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1.17.99.6: epoxyqueuosine reductase

This is an abbreviated version!
For detailed information about epoxyqueuosine reductase, go to the full flat file.

Word Map on EC 1.17.99.6

Reaction

queuosine34 in tRNA
+
acceptor
+
H2O
=
epoxyqueuosine34 in tRNA
+
reduced acceptor

Synonyms

duf 208, oQ reductase, QueG, queH

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.99 With unknown physiological acceptors
                1.17.99.6 epoxyqueuosine reductase

Systematic Name

Systematic Name on EC 1.17.99.6 - epoxyqueuosine reductase

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SYSTEMATIC NAME
IUBMB Comments
queuosine34 in tRNA:acceptor oxidoreductase
This enzyme catalyses the last step in the bacterial biosynthetic pathway to queuosine, the modified guanosine base in the wobble position in tRNAs specific for Tyr, His, Asp or Asn. Two types of enzymes are known to catalyse this activity. QueG enzymes are cobalamin-dependent, while QueH enzymes contain a [4Fe-4S] metallocluster along with an adjacent coordinated iron metal.