1.18.1.4: rubredoxin-NAD(P)+ reductase

This is an abbreviated version!
For detailed information about rubredoxin-NAD(P)+ reductase, go to the full flat file.

Reaction

2 reduced rubredoxin +

Synonyms

NAD(P)-rubredoxin oxidoreductase, NAD(P)H-dependent rubredoxin reductase, NAD(P)H-rubredoxin oxidoreductase, NADPH:rubredoxin oxidoreductase, NROR, PF1197, reductase, rubredoxin-nicotinamide adenine dinucleotide (phosphate), rubredoxin-nicotinamide adenine dinucleotide (phosphate) reductase, rubredoxin-nicotinamide adenine dinucleotide phosphate reductase

ECTree

     1 Oxidoreductases

         1.18 Acting on iron-sulfur proteins as donors

             1.18.1 With NAD⁺ or NADP⁺ as acceptor

                1.18.1.4 rubredoxin-NAD(P)+ reductase

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Results	in table
1	Activating Compound
1	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
8	Cofactor
1	Expression
1	General Information
1	Inhibitors
13	kcat/KM [mM/s]
17	KM Value [mM]
1	Localization
1	Metals/Ions
6	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
6	Organism
3	Pathway
4	pH Optimum
1	pI Value
4	Purification (Commentary)
1	Reaction
3	Reaction Type
6	Reference
2	Source Tissue
2	Specific Activity [micromol/min/mg]
35	Substrates and Products (Substrate)
8	Subunits
15	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
13	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 1.18.1.4 - rubredoxin-NAD(P)+ reductase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

2 ferricytochrome c + NADH

2 ferrocytochrome c + NAD+ + H+

Pyrococcus furiosus

-

cytochrome c from horse heart

437841

-

-

?

2 oxidized rubredoxin + NADH

2 reduced rubredoxin + NAD+ + H+

Pyrococcus furiosus

-

-

722502

-

-

?

2 oxidized rubredoxin + NADPH

2 reduced rubredoxin + NADP+ + H+

4 entries

2,6-dichloroindophenol + NADH

reduced 2,6-dichloroindophenol + NAD+ + H+

Pyrococcus furiosus

-

-

437841

-

-

?

5,5'-dithiobis(2-nitrobenzoic acid) + NADH

?

Pyrococcus furiosus

-

-

437841

-

-

?

benzyl viologen + NADH

reduced benzyl viologen + NAD+

Pyrococcus furiosus

-

-

437841

-

-

?

FAD + NADH

FADH2 + NAD+

Pyrococcus furiosus

-

-

437841

-

-

?

Fe(III) citrate + NADH

Fe(II) citrate + NAD+

Pyrococcus furiosus

-

-

437841

-

-

?

FMN + NADH

FMNH2 + NAD+

Pyrococcus furiosus

-

-

437841

-

-

?

methyl viologen + NADH

reduced methyl viologen + NAD+ + H+

Pyrococcus furiosus

-

-

437841

-

-

?

oxidized benzyl viologen + NADH

reduced benzyl viologen + NAD+

Pyrococcus furiosus

-

-

722502

-

-

?

oxidized benzyl viologen + NADH

reduced benzyl viologen + NAD+ + H+

Pyrococcus furiosus

Q8U1K9

-

721334

-

-

?

oxidized benzyl viologen + NADPH

reduced benzyl viologen + NADP+

Pyrococcus furiosus

-

-

722502

-

-

?

oxidized benzyl viologen + NADPH

reduced benzyl viologen + NADP+ + H+

Pyrococcus furiosus

Q8U1K9

-

721334

-

-

?

oxidized Clostridium pasteurianum rubredoxin + NADH

reduced Clostridium pasteurianum rubredoxin + NAD+ + H+

2 entries

oxidized Clostridium pasteurianum rubredoxin + NADPH

reduced Clostridium pasteurianum rubredoxin + NADP+ + H+

2 entries

oxidized flavodiiron protein + NADH

reduced flavodiiron protein + NAD+ + H+

2 entries

oxidized flavodiiron protein + NADPH

reduced flavodiiron protein + NADP+ + H+

2 entries

oxidized Pyrococcus furiosus rubredoxin + NADH

reduced Pyrococcus furiosus rubredoxin + NAD+ + H+

Entamoeba histolytica

-

-

744394

-

-

?

oxidized Pyrococcus furiosus rubredoxin + NADPH

reduced Pyrococcus furiosus rubredoxin + NADP+ + H+

Entamoeba histolytica

-

-

744394

-

-

?

oxidized rubredoxin + NADH

reduced rubredoxin + NAD+

Pyrococcus furiosus

-

rubredoxin is the best substrate

437841

-

-

?

oxidized rubredoxin + NADPH

reduced rubredoxin + NADP+

Pyrococcus furiosus

-

-

437841

-

-

?

oxidized rubredoxin + NADPH

reduced rubredoxin + NADP+ + H+

Pyrococcus furiosus

-

-

437841

-

-

r

oxidized rubrerythrin + NADH

reduced rubrerythrin + NAD+ + H+

Entamoeba histolytica

-

-

744394

-

-

?

oxidized rubrerythrin + NADPH

reduced rubrerythrin + NADP+ + H+

Entamoeba histolytica

-

-

744394

-

-

?

additional information

?

-

3 entries

2 oxidized rubredoxin + NADPH

2 reduced rubredoxin + NADP+ + H+

Pyrococcus furiosus

-

-

745202

-

-

?

2 oxidized rubredoxin + NADPH

2 reduced rubredoxin + NADP+ + H+

Pyrococcus furiosus

Q8U1K9

-

721334

-

-

?

2 oxidized rubredoxin + NADPH

2 reduced rubredoxin + NADP+ + H+

Pyrococcus furiosus

-

rubredoxin is the most efficient electron acceptor

722502

-

-

?

2 oxidized rubredoxin + NADPH

2 reduced rubredoxin + NADP+ + H+

Pyrococcus furiosus

Q8U1K9

superoxide reductase mediates reduction of superoxide to hydrogen peroxide in an NADPH-dependent manner via a coupled reaction between NAD(P)H:rubredoxin oxidoreductase, rubredoxin, and superoxide reductase

721334

-

-

?

oxidized Clostridium pasteurianum rubredoxin + NADH

reduced Clostridium pasteurianum rubredoxin + NAD+ + H+

Entamoeba histolytica

-

-

744394

-

-

?

oxidized Clostridium pasteurianum rubredoxin + NADH

reduced Clostridium pasteurianum rubredoxin + NAD+ + H+

Entamoeba histolytica HM1-IMSS

-

-

744394

-

-

?

oxidized Clostridium pasteurianum rubredoxin + NADPH

reduced Clostridium pasteurianum rubredoxin + NADP+ + H+

Entamoeba histolytica

-

-

744394

-

-

?

oxidized Clostridium pasteurianum rubredoxin + NADPH

reduced Clostridium pasteurianum rubredoxin + NADP+ + H+

Entamoeba histolytica HM1-IMSS

-

-

744394

-

-

?

oxidized flavodiiron protein + NADH

reduced flavodiiron protein + NAD+ + H+

Entamoeba histolytica

-

-

744394

-

-

?

oxidized flavodiiron protein + NADH

reduced flavodiiron protein + NAD+ + H+

Entamoeba histolytica HM1-IMSS

-

-

744394

-

-

?

oxidized flavodiiron protein + NADPH

reduced flavodiiron protein + NADP+ + H+

Entamoeba histolytica

-

-

744394

-

-

?

oxidized flavodiiron protein + NADPH

reduced flavodiiron protein + NADP+ + H+

Entamoeba histolytica HM1-IMSS

-

-

744394

-

-

?

additional information

?

-

Entamoeba histolytica

-

the enzyme has no activity with ferredoxins, flavodoxins, and thioredoxins

744394

-

-

?

additional information

?

-

Entamoeba histolytica HM1-IMSS

-

the enzyme has no activity with ferredoxins, flavodoxins, and thioredoxins

744394

-

-

?

additional information

?

-

Pyrococcus furiosus

-

the enzyme does not reduce Pyrococcus furiosus ferredoxin

722502

-

-

?