1.17.5.1: phenylacetyl-CoA dehydrogenase
This is an abbreviated version!
For detailed information about phenylacetyl-CoA dehydrogenase, go to the full flat file.
Reaction
Synonyms
More, oxidase, phenylacetyl coenzyme A (alpha-oxidizing), phenylacetyl-CoA alpha-carbon-oxidizing oxidase, phenylacetyl-CoA-acceptor oxidoreductase, phenylacetyl-CoA:acceptor oxidoreductase
ECTree
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Substrates Products
Substrates Products on EC 1.17.5.1 - phenylacetyl-CoA dehydrogenase
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REACTION DIAGRAM
phenylacetyl-CoA + H2O + 2,6-dichlorophenolindophenol
phenylglyoxylyl-CoA + reduced 2,6-dichlorophenolindophenol
phenylacetyl-CoA + H2O + duroquinone
phenylglyoxylyl-CoA + duroquinol
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at 0.3 mM duroquinone, 150% of the activity with 0.25 mM 2,6-dichlorophenolindophenol
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phenylacetyl-CoA + H2O + menadione
phenylglyoxylyl-CoA + menadiol
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at 0.3 mM menadione, 60% of the activity with 0.25 mM 2,6-dichlorophenolindophenol
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?
phenylacetyl-CoA + H2O + ubiquinone
phenylglyoxylyl-CoA + ubiquinol
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ubiquinone is most likely the natural electron acceptor, involved in anaerobic metabolism of phenylalanine, catalyzes the first step in the conversion of phenylacetyl-CoA to phenylglyoxylate, the second step being carried out by EC 3.1.2.25
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phenylglyoxylyl-CoA + reduced 2,6-dichlorophenolindophenol
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four-electron oxidation, uses dichlorophenolindophenol as artificial electron acceptor, 2 mol dichlorophenolindophenol is reduced per mol phenylacetyl-CoA, catalyzes the anaerobic oxidation of the methylene group in the alpha-position to the CoA-activated carboxyl group, molecular oxygen is not required for the oxidation
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phenylacetyl-CoA + H2O + 2,6-dichlorophenolindophenol
phenylglyoxylyl-CoA + reduced 2,6-dichlorophenolindophenol
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uses 2,6-dichlorophenolindophenol as artificial electron acceptor
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phenylglyoxylyl-CoA + quinol
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phenylacetyl-CoA + H2O + quinone
phenylglyoxylyl-CoA + quinol
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four-electron oxidation, catalyzes an alpha-oxidation without utilizing molecular oxygen, ubiquinone is most likely the natural electron acceptor, specific for phenylacetyl-CoA, enzyme preparation catalyzes the reaction phenylacetyl-CoA + 2 H2O + 2 quinone = phenylglyoxylate + 2 quinone H2 + CoASH with phenylglyoxylyl-CoA as free intermediate, which is subsequently hydrolyzed
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no substrate: phenylacetate, inactive electron acceptors: NAD+, NADP+, FAD, FMN, triphenyltetrazoliumchloride
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additional information
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no substrates: phenylacetate, acetyl-CoA, benzoyl-CoA, propionyl-CoA, crotonyl-CoA, succinyl-CoA, 3-hydroxybenzoyl-CoA
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additional information
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anaerobic metabolism of phenylacetate, catalyzes the first step in the conversion of phenylacetyl-CoA to phenylglyoxylate, the second step being carried out by EC 3.1.2.25, cytochrome c probably does not act as physiological electron acceptor
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