1.2.1.19: aminobutyraldehyde dehydrogenase

This is an abbreviated version!
For detailed information about aminobutyraldehyde dehydrogenase, go to the full flat file.

Reaction

Synonyms

4-aminobutanal dehydrogenase, 4-aminobutyraldehyde dehydrogenase, ABAL dehydrogenase, ABALDH, ALDH10A8, ALDH10A9, AMADH, AMADH1, AMADH2, aminoaldehyde dehydrogenase, BADH, betaine aldehyde dehydrogenase, dehydrogenase, aminobutyraldehyde, EC 1.5.1.35, gadbh, gamma-aminobutanal dehydrogenase, gamma-aminobutyraldehyde dehydroganase, gamma-aminobutyraldehyde dehydrogenase, gamma-guanidinobutyraldehyde dehydrogenase, MdAMADH1, MdAMADH2, More, NAD+-aminoaldehyde dehydrogenase, NAD+-dependent aminoaldehyde dehydrogenase, PatD, PsAMADH 1, PsAMADH 2, SlAMADH1, SlAMADH2, YdcW, ZmAMADH1a, ZmAMADH1b, ZmAMADH2

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.19 aminobutyraldehyde dehydrogenase

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2	Activating Compound
3602	AA Sequence
2	Application
1	CAS Registry Number
17	Cloned(Commentary)
42	Cofactor
4	Crystallization (Commentary)
25	Disease/ Diagnostics
7	Expression
22	General Information
3	General Stability
36	Inhibitors
37	kcat/KM [mM/s]
7	Ki Value [mM]
150	KM Value [mM]
19	Localization
4	Metals/Ions
19	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
63	Organism
12	Pathway
62	PDB ID
26	pH Optimum
10	pH Range
1	pH Stability
2	pI Value
4	Protein Variants
19	Purification (Commentary)
2	Reaction
3	Reaction Type
49	Reference
41	Source Tissue
38	Specific Activity [micromol/min/mg]
5	Storage Stability
199	Substrates and Products (Substrate)
18	Subunits
83	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
1	Temperature Range [°C]
23	Temperature Stability [°C]
69	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.2.1.19 - aminobutyraldehyde dehydrogenase

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SYSTEMATIC NAME

IUBMB Comments

4-aminobutanal:NAD+ 1-oxidoreductase

The enzyme from some species exhibits broad substrate specificity and has a marked preference for straight-chain aldehydes (up to 7 carbon atoms) as substrates [9]. The plant enzyme also acts on 4-guanidinobutanal (cf. EC 1.2.1.54 gamma-guanidinobutyraldehyde dehydrogenase). As 1-pyrroline and 4-aminobutanal are in equilibrium and can be interconverted spontaneously, 1-pyrroline may act as the starting substrate. The enzyme forms part of the arginine-catabolism pathway [8] and belongs in the aldehyde dehydrogenase superfamily [9].