1.17.5.1: phenylacetyl-CoA dehydrogenase
This is an abbreviated version!
For detailed information about phenylacetyl-CoA dehydrogenase, go to the full flat file.
Reaction
Synonyms
More, oxidase, phenylacetyl coenzyme A (alpha-oxidizing), phenylacetyl-CoA alpha-carbon-oxidizing oxidase, phenylacetyl-CoA-acceptor oxidoreductase, phenylacetyl-CoA:acceptor oxidoreductase
ECTree
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Systematic Name
Systematic Name on EC 1.17.5.1 - phenylacetyl-CoA dehydrogenase
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phenylacetyl-CoA:quinone oxidoreductase
The enzyme from Thauera aromatica is a membrane-bound molybdenum---iron---sulfur protein. The enzyme is specific for phenylacetyl-CoA as substrate. Phenylacetate, acetyl-CoA, benzoyl-CoA, propanoyl-CoA, crotonyl-CoA, succinyl-CoA and 3-hydroxybenzoyl-CoA cannot act as substrates. The oxygen atom introduced into the product, phenylglyoxylyl-CoA, is derived from water and not molecular oxygen. Duroquinone, menaquinone and 2,6-dichlorophenolindophenol (DCPIP) can act as acceptor, but the likely physiological acceptor is ubiquinone [1]. A second enzyme, EC 3.1.2.25, phenylacetyl-CoA hydrolase, converts the phenylglyoxylyl-CoA formed into phenylglyoxylate.