1.2.1.16: succinate-semialdehyde dehydrogenase [NAD(P)+]

This is an abbreviated version!
For detailed information about succinate-semialdehyde dehydrogenase [NAD(P)+], go to the full flat file.

Reaction

Synonyms

3-sulfopropanal dehydrogenase, ALDH, BADH, BsSSADH, cce4228, cce4228 protein, dehydrogenase, succinate semialdehyde (nicotinamide adenine dinucleotide (phosphate)), gabD, GabD dehydrogenase, GabD1, gapN-2, More, NAD(P)+-coupled 3-sulfopropanal dehydrogenase, NAD(P)+-dependent benzaldehyde dehydrogenase, NAD(P)+-dependent succinate semialdehyde dehydrogenase, NAD(P)+-dependent succinic semialdehyde dehydrogenase, NAD(P)-dependent benzaldehyde dehydrogenase, NAD+/NADP+-dependent benzaldehyde dehydrogenase, NAD+/NADP+-dependent SSADH, SpSSADH, SSA dehydrogenase, SSADH, SSADH-II, SSADHase, SSDH, SSO1842, ST0064, succinate semialdehyde dehydrogenase, succinate semialdehyde dehydrogenase (nicotinamide adenine dinucleotide (phosphate)), succinate-semialdehyde dehydrogenase, succinate-semialdehyde dehydrogenase (NAD(P)), succinate-semialdehyde dehydrogenase (NAD(P)+), succinic semialdehyde dehydrogenase, succinic semialdehyde:NAD(P)+ oxidoreductase, sulfopropanal dehydrogenase, YneI

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+]

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
18	Activating Compound
9051	AA Sequence
2	Application
1	CAS Registry Number
17	Cloned(Commentary)
64	Cofactor
4	Crystallization (Commentary)
3	Expression
13	General Information
4	General Stability
31	Inhibitors
80	kcat/KM [mM/s]
9	Ki Value [mM]
123	KM Value [mM]
8	Localization
9	Metals/Ions
21	Molecular Weight [Da]
57	Natural Substrates/ Products (Substrates)
681	Organism
1	Oxidation Stability
9	Pathway
47	PDB ID
16	pH Optimum
8	pH Range
4	pH Stability
48	Protein Variants
21	Purification (Commentary)
4	Reaction
4	Reaction Type
52	Reference
6	Source Tissue
78	Specific Activity [micromol/min/mg]
5	Storage Stability
147	Substrates and Products (Substrate)
18	Subunits
82	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
5	Temperature Stability [°C]
91	Turnover Number [1/s]

pH Range

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

pH Range on EC 1.2.1.16 - succinate-semialdehyde dehydrogenase [NAD(P)+]

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to pH Range Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5 - 10

Pseudomonas putida

-

KM value for NAD+ increases from 0.3 to 1 mM as the pH changes from pH 5 to 10. The pH profile data are obtained at a NAD+ concentration of 5 mM, essentially saturating across the entire pH range. Similarly, data for the NADP+ pH profile are obtained at 10 mM NADP+

685387

5.5 - 10

Mycobacterium tuberculosis

-

the enzyme cannot be assayed below pH 5.5, due to precipitation and loss of activity

724115

7 - 9.3

Pseudomonas fluorescens

-

at pH 7.0 and 9.3: about 30% of activity maximum

288046

7.5 - 9.5

Euglena gracilis

-

-

288042

8 - 10.5

Cupriavidus necator

Q0K2K1

specific activity increases steadily to a broad optimum

698627

8.7 - 10.6

Cereibacter sphaeroides

-

with NAD+, at pH 8.7: 45% of activity maximum, at pH 10.6: about 50% of activity maximum

288044

8.7 - 10.9

Cereibacter sphaeroides

-

with NADP+, at pH 8.7: about 30% of activity maximum, at pH 10.9: about 65% of activity maximum

288044

additional information

Pseudomonas putida

-

The pH profiles are bell-shaped indicating that two ionizable groups are involved in the catalytic mechanism.

685387