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1.2.1.23: 2-oxoaldehyde dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about 2-oxoaldehyde dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.2.1.23

Reaction

a 2-oxoaldehyde
+
NAD+
+
H2O
=
a 2-oxo carboxylate
+
NADH
+
H+

Synonyms

2-ketoaldehyde dehydrogenase, ADH1, alpha-ketoaldehyde dehydrogenase, methylglyoxal dehydrogenase, MGD, NAD+-linked alcohol dehydrogenase 1, NAD+-linked methylglyoxal dehydrogenase, NAD-dependent alpha-ketoaldehyde dehydrogenase, NAD-linked alpha-ketoaldehyde dehydrogenase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.23 2-oxoaldehyde dehydrogenase (NAD+)

Reference

Reference on EC 1.2.1.23 - 2-oxoaldehyde dehydrogenase (NAD+)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Oimomi, M.; Hata, F.; Nakamichi, T.; Baba, S.; Kato, H.
Purification of alpha-ketoaldehyde dehydrogenase from the human liver and its possible significance in the control of glycation
Experientia
45
463-466
1989
Homo sapiens
Manually annotated by BRENDA team
Rhee, H.; Watanabe, K.; Murata, K.; Kimura, A.
Metabolism of 2-ketoaldehydes in bacteria: oxidative conversion of methylglyoxal to pyruvate by an enzyme from Pseudomonas putida
Agric. Biol. Chem.
51
1059-1066
1987
Pseudomonas putida
-
Manually annotated by BRENDA team
Saez, G.T.; Blay, P.; Vina, J.R.; Vina, J.
Glucose formation from methylglyoxal in rat hepatocytes
Biochem. Soc. Trans.
13
945-946
1985
Rattus norvegicus
-
Manually annotated by BRENDA team
Ray, S.; Ray, M.
Purification and characterization of NAD and NADP-linked alpha-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate
J. Biol. Chem.
257
10566-10570
1982
Capra hircus
Manually annotated by BRENDA team
Ray, M.; Ray, S.
On the interaction of nucleotides and glycolytic intermediates with NAD-linked alpha-ketoaldehyde dehydrogenase
J. Biol. Chem.
257
10571-10574
1982
Capra hircus
Manually annotated by BRENDA team
Dunkerton, J.; James, S.P.
Some observations on the NADP+-linked oxidation of methylglyoxal catalysed by 2-Oxoaldehyde dehydrogenase
Biochem. J.
153
503-504
1976
Ovis aries
Manually annotated by BRENDA team
Dunkerton, J.; James, S.P.
Purification of 2-oxoaldehyde dehydrogenase and its dependence on unusual amines
Biochem. J.
149
609-617
1975
Ovis aries
Manually annotated by BRENDA team
Willetts, A.J.; Turner, J.M.
Threonine metabolism in a strain of Bacillus subtilis: enzymes acting on methylglyoxal
Biochim. Biophys. Acta
222
668-670
1970
Bacillus subtilis
Manually annotated by BRENDA team
Jellum, E.
Metabolism of the ketoaldehyde 2-keto-3-deoxyglucose
Biochim. Biophys. Acta
165
357-363
1968
Ovis aries, Rattus norvegicus
Manually annotated by BRENDA team
Monder, C.
alpha-Keto aldehyde dehydrogenase, an enzyme that catalyzes the enzymic oxidation of methylglyoxal to pyruvate
J. Biol. Chem.
242
4603-4609
1967
Ovis aries
Manually annotated by BRENDA team
Fujii, E.; Iwase, H.; Ishii-Karakasa, I.; Yajima, Y.; Hotta, K.
The presence of 2-keto-3-deoxygluconic acid and oxoaldehyde dehydrogenase activity in human erythrocytes
Biochem. Biophys. Res. Commun.
210
852-857
1995
Homo sapiens
Manually annotated by BRENDA team
Bender, K.; Seibert, R.T.; Wienker, T.F.; Kren, V.; Pravenec, M.; Bissbort, S.
Biochemical genetics of methylglyoxal dehydrogenases in the laboratory rat (Rattus norvegicus)
Biochem. Genet.
32
147-154
1994
Rattus norvegicus
Manually annotated by BRENDA team
Kwak, M.K.; Ku, M.; Kang, S.O.
NAD+-linked alcohol dehydrogenase 1 regulates methylglyoxal concentration in Candida albicans
FEBS Lett.
588
1144-1153
2014
Candida albicans (A0A1D8PP43), Candida albicans
Manually annotated by BRENDA team