3-phosphate and D,L-glycolaldehyde neither with NAD+ nor with NADP+ as cosubstrate
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-
?
additional information
?
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no activity detected in the presence of NADP+ as cosubstrate, no activity with D,L-glyceraldehyde, D,L-glyceraldehyde-3-phosphate and D,L-glycolaldehyde - neither with NAD+ nor with NADP+ as cosubstrate
-
-
?
additional information
?
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no activity detected in the presence of NADP+ as cosubstrate, no activity with D,L-glyceraldehyde, D,L-glyceraldehyde-3-phosphate and D,L-glycolaldehyde - neither with NAD+ nor with NADP+ as cosubstrate
-
-
?
additional information
?
-
no activity is observed for the substrates D,L-glyceraldehyde, D,L-glyceraldehyde 3-phosphate and D,L-glycolaldehyde neither with NAD+ nor with NADP+ as cosubstrate
-
-
?
additional information
?
-
no activity detected in the presence of NADP+ as cosubstrate, no activity with D,L-glyceraldehyde, D,L-glyceraldehyde-3-phosphate and D,L-glycolaldehyde - neither with NAD+ nor with NADP+ as cosubstrate
-
-
?