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1.18.1.6: adrenodoxin-NADP+ reductase

This is an abbreviated version!
For detailed information about adrenodoxin-NADP+ reductase, go to the full flat file.

Word Map on EC 1.18.1.6

Reaction

2 reduced adrenodoxin +

NADP+
+
H+
= 2 oxidized adrenodoxin +
NADPH

Synonyms

AdR, adrenodoxin oxidoreductase, adrenodoxin reductase, ADX reductase, AdxR, FDXR, ferredoxin reductase, FLP, FprA, NADPH adrenodoxin reductase, NADPH-adrenodoxin reductase, NADPH-dependent adrenodoxin reductase, NADPH:adrenal ferredoxin adrenodoxin reductase, NADPH:adrenal ferredoxin oxidoreductase, NADPH:adrenodoxin oxidoreductase, NADPH:adrenodoxin oxidoreductase mitochondrial, NADPH:adrenodoxin reductase, nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase, TPNH-cytochrome P-450 reductase

ECTree

     1 Oxidoreductases
         1.18 Acting on iron-sulfur proteins as donors
             1.18.1 With NAD+ or NADP+ as acceptor
                1.18.1.6 adrenodoxin-NADP+ reductase

Disease

Disease on EC 1.18.1.6 - adrenodoxin-NADP+ reductase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Carcinoma
Ferredoxin Reductase Is Useful for Predicting the Effect of Chemoradiation Therapy on Esophageal Squamous Cell Carcinoma.
Colorectal Neoplasms
Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells.
Ferredoxin reductase: pharmacogenomic assessment in colorectal cancer.
Gene expression of ferredoxin reductase predicts outcome in patients with metastatic colorectal cancer treated by 5-fluorouracil plus leucovorin.
Influence of 5-fluorouracil on ferredoxin reductase mRNA splice variants in colorectal carcinomas.
Esophageal Squamous Cell Carcinoma
Ferredoxin Reductase Is Useful for Predicting the Effect of Chemoradiation Therapy on Esophageal Squamous Cell Carcinoma.
Hearing Loss
Report of a case with ferredoxin reductase (FDXR) gene variants in a Chinese boy exhibiting hearing loss, visual impairment, and motor retardation.
Herpes Zoster
Localization of cytochrome P-450-linked mixed function oxidase and steroid hydroxylations within zones of bovine adrenocortices.
Zonal distribution of cytochromes P-450 and related enzymes of bovine adrenal cortex--quantitative assay of concentrations and total contents.
Iron Overload
Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis.
Neoplasms
Apoptotic response to 5-fluorouracil treatment is mediated by reduced polyamines, non-autocrine Fas ligand and induced tumor necrosis factor receptor 2.
Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions.
Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2.
Ferredoxin reductase regulates proliferation, differentiation, cell cycle and lipogenesis but not apoptosis in SZ95 sebocytes.
Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells.
Optic Atrophy
Biallelic mutations in the ferredoxin reductase gene cause novel mitochondriopathy with optic atrophy.
Tuberculosis
MT FdR: a ferredoxin reductase from M. tuberculosis that couples to MT CYP51.
Vision Disorders
Report of a case with ferredoxin reductase (FDXR) gene variants in a Chinese boy exhibiting hearing loss, visual impairment, and motor retardation.