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1.18.6.1: nitrogenase

This is an abbreviated version!
For detailed information about nitrogenase, go to the full flat file.

Word Map on EC 1.18.6.1

Reaction

4 reduced ferredoxin + 8 H+ +

N2
+ 16 ATP + 16 H2O = 4 oxidized ferredoxin +
H2
 + 2 NH3 + 16 ADP + 16 phosphate

Synonyms

ARA, dinitrogenase, EC 1.18.2.1, Kp2, Mo nitrogenase, Mo-dependent nitrogenase, Mo-Fe nitrogenase, Mo-nitrogenase, MoFe protein, MoFe-protein, molybdenum nitrogenase, molybdenum-containing nitrogenase, molybdenum-iron protein, molybdenum-nitrogenase, More, N2ase, nif, nif1, nif2, nifD, NifDK, NifH, NifH2, nifHDK, nifK, nifM, nitrogenase Fe protein, nitrogenase Fe-protein, nitrogenase FeVco, nitrogenase iron-protein, nitrogenase MoFe protein, nitrogenase MoFe-protein, nitrogenase molybdenum iron protein, nitrogenase molybdenum-iron protein, V-nitrogenase, vanadium nitrogenase, vanadium-nitrogenase, VnfDGK, VnfH

ECTree

     1 Oxidoreductases
         1.18 Acting on iron-sulfur proteins as donors
             1.18.6 With dinitrogen as acceptor
                1.18.6.1 nitrogenase

Temperature Range

Temperature Range on EC 1.18.6.1 - nitrogenase

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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
15 - 40
-
no maximum with Ti3+ as reductant
additional information
-
using buffer 3-(N-morpholino)propanesulfonic acid, which has a very small temperature coefficient, temperature-dependent elctron transfer rate constants are observed, with nonlinear Arrhenius plots and with electron transfers gated across the temperature range by a conformational change that involves the binding of numerous water molecules, consistent with an unchanging electron transfer mechanism. There is no solvent kinetic isotope effect throughout the temperature range studied, consistent with an unchanging mechanismn. The nonlinear Arrhenius plots are explained by the change in heat capacity caused by the binding of water molecules in an invariant gating electron transfer mechanism. The observations contradict the idea of a change in electron transfer mechanism with cooling