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1.17.4.4: vitamin-K-epoxide reductase (warfarin-sensitive)

This is an abbreviated version!
For detailed information about vitamin-K-epoxide reductase (warfarin-sensitive), go to the full flat file.

Word Map on EC 1.17.4.4

Reaction

phylloquinol
+
a protein with a disulfide bond
=
phylloquinone
 +
a protein with reduced L-cysteine residues

Synonyms

EC 1.1.4.1, phylloquinone epoxide reductase, reductase, phylloquinone epoxide, vitamin K 2,3-epoxide reductase, vitamin K 2,3-epoxide reductase complex subunit 1, vitamin K 2,3-epoxide reductase complex subunit-1, vitamin K epoxid reductase, vitamin K epoxide reductase, vitamin K epoxide reductase complex subunit 1, vitamin K oxidoreductase, Vitamin K reductase, vitamin K-2,3-epoxide reductase, vitamin K-2,3-epoxide reductase subunit 1, vitamin K-epoxide reductase, vitamin K1 epoxide reductase, vitaminK epoxide reductase, VKOR, VKOR complex, VKORC1, VKORC1 variant 2, VKORC1-like 1, VKORC1L1, VKORC1v2, warfarin sensitive vitamin K 2,3-epoxide reductase, warfarin-sensitive vitamin K1 2,3-epoxide reductase

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.4 With a disulfide as acceptor
                1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive)

Specific Activity

Specific Activity on EC 1.17.4.4 - vitamin-K-epoxide reductase (warfarin-sensitive)

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000007
-
substrate vitamin K 2,3-epoxide, in the presence of 0.0017 mM R,S-warfarin
0.000009
-
thioredoxin of bovine thymus
0.0000097
-
thioredoxin from bovine thymus as cofactor, enzyme activity in salt washed detergent-solubilized microsomes
0.0000136
-
thioredoxin from Escherichia coli as cofactor, enzyme activity in salt washed detergent-solubilized microsomes
0.000017
-
substrate vitamin K 2,3-epoxide
0.0000256
-
cofactor DTT, enzyme activity in salt washed detergent-solubilized microsomes
0.0000498
-
thioredoxin and protein disulfide-isomerase from bovine thymus as cofactors, enzyme activity in salt washed detergent-solubilized microsomes
0.000057
-
thioredoxin and protein disulfide-isomerase from Escherichia coli as cofactors, enzyme activity in salt washed detergent-solubilized microsomes
0.00008
-
substrate dithiothreitol
0.000137
-
-
0.00061
-
normal and warfarin-resistant rats
0.00099
-
substrate dithiothreitol, in the presence of 0.0017 mM R,S-warfarin
0.108
-
substrate styrene 1',2'-oxide
0.718
-
substrate allylbenzene 2',3'-oxide