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1.2.1.25: branched-chain alpha-keto acid dehydrogenase system

This is an abbreviated version!
For detailed information about branched-chain alpha-keto acid dehydrogenase system, go to the full flat file.

Word Map on EC 1.2.1.25

Reaction

3-methyl-2-oxobutanoate
+
CoA
+
NAD+
=
2-methylpropanoyl-CoA
+
CO2
+
NADH
+
H+

Synonyms

2-oxoisovalerate dehydrogenase, alpha-ketoisovalerate dehydrogenase, BCKD, BCKD complex, BCKDalpha, BCKDbeta, BCKDC, BCKDH, BCKDHA, BCKDHB, bkdA, BKDH, branched chain alpha-keto acid dehydrogenase complex, branched chain keto-acid dehydrogenase, branched-chain alpha-keto acid dehydrogenase complex, branched-chain alpha-ketoacid dehydrogenase, branched-chain alpha-ketoacid dehydrogenase complex, branched-chain alpha-ketoacid dehydrogenase complex E1alpha subunit, branched-chain ketoacid dehydrogenase, branched-chain-keto-acid dehydrogenase alpha, branched-chain-keto-acid dehydrogenase beta, dehydrogenase, 2-oxoisovalerate (acylating), E1alpha subunit, E1beta subunit, mitochondrial branched-chain keto-acid dehydrogenase, More

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.25 branched-chain alpha-keto acid dehydrogenase system

Expression

Expression on EC 1.2.1.25 - branched-chain alpha-keto acid dehydrogenase system

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
BCKD and BCKDK mRNA decrease significantly immediately after CCI-induced traumatic brain injury (TBI) in the rat. Brain BCKD mRNA levels decrease significantly in the craniotomy, contralateral CCI-induced TBI, and ipsilateral CCI at 4 and 24 h post-TBI, and the decrease remains significant in the contralateral CCI-induced TBI 3 days post-CCI. Phosphorylated BCKD proteins (pBCKD) increase significantly in the ipsilateral-CCI-induced TBI hemisphere. Glutamate treatment (0.025 mM for 24 h) significantly decreases pBCKD protein in neurons
Lactococci produce acetic and propionic acid during logarithmic growth and starvation
transforming growth factor beta treatment (0.010 mg/ml for 48 h) significantly increases pBCKD protein expression in astrocytes