1.17.5.1: phenylacetyl-CoA dehydrogenase

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For detailed information about phenylacetyl-CoA dehydrogenase, go to the full flat file.

Reaction

Synonyms

More, oxidase, phenylacetyl coenzyme A (alpha-oxidizing), phenylacetyl-CoA alpha-carbon-oxidizing oxidase, phenylacetyl-CoA-acceptor oxidoreductase, phenylacetyl-CoA:acceptor oxidoreductase

ECTree

     1 Oxidoreductases

         1.17 Acting on CH or CH₂ groups

             1.17.5 With a quinone or similar compound as acceptor

                1.17.5.1 phenylacetyl-CoA dehydrogenase

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1	Activating Compound
3	AA Sequence
2	CAS Registry Number
5	Cofactor
3	Inhibitors
2	KM Value [mM]
2	Localization
4	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
4	Organism
2	Oxidation Stability
3	Pathway
2	pH Optimum
1	pH Range
1	Purification (Commentary)
2	Reaction
4	Reaction Type
2	Reference
2	Specific Activity [micromol/min/mg]
1	Storage Stability
11	Substrates and Products (Substrate)
1	Subunits
6	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.17.5.1 - phenylacetyl-CoA dehydrogenase

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SYSTEMATIC NAME

IUBMB Comments

phenylacetyl-CoA:quinone oxidoreductase

The enzyme from Thauera aromatica is a membrane-bound molybdenum---iron---sulfur protein. The enzyme is specific for phenylacetyl-CoA as substrate. Phenylacetate, acetyl-CoA, benzoyl-CoA, propanoyl-CoA, crotonyl-CoA, succinyl-CoA and 3-hydroxybenzoyl-CoA cannot act as substrates. The oxygen atom introduced into the product, phenylglyoxylyl-CoA, is derived from water and not molecular oxygen. Duroquinone, menaquinone and 2,6-dichlorophenolindophenol (DCPIP) can act as acceptor, but the likely physiological acceptor is ubiquinone [1]. A second enzyme, EC 3.1.2.25, phenylacetyl-CoA hydrolase, converts the phenylglyoxylyl-CoA formed into phenylglyoxylate.