1.18.1.2: ferredoxin-NADP+ reductase
This is an abbreviated version!
For detailed information about ferredoxin-NADP+ reductase, go to the full flat file.
Word Map on EC 1.18.1.2
-
1.18.1.2
-
nitrate
-
ferredoxins
-
denitrification
-
denitrify
-
reductases
-
heme
-
fad
-
spinach
-
chloroplast
-
copper
-
ammonia
-
nitrous
-
flavin
-
dissimilatory
-
photosystems
-
flavodoxins
-
denitrificans
-
alcaligenes
-
paracoccus
-
n2o
-
anabaena
-
copper-containing
-
thylakoids
-
anammox
-
p450scc
-
semiquinone
-
diaphorase
-
viologen
-
azurins
-
ferredoxin-dependent
-
stutzeri
-
plant-type
-
achromobacter
-
flavoenzymes
-
electron-transfer
-
ammonia-oxidizing
-
plastocyanin
-
dinitrogen
-
photoreduction
-
gogat
-
pregnenolone
-
nitrate-induced
-
xylosoxidans
-
photoreduced
-
wolinella
-
isoalloxazine
-
nitrate-reducing
-
biotechnology
-
nitrosomonas
-
deoxyhemoglobin
-
agriculture
-
single-electron
- 1.18.1.2
- nitrate
- ferredoxins
-
denitrification
-
denitrify
- reductases
- heme
- fad
- spinach
- chloroplast
- copper
- ammonia
-
nitrous
- flavin
-
dissimilatory
- photosystems
- flavodoxins
- denitrificans
- alcaligenes
- paracoccus
- n2o
- anabaena
-
copper-containing
- thylakoids
-
anammox
- p450scc
- semiquinone
- diaphorase
- viologen
- azurins
-
ferredoxin-dependent
- stutzeri
-
plant-type
- achromobacter
-
flavoenzymes
-
electron-transfer
-
ammonia-oxidizing
- plastocyanin
-
dinitrogen
-
photoreduction
- gogat
- pregnenolone
-
nitrate-induced
- xylosoxidans
-
photoreduced
-
wolinella
- isoalloxazine
-
nitrate-reducing
- biotechnology
- nitrosomonas
-
deoxyhemoglobin
- agriculture
-
single-electron
Reaction
2 reduced ferredoxin
+
Synonyms
ABO_0145, adrenodoxin reductase, AnFNR, BsFNR, CT1512, cytochrome b6f -associated ferredoxin:NADP+ oxidoreductase, DA1, EC 1.6.7.1, EC 1.6.99.4, Fd-NADP+ reductase, ferredoxin (flavodoxin)-(reduced) nicotinamide adenine dinucleotide phosphate reductase, ferredoxin (flavodoxin)-NAD(P)H reductase, ferredoxin (flavodoxin)-NADP(H) reductase, ferredoxin (flavodoxin):NADP+ oxidoreductase, ferredoxin NADP oxidoreductase, ferredoxin NADP reductase, ferredoxin NADP(H) oxidoreductase, ferredoxin NADP+ oxidoreductase, ferredoxin NADP+ reductase, ferredoxin nicotinamide adenine dinucleotide phosphate reductase, ferredoxin-NAD(P)+ oxidoreductase, ferredoxin-NAD(P)+ reductase, ferredoxin-NAD(P)H reductase, ferredoxin-NADP oxidoreductase, ferredoxin-NADP reductase, Ferredoxin-NADP(+) reductase, ferredoxin-NADP(H) oxidoreductase, ferredoxin-NADP(H) reductase, ferredoxin-NADP+ oxidoreductase, ferredoxin-NADP+ reductase, ferredoxin-NADP+-oxidoreductase, ferredoxin-NADP+-reductase, ferredoxin-NADP-oxidoreductase, ferredoxin-NADP-reductase, ferredoxin-nicotinamide adenine dinucleotide phosphate reductase, ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase, ferredoxin-TPN reductase, ferredoxin: NADP(+) oxidoreductase, ferredoxin: NADP+ oxidoreductase, ferredoxin:NADP oxidoreductase, ferredoxin:NADP(+) oxidoreductase, ferredoxin:NADP(H) oxidoreductase, ferredoxin:NADP(H) oxidoreductase 2, ferredoxin:NADP+ oxidoreductase, ferredoxin:NADP+ reductase, ferredoxin:NADPH oxidoreductase, ferric reductase, Flavodoxin reductase, FLDR, FLXR, FNR, FNR-A, FNR-B, FNR1, FNR2, FNRII, FNRL, FNRS, FPR, FprA, FprB, Fprs, LFNR1, LFNR2, mitochondrial-type ferredoxin:NADP+ reductase, More, mtFNR, NADH-dependent reduced ferredoxin:NADP oxidoreductase, NADP:ferredoxin oxidoreductase, NADPH ferredoxin reductase, NADPH-dependent ferredoxin reductase, NADPH:ferredoxin oxidoreductase, NfnAB, NfnIII, NFR, PETH, PfFNR, pFNR, photosynthetic ferredoxin NADP+ oxidoreductase, photosynthetic FNR, plastidic-type ferredoxin-NADP+ reductase, PP4_41290, RcFPR, reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase, reductase, ferredoxin-nicotinamide adenine dinucleotide phosphate, RFNR2, ST2133, TgFNR, TPNH-ferredoxin reductase, YumC
ECTree
1.18.1.2 ferredoxin-NADP+ reductaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.18.1.2 - ferredoxin-NADP+ reductase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 oxidized ferredoxin + NADPH
2 reduced ferredoxin + NADP+ + H+
-
-
-
r
2 oxidized ferredoxin + NADPH
2 reduced ferredoxin + NADP+ + H+
-
-
-
r
2 oxidized ferredoxin + NADPH
2 reduced ferredoxin + NADP+ + H+
-
-
-
r
2 oxidized ferredoxin + NADPH
2 reduced ferredoxin + NADP+ + H+
-
-
-
-
r
2 reduced ferredoxin + NADP+
2 oxidized ferredoxin + NADPH + H+
-
-
-
-
r
2 reduced ferredoxin + NADP+
2 oxidized ferredoxin + NADPH + H+
-
-
-
r
2 reduced ferredoxin + NADP+
2 oxidized ferredoxin + NADPH + H+
-
-
-
r
2 reduced ferredoxin + NADP+
2 oxidized ferredoxin + NADPH + H+
-
-
-
-
r
2 reduced ferredoxin + NADP+
2 oxidized ferredoxin + NADPH + H+
-
-
-
-
r
2 reduced ferredoxin + NADP+
2 oxidized ferredoxin + NADPH + H+
-
-
-
-
r
2 reduced ferredoxin + NADP+
2 oxidized ferredoxin + NADPH + H+
the enzyme plays an important role in the redox cycle of ferredoxin in the archaeon
-
-
r
2 reduced ferredoxin + NADP+
2 oxidized ferredoxin + NADPH + H+
the enzyme plays an important role in the redox cycle of ferredoxin in the archaeon
-
-
r
2 reduced ferredoxin + NADP+
2 oxidized ferredoxin + NADPH + H+
-
-
-
r
2 reduced ferredoxin + NADP+
2 oxidized ferredoxin + NADPH + H+
-
-
-
r
2 reduced ferredoxin + NADP+
2 oxidized ferredoxin + NADPH + H+
-
-
-
r
2 reduced ferredoxin + NADP+
2 oxidized ferredoxin + NADPH + H+
ferredoxin Xac1762 is a potential substrate
-
-
?
2 reduced ferredoxin + NADP+
2 oxidized ferredoxin + NADPH + H+
-
-
-
-
r
NADPH + oxidized ferredoxin
NADP+ + reduced ferredoxin
-
first enzyme in mitochondrial P-450-linked monooxygenase system catalyzing several steps in the biosynthesis of steroid hormones, bile acids or vitamin D3 in various tissues
-
-
?
NADPH + oxidized ferredoxin
NADP+ + reduced ferredoxin
-
key enzyme catalyzing the electron transport between NADPH generated by pentose phosphate pathway and ferredoxin in plastids of plant heterotrophic tissues
-
-
?
NADPH + oxidized ferredoxin
NADP+ + reduced ferredoxin
-
supports in vivo reduction of membrane bound adrenal mitochondrial P-450
-
-
?
oxidized ferredoxin + NADPH
reduced ferredoxin + NADP+
-
ferredoxin-dependent enzyme radical generation and enzyme activation, electron supply from NADPH
-
-
?
oxidized ferredoxin + NADPH
reduced ferredoxin + NADP+
-
Hydrogenobacter thermophilus expresses three ferredoxins: [4Fe-4S]-type Fd1 and Fd2, and [2Fe-2S]-type Fd3
-
-
r
oxidized ferredoxin + NADPH
reduced ferredoxin + NADP+
Hydrogenobacter thermophilus TK-6 / IAM 12695
-
Hydrogenobacter thermophilus expresses three ferredoxins: [4Fe-4S]-type Fd1 and Fd2, and [2Fe-2S]-type Fd3
-
-
r
oxidized ferredoxin + NADPH
reduced ferredoxin + NADP+ + H+
-
-
-
r
oxidized ferredoxin + NADPH
reduced ferredoxin + NADP+ + H+
Chlorobaculum tepidum ATCC 49652
-
-
-
r
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
delivers NADPH or reduced ferredoxin for several metabolic reactions, involved in photosynthesis
-
-
r
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
-
-
-
r
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
reverse reaction is involved in activation of enzymes that participate in anaerobic metabolism, removal of free radicals gegnerated during the metabolsim
-
-
r
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
enzyme catalyzes the final step of photosynthetic electron transfer from the iron-sulfur protein ferredoxin reduced by photosystem I to NADP+ providing NADPH necessary for CO2 assimilation in plants, in root and heterotrophic tissue, the reaction is driven towards ferredoxin reduction
-
-
r
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
responsible for NADPH generation
-
-
r
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
enzyme catalyzes the final step of photosynthetic electron transfer fron the iron-sulfur protein ferredoxin reduced by photosystem I to NADP+ providing NADPH necessary for CO2 assimilation, enzyme is involved in dinitrogen fixation in heterocysts
-
-
r
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
enzyme is involved in protection against oxidative stress, and in activation of anaerobic enzymes
-
-
r
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
reverse reaction is involved in activation of enzymes that participate in anaerobic metabolism
-
-
r
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
enzyme catalyzes the final step of photosynthetic electron transfer from the iron-sulfur protein ferredoxin reduced by photosystem I to NADP+ providing NADPH necessary for CO2 assimilation in plants, in root and heterotrophic tissue, the reaction is driven towards ferredoxin reduction
-
-
r
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
responsible for NADPH generation
-
-
r
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
-
-
-
r
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
-
-
?
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
delivers NADPH or reduced ferredoxin for several metabolic reactions, involved in photosynthesis, enzyme-substrate interactions, overview
-
-
r
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
enzyme catalyzes the final step of photosynthetic electron transfer from the iron-sulfur protein ferredoxin reduced by photosystem I to NADP+ providing NADPH necessary for CO2 assimilation in plants, in root and heterotrophic tissue, the reaction is driven towards ferredoxin reduction
-
-
r
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
responsible for NADPH generation
-
-
r
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
terminal step in the non-cyclic photosynthetic electron transfer chain
-
-
?
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
generation of NADPH
-
-
?
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
enzyme is involved in the electron transfer cascade from photosystem I to NADP+, formation of a ternary complex between photosystem I, ferredoxin, and enzyme
-
-
r
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
responsible for NADPH generation
-
-
r
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
enzyme catalyzes the final step of photosynthetic electron transfer from the iron-sulfur protein ferredoxin reduced by photosystem I to NADP+ providing NADPH necessary for CO2 assimilation in plants, in root and heterotrophic tissue, the reaction is driven towards ferredoxin reduction
-
-
r
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
in root and heterotrophic tissue, the reaction is driven towards ferredoxin reduction, reaction is part of nitrogen assimilation in nonphotosynthetic tissues
-
-
r
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
responsible for NADPH generation
-
-
r
reduced ferredoxin + NADP+ + H+
oxidized ferredoxin + NADPH
-
-
-
-
?
reduced ferredoxin + NADP+ + H+
oxidized ferredoxin + NADPH
-
-
-
-
?
reduced ferredoxin + NADP+ + H+
oxidized ferredoxin + NADPH
-
-
-
-
?
reduced ferredoxin + NADP+ + H+
oxidized ferredoxin + NADPH
-
-
-
r
reduced ferredoxin + NADP+ + H+
oxidized ferredoxin + NADPH
Chlorobaculum tepidum ATCC 49652
-
-
-
r
reduced ferredoxin + NADP+ + H+
oxidized ferredoxin + NADPH
-
-
-
?
reduced ferredoxin + NADP+ + H+
oxidized ferredoxin + NADPH
-
-
-
?
reduced ferredoxin + NADP+ + H+
oxidized ferredoxin + NADPH
-
-
-
?
reduced ferredoxin + NADP+ + H+
oxidized ferredoxin + NADPH
-
-
-
-
?
reduced ferredoxin + NADP+ + H+
oxidized ferredoxin + NADPH
-
-
-
?
reduced ferredoxin + NADP+ + H+
oxidized ferredoxin + NADPH
-
-
-
?
reduced ferredoxin + NADP+ + H+
oxidized ferredoxin + NADPH
-
-
-
-
r
[4Fe-4S]-ferredoxin + NADPH
reduced [4Fe-4S]-ferredoxin + NADP+
-
[4Fe-4S]-ferredoxin of Pseudomonas putida is similar to ferredoxin FdI of Azotobacter vinelandii, the Pseudomonas putida chromosome contains two [2Fe-2S] ferredoxins (FdA and FdB), three [4Fe-4S] ferredoxins (4FdA, 4FdB and FdxA) and one flavodoxin (Fld)
-
-
r
[4Fe-4S]-ferredoxin + NADPH
reduced [4Fe-4S]-ferredoxin + NADP+
-
[4Fe-4S]-ferredoxin of Pseudomonas putida is similar to ferredoxin FdI of Azotobacter vinelandii, the Pseudomonas putida chromosome contains two [2Fe-2S] ferredoxins (FdA and FdB), three [4Fe-4S] ferredoxins (4FdA, 4FdB and FdxA) and one flavodoxin (Fld)
-
-
r
additional information
?
-
-
phylogenetic evolution, relationships, and classification, overview
-
-
?
additional information
?
-
-
phylogenetic evolution, relationships, and classification, overview
-
-
?
additional information
?
-
-
FNR interacts with several partners, e.g. the NDH complex in the thylakoids, association of FNR with cytochrome b6f or PGRL1 or the photosystem I, overview
-
-
?
additional information
?
-
FNR is bound to the oxygen evolving complex proteins, and also to a heat stable socalled connectein protein of 10 kDa, which binds two molecules of FNR and is involved in membrane binding. Chloroplast FNR co-purifies with the Cyt b6f complex, while unlike bacterial FNR, it does not bind to NDH complexes
-
-
?
additional information
?
-
FNR is bound to the oxygen evolving complex proteins, and also to a heat stable socalled connectein protein of 10 kDa, which binds two molecules of FNR and is involved in membrane binding. Chloroplast FNR co-purifies with the Cyt b6f complex, while unlike bacterial FNR, it does not bind to NDH complexes
-
-
?
additional information
?
-
-
enzyme is involved in nitrogenase reduction, phylogenetic evolution, relationships, and classification, overview
-
-
?
additional information
?
-
-
phylogenetic evolution, relatiionships, and classification, overview
-
-
?
additional information
?
-
-
phylogenetic evolution, relationships, and classification, overview
-
-
?
additional information
?
-
-
enzyme is involved in anaerobic metabolism, phylogenetic evolution, relationships, and classification, overview
-
-
?
additional information
?
-
-
the enzyme reduces flavodoxin I and flavodoxin II, reaction of EC 1.19.1.1, and ferredoxin, ferredoxin being the kinetically and thermodynamically preferred partner. Ferredoxin binds to FNR with high affinity (Kd below 0.5 microM) and is reduced under single-turnover conditions. Flavodoxin I and flavodoxin II show affinities about 4- to 7fold weaker and reduction rates that are 10- to 100fold slower than those for ferredoxin
-
-
?
additional information
?
-
the enzyme reduces flavodoxin I and flavodoxin II, reaction of EC 1.19.1.1, and ferredoxin, ferredoxin being the kinetically and thermodynamically preferred partner. Ferredoxin binds to FNR with high affinity (Kd below 0.5 microM) and is reduced under single-turnover conditions. Flavodoxin I and flavodoxin II show affinities about 4- to 7fold weaker and reduction rates that are 10- to 100fold slower than those for ferredoxin
-
-
?
additional information
?
-
-
phylogenetic evolution, relatiionships, and classification, overview
-
-
?
additional information
?
-
-
heme-iron scavenging by heme oxygenase in Leptospira. interrogans requires only plastidic-type ferredoxin-NADP+ reductase as redox partner. The enzyme provides the electrons for heme turnover by heme oxygenase
-
-
?
additional information
?
-
-
FNR interacts with several partners, e.g. the NDH complex in the thylakoids, association of FNR with cytochrome b6f or PGRL1 or the photosystem I, overview
-
-
?
additional information
?
-
-
enzyme is involved in the antioxidant response and facilitation of the provision of reduced flavodoxin for the reduction of nitrogenase
-
-
?
additional information
?
-
-
phylogenetic evolution, relatiionships, and classification, overview
-
-
?
additional information
?
-
-
pathway of cyclic electron transport includes both ferredoxin and ferredoxin-NADP+ reductase, but not the NADP+-binding site of the reductase
-
-
?
additional information
?
-
-
ferredoxin-NADP+ reductase not involved in cyclic electron transport
-
-
?
additional information
?
-
-
enzyme is involved in cyclic electron transport and chlororespiration
-
-
?
additional information
?
-
-
enzyme is involved in photosynthesis and nitrite assimilation, phylogenetic evolution, relatiionships, and classification, overview
-
-
?
additional information
?
-
-
FNR interacts with several partners, e.g. the NDH complex in the thylakoids, association of FNR with cytochrome b6f or PGRL1 or the photosystem I, overview
-
-
?
additional information
?
-
FNR is bound to the oxygen evolving complex proteins, and also to a heat stable socalled connectein protein of 10 kDa, which binds two molecules of FNR and is involved in membrane binding. Chloroplast FNR co-purifies with the Cyt b6f complex, while unlike bacterial FNR, it does not bind to NDH complexes
-
-
?
additional information
?
-
FNR is bound to the oxygen evolving complex proteins, and also to a heat stable socalled connectein protein of 10 kDa, which binds two molecules of FNR and is involved in membrane binding. Chloroplast FNR co-purifies with the Cyt b6f complex, while unlike bacterial FNR, it does not bind to NDH complexes
-
-
?
additional information
?
-
-
FNR interacts with several partners, e.g. the NDH complex in the thylakoids, association of FNR with cytochrome b6f or PGRL1 or the photosystem I, overview
-
-
?
additional information
?
-
FNR is bound to the oxygen evolving complex proteins, and also to a heat stable socalled connectein protein of 10 kDa, which binds two molecules of FNR and is involved in membrane binding. Chloroplast FNR co-purifies with the Cyt b6f complex, while unlike bacterial FNR, it does not bind to NDH complexes
-
-
?
