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1.17.4.4: vitamin-K-epoxide reductase (warfarin-sensitive)

This is an abbreviated version!
For detailed information about vitamin-K-epoxide reductase (warfarin-sensitive), go to the full flat file.

Word Map on EC 1.17.4.4

Reaction

phylloquinol
+
a protein with a disulfide bond
=
phylloquinone
 +
a protein with reduced L-cysteine residues

Synonyms

EC 1.1.4.1, phylloquinone epoxide reductase, reductase, phylloquinone epoxide, vitamin K 2,3-epoxide reductase, vitamin K 2,3-epoxide reductase complex subunit 1, vitamin K 2,3-epoxide reductase complex subunit-1, vitamin K epoxid reductase, vitamin K epoxide reductase, vitamin K epoxide reductase complex subunit 1, vitamin K oxidoreductase, Vitamin K reductase, vitamin K-2,3-epoxide reductase, vitamin K-2,3-epoxide reductase subunit 1, vitamin K-epoxide reductase, vitamin K1 epoxide reductase, vitaminK epoxide reductase, VKOR, VKOR complex, VKORC1, VKORC1 variant 2, VKORC1-like 1, VKORC1L1, VKORC1v2, warfarin sensitive vitamin K 2,3-epoxide reductase, warfarin-sensitive vitamin K1 2,3-epoxide reductase

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.4 With a disulfide as acceptor
                1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive)

Reference

topprint

Reference on EC 1.17.4.4 - vitamin-K-epoxide reductase (warfarin-sensitive)

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Preusch, P.C.; Suttie, J.W.
Lapachol inhibition of vitamin K epoxide reductase and vitamin K quinone reductase
Arch. Biochem. Biophys.
234
405-412
1984
Rattus norvegicus, Rattus norvegicus Holtzman
Manually annotated by BRENDA team
Siegfried, C.M.
Purification and properties of a factor from rat liver cytosol which stimulates vitamin K epoxide reductase
Arch. Biochem. Biophys.
223
129-139
1983
Rattus norvegicus, Rattus norvegicus Holtzman
Manually annotated by BRENDA team
Friedman, P.A.; Griep, A.E.
In vitro inhibition of vitamin K dependent carboxylation by tetrachloropyridinol and the imidazopyridines
Biochemistry
19
3381-3386
1980
Rattus norvegicus, Rattus norvegicus Holtzman
Manually annotated by BRENDA team
Lee, J.J.; Fasco, M.J.
Metabolism of vitamin K and vitamin K 2,3-epoxide via interaction with a common disulfide
Biochemistry
23
2246-2252
1984
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Silverman, R.B.; Nandi, D.L.
Effect of N-ethylmaleimide on beef and rat liver vitamin K1 epoxide reductase
J. Enzyme Inhib.
3
289-294
1990
Bos taurus, Rattus norvegicus
Manually annotated by BRENDA team
Ryall, R.P.; Nandi, D.L.; Silverman, R.B.
Substituted vitamin K epoxide analogues. New competitive inhibitors and substrates of vitamin K1 epoxide reductase
J. Med. Chem.
33
1790-1797
1990
Bos taurus, Rattus norvegicus
Manually annotated by BRENDA team
Silverman, R.B.; Nandi, D.R.
Reduced thioredoxin: a possible physiological cofactor for vitamin K epoxide reductase. Further support for an active site disulfide
Biochem. Biophys. Res. Commun.
155
1248-1254
1988
Bos taurus, Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Soute, B.M.; Groenen-van Dooren, M.M.; Holmgren, A.; Lundström, J.; Vermeer, C.
Stimulation of the dithiol-dependent reductases in the vitamin K cycle by the thioredoxin system. Strong synergistic effects with protein disulphide-isomerase
Biochem. J.
281
255-259
1992
Bos taurus
Manually annotated by BRENDA team
Mukharji, I.; Silverman, R.B.
Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone
Proc. Natl. Acad. Sci. USA
82
2713-2717
1985
Bos taurus
Manually annotated by BRENDA team
Wallin, R.; Guenthner, T.M.
Purification of warfarin-sensitive vitamin K epoxide reductase
Methods Enzymol.
282
396-408
1997
Rattus norvegicus
-
Manually annotated by BRENDA team
Guenthner, T.M.; Cai, D.; Wallin, R.
Co-purification of microsomal epoxide hydrolase with the warfarin-sensitive vitamin K cycle
Biochem. Pharmacol.
55
169-175
1998
Rattus norvegicus
Manually annotated by BRENDA team
Begent, L.A.; Hill, A.P.; Steventon, G.B.; Hutt, A.J.; Pallister, C.J.; Cowell, D.C.
Characterization and purification of the vitamin K1 2,3 epoxide reductase system from rat liver
J. Pharm. Pharmacol.
53
481-486
2001
Rattus norvegicus
Manually annotated by BRENDA team
Hildebrandt, E.F.; Preusch.P.C.; Patterson, J.L.; Suttie, J.W.
Solubilization and characterization of vitamin K epoxide reductase from normal and warfarin-resistant rat liver microsomes
Arch. Biochem. Biophys.
228
480-492
1984
Rattus norvegicus, Rattus norvegicus Holtzman
Manually annotated by BRENDA team
Gardill, S.L.; Suttie, J.W.
Vitamin K epoxide and quinone reductase activities. Evidence for reduction by a common enzyme
Biochem. Pharmacol.
40
1055-1061
1990
Rattus norvegicus
Manually annotated by BRENDA team
Whitlon, D.S.; Sadowski, J.A.; Suttie, J.W.
Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition
Biochemistry
17
1371-1377
1978
Rattus norvegicus, Rattus norvegicus Holtzman
Manually annotated by BRENDA team
Wallin, R.; Hutson, S.M.; Cain, D.; Sweatt, a.; Sane, D.C.
A molecular mechanism for genetic warfarin resistance in the rat
FASEB J.
15
2542-2544
2001
Rattus norvegicus
Manually annotated by BRENDA team
Rost, S.; Fregin, A.; Ivaskevicius, V.; Conzelmann, E.; Hortnagel, K.; Pelz, H.J.; Lappegard, K.; Seifried, E.; Scharrer, I.; Tuddenham, E.G.; Müller, C.R.; Strom, T.M.; Oldenburg, J.
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2
Nature
427
537-541
2004
Homo sapiens (Q9BQB6), Homo sapiens
Manually annotated by BRENDA team
Li, T.; Chang, C.Y.; Jin, D.Y.; Lin, P.J.; Khvorova, A.; Stafford, D.W.
Identification of the gene for vitamin K epoxide reductase
Nature
427
541-544
2004
Homo sapiens (Q9BQB6), Homo sapiens
Manually annotated by BRENDA team
Harrington, D.J.; Underwood, S.; Morse, C.; Shearer, M.J.; Tuddenham, E.G.; Mumford, A.D.
Pharmacodynamic resistance to warfarin associated with a Val66Met substitution in vitamin K epoxide reductase complex subunit 1
Thromb. Haemost.
93
23-26
2005
Homo sapiens, Homo sapiens (Q9BQB6)
Manually annotated by BRENDA team
Wallin, R.; Sane, D.C.; Hutson, S.M.
Vitamin K 2,3-epoxide reductase and the vitamin K-dependent gamma-carboxylation system
Thromb. Res.
108
221-226
2003
Rattus norvegicus
Manually annotated by BRENDA team
Wilson, C.R.; Sauer, J.M.; Carlson, G.P.; Wallin, R.; Ward, M.P.; Hooser, S.B.
Species comparison of vitamin K1 2,3-epoxide reductase activity in vitro: kinetics and warfarin inhibition
Toxicology
189
191-198
2003
Bos taurus, Canis lupus familiaris, Equus caballus, Ovis aries, Homo sapiens, Mus musculus, Sus scrofa
Manually annotated by BRENDA team
Goodstadt, L.; Ponting, C.P.
Vitamin K epoxide reductase: homology, active site and catalytic mechanism
Trends Biochem. Sci.
29
289-292
2004
Homo sapiens
Manually annotated by BRENDA team
Wallin, R.; Hutson, S.M.
Warfarin and the vitamin K-dependent gamma-carboxylation system
Trends Mol. Med.
10
299-302
2004
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Oldenburg, J.; Bevans, C.G.; Mueller, C.R.; Watzka, M.
Vitamin K epoxide reductase complex subunit 1 (VKORC1): the key protein of the vitamin K cycle
Antioxid. Redox Signal.
8
347-353
2006
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Larramendy-Gozalo, C.; Yang, J.Q.; Verstuyft, C.; Bodin, L.; Dubert, L.; Zhang, Y.; Xu, C.; Fan, L.; Jaillon, P.; Becquemont, L.
Genetic polymorphism of vitamin K epoxide reductase (VKORC1) 1173C>T in a Chinese and a Caucasian population
Basic Clin. Pharmacol. Toxicol.
98
611-613
2006
Homo sapiens (Q9BQB6)
Manually annotated by BRENDA team
Hallgren, K.W.; Qian, W.; Yakubenko, A.V.; Runge, K.W.; Berkner, K.L.
r-VKORC1 expression in factor IX BHK cells increases the extent of factor IX carboxylation but is limited by saturation of another carboxylation component or by a shift in the rate-limiting step
Biochemistry
45
5587-5598
2006
Homo sapiens
Manually annotated by BRENDA team
Oldenburg, J.
VKORC1: The little big protein
Blood
106
3683-3684
2005
Homo sapiens
-
Manually annotated by BRENDA team
Sun, Y.M.; Jin, D.Y.; Camire, R.M.; Stafford, D.W.
Vitamin K epoxide reductase significantly improves carboxylation in a cell line overexpressing factor X
Blood
106
3811-3815
2005
Homo sapiens
Manually annotated by BRENDA team
Rettie, A.E.; Farin, F.M.; Beri, N.G.; Srinouanprachanh, S.L.; Rieder, M.J.; Thijssen, H.H.
A case study of acenocoumarol sensitivity and genotype-phenotype discordancy explained by combinations of polymorphisms in VKORC1 and CYP2C9
Br. J. Clin. Pharmacol.
62
617-620
2006
Homo sapiens
Manually annotated by BRENDA team
Deerfield, D.I.; Davis, C.H.; Wymore, T.; Stafford, D.W.; Pedersen, L.G.
Quantum chemical study of the mechanism of action of vitamin K epoxide reductase (VKOR)
Int. J. Quantum Chem.
106
2944-2952
2006
Homo sapiens
-
Manually annotated by BRENDA team
Lasseur, R.; Longin-Sauvageon, C.; Videmann, B.; Billeret, M.; Berny, P.; Benoit, E.
Warfarin resistance in a french strain of rats
J. Biochem. Mol. Toxicol.
19
379-385
2005
Rattus norvegicus, Rattus norvegicus (Q6TEK4)
Manually annotated by BRENDA team
Lasseur, R.; Grandemange, A.; Longin-Sauvageon, C.; Berny, P.; Benoit, E.
Heterogeneity of the coumarin anticoagulant targeted vitamin K epoxide reduction system. Study of kinetic parameters in susceptible and resistant mice (Mus musculus domesticus)
J. Biochem. Mol. Toxicol.
20
221-229
2006
Mus musculus, Mus musculus domesticus
Manually annotated by BRENDA team
Tie, J.K.; Nicchitta, C.; von Heijne, G.; Stafford, D.W.
Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation
J. Biol. Chem.
280
16410-16416
2005
Homo sapiens
Manually annotated by BRENDA team
Wajih, N.; Hutson, S.M.; Wallin, R.
Disulfide dependent protein folding is linked to operation of the vitamin K cycle in the endoplasmic reticulum: A protein disulfide isomerase-VKORC1 redox enzyme complex appears to be responsible for vitamin K1 2,3-epoxide reduction
J. Biol. Chem.
282
2626-2635
2006
Rattus norvegicus
Manually annotated by BRENDA team
Hatch, E.; Sconce, E.A.; Daly, A.K.; Kamali, F.
A rapid genotyping method for the vitamin K epoxide reductase complex subunit 1 (VKORC1) gene
J. Thromb. Haemost.
4
1158-1159
2006
Homo sapiens
Manually annotated by BRENDA team
Wang, Y.; Zhen, Y.; Shi, Y.; Chen, J.; Zhang, C.; Wang, X.; Yang, X.; Zheng, Y.; Liu, Y.; Hui, R.
Vitamin K epoxide reductase: a protein involved in angiogenesis
Mol. Cancer Res.
3
317-323
2005
Homo sapiens
Manually annotated by BRENDA team
Chu, P.H.; Huang, T.Y.; Williams, J.; Stafford, D.W.
Purified vitamin K epoxide reductase alone is sufficient for conversion of vitamin K epoxide to vitamin K and vitamin K to vitamin KH2
Proc. Natl. Acad. Sci. USA
103
19308-19313
2006
Homo sapiens
Manually annotated by BRENDA team
Teichert, M.; Visser, L.E.; van Schaik, R.H.; Hofman, A.; Uitterlinden, A.G.; De Smet, P.A.; Witteman, J.C.; Stricker, B.H.
Vitamin K epoxide reductase complex subunit 1 (VKORC1) polymorphism and aortic calcification: the Rotterdam Study
Arterioscler. Thromb. Vasc. Biol.
28
771-776
2008
Homo sapiens
Manually annotated by BRENDA team
Jin, D.Y.; Tie, J.K.; Stafford, D.W.
The conversion of vitamin K epoxide to vitamin K quinone and vitamin K quinone to vitamin K hydroquinone uses the same active site cysteines
Biochemistry
46
7279-7283
2007
Homo sapiens
Manually annotated by BRENDA team
Wang, D.; Chen, H.; Momary, K.M.; Cavallari, L.H.; Johnson, J.A.; Sadee, W.
Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement
Blood
112
1013-1021
2008
Homo sapiens (Q9BQB6), Homo sapiens
Manually annotated by BRENDA team
Schelleman, H.; Chen, Z.; Kealey, C.; Whitehead, A.S.; Christie, J.; Price, M.; Brensinger, C.M.; Newcomb, C.W.; Thorn, C.F.; Samaha, F.F.; Kimmel, S.E.
Warfarin response and vitamin K epoxide reductase complex 1 in African Americans and Caucasians
Clin. Pharmacol. Ther.
81
742-747
2007
Homo sapiens
Manually annotated by BRENDA team
Ainle, F.N.; Mumford, A.; Tallon, E.; McCarthy, D.; Murphy, K.
A vitamin K epoxide reductase complex subunit 1 mutation in an Irish patient with warfarin resistance
Ir. J. Med. Sci.
177
159-161
2008
Homo sapiens
Manually annotated by BRENDA team
Davis, C.H.; Deerfield, D.; Wymore, T.; Stafford, D.W.; Pedersen, L.G.
A quantum chemical study of the mechanism of action of Vitamin K epoxide reductase (VKOR) II. Transition states
J. Mol. Graph. Model.
26
401-408
2007
Homo sapiens
Manually annotated by BRENDA team
Lasseur, R.; Grandemange, A.; Longin-Sauvageon, C.; Berny, P.; Benoit, E.
Comparison of the inhibition effect of different anticoagulants on vitamin K epoxide reductase activity from warfarin-susceptible and resistant rat
Pestic. Biochem. Physiol.
88
203-208
2007
Rattus norvegicus
-
Manually annotated by BRENDA team
Rost, S.; Pelz, H.J.; Menzel, S.; MacNicoll, A.D.; Leon, V.; Song, K.J.; Jaekel, T.; Oldenburg, J.; Mueller, C.R.
Novel mutations in the VKORC1 gene of wild rats and mice--a response to 50 years of selection pressure by warfarin?
BMC Genet.
10
4-4
2009
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Song, Y.; Vera, N.; Kohn, M.H.
Vitamin K epoxide reductase complex subunit 1 (Vkorc1) haplotype diversity in mouse priority strains
BMC Res. Notes
1
125
2008
Mus musculus
Manually annotated by BRENDA team
Oner Ozgon, G.; Langaee, T.Y.; Feng, H.; Buyru, N.; Ulutin, T.; Hatemi, A.C.; Siva, A.; Saip, S.; Johnson, J.A.
VKORC1 and CYP2C9 polymorphisms are associated with warfarin dose requirements in Turkish patients
Eur. J. Clin. Pharmacol.
64
889-894
2008
Homo sapiens
Manually annotated by BRENDA team
Crosier, M.D.; Peter, I.; Booth, S.L.; Bennett, G.; Dawson-Hughes, B.; Ordovas, J.M.
Association of sequence variations in vitamin K epoxide reductase and gamma-glutamyl carboxylase genes with biochemical measures of vitamin K status
J. Nutr. Sci. Vitaminol.
55
112-119
2009
Homo sapiens (Q9BQB6), Homo sapiens
Manually annotated by BRENDA team
Grandemange, A.; Kohn, M.H.; Lasseur, R.; Longin-Sauvageon, C.; Berny, P.; Benoit, E.
Consequences of the Y139F Vkorc1 mutation on resistance to AVKs: in-vivo investigation in a 7th generation of congenic Y139F strain of rats
Pharmacogenet. Genomics
19
742-750
2009
Rattus norvegicus, Rattus norvegicus Y139F
Manually annotated by BRENDA team
Spreafico, M.; Loadigiani, C.; van Leeuwen, Y.; Pizzotti, D.; Rota, L.L.; Rosendaal, F.R.; Mannucci, P.M.; Peyvandi, F.
Effects of CYP2C9 and VKORC1 on INR variations and dose rewuirements during initial phase of anticoagulant therapy
Pharmacogenomics
9
1237-1250
2008
Homo sapiens
Manually annotated by BRENDA team
Tie, J.K.; Stafford, D.W.
Structure and function of vitamin K epoxide reductase
Vitam. Horm.
78
103-130
2008
Rattus norvegicus
Manually annotated by BRENDA team
Berkner, K.L.
Vitamin K-dependent carboxylation
Vitam. Horm.
78
131-156
2008
Homo sapiens
Manually annotated by BRENDA team
Wallin, R.; Wajih, N.; Hutson, S.M.
VKORC1: a warfarin-sensitive enzyme in vitamin K metabolism and biosynthesis of vitamin K-dependent blood coagulation factors
Vitam. Horm.
78
227-246
2008
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Garcia, A.A.; Reitsma, P.H.
VKORC1 and the vitamin K cycle
Vitam. Horm.
78
23-33
2008
Homo sapiens
Manually annotated by BRENDA team
Choppin, A.; Irwin, I.; Lach, L.; McDonald, M.G.; Rettie, A.E.; Shao, L.; Becker, C.; Palme, M.P.; Paliard, X.; Bowersox, S.; Dennis, D.M.; Druzgala, P.
Effect of tecarfarin, a novel vitamin K epoxide reductase inhibitor, on coagulation in beagle dogs
Br. J. Pharmacol.
158
1536-1547
2009
Canis lupus familiaris, Homo sapiens
Manually annotated by BRENDA team
Wang, Y.; Luo, F.; Zheng, Y.; Fan, X.; Chen, J.; Zhang, Y.; Hui, R.
VKORC1 haplotypes influence the performance characteristics of PIVKAII for screening of hepatocellular carcinoma
Clin. Chem. Lab. Med.
48
1475-1479
2010
Homo sapiens (Q9BQB6), Homo sapiens
Manually annotated by BRENDA team
Ozer, N.; Cam, N.; Tangurek, B.; Ozer, S.; Uyarel, H.; Oz, D.; Guney, M.R.; Ciloglu, F.
The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements in an adult Turkish population
Heart Vessels
25
155-162
2010
Homo sapiens
Manually annotated by BRENDA team
Rishavy, M.A.; Usubalieva, A.; Hallgren, K.W.; Berkner, K.L.
Novel insight into the mechanism of the vitamin K oxidoreductase (VKOR): electron relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K-dependent protein carboxylation
J. Biol. Chem.
286
7267-7278
2011
Homo sapiens
Manually annotated by BRENDA team
Wu, S.; Liu, S.; Davis, C.H.; Stafford, D.W.; Kulman, J.D.; Pedersen, L.G.
A hetero-dimer model for concerted action of vitamin K carboxylase and vitamin K reductase in vitamin K cycle
J. Theor. Biol.
279
143-149
2011
Homo sapiens
Manually annotated by BRENDA team
Hodroge, A.; Longin-Sauvageon, C.; Fourel, I.; Benoit, E.; Lattard, V.
Biochemical characterization of spontaneous mutants of rat VKORC1 involved in the resistance to antivitamin K anticoagulants
Arch. Biochem. Biophys.
515
14-20
2011
Rattus norvegicus, Rattus norvegicus (Q6TEK4)
Manually annotated by BRENDA team
Bevans, C.G.; Krettler, C.; Reinhart, C.; Tran, H.; Kossmann, K.; Watzka, M.; Oldenburg, J.
Determination of the warfarin inhibition constant Ki for vitamin K 2,3-epoxide reductase complex subunit-1 (VKORC1) using an in vitro DTT-driven assay
Biochim. Biophys. Acta
1830
4202-4210
2013
Homo sapiens
Manually annotated by BRENDA team
Watanabe, K.P.; Saengtienchai, A.; Tanaka, K.D.; Ikenaka, Y.; Ishizuka, M.
Comparison of warfarin sensitivity between rat and bird species
Comp. Biochem. Physiol. C
152
114-119
2010
Anas platyrhynchos, Gallus gallus, Struthio camelus, Rattus norvegicus, Bubo scandiacus, Bubo virginianus
Manually annotated by BRENDA team
Van Horn, W.D.
Structural and functional insights into human vitamin K epoxide reductase and vitamin K epoxide reductase-like1
Crit. Rev. Biochem. Mol. Biol.
48
357-372
2013
Homo sapiens, Mycobacterium tuberculosis
Manually annotated by BRENDA team
Matagrin, B.; Hodroge, A.; Montagut-Romans, A.; Andru, J.; Fourel, I.; Besse, S.; Benoit, E.; Lattard, V.
New insights into the catalytic mechanism of vitamin K epoxide reductase (VKORC1) - The catalytic properties of the major mutations of rVKORC1 explain the biological cost associated to mutations
FEBS Open Bio
3
144-150
2013
Homo sapiens
Manually annotated by BRENDA team
Tie, J.K.; Jin, D.Y.; Stafford, D.W.
Human vitamin K epoxide reductase and its bacterial homologue have different membrane topologies and reaction mechanisms
J. Biol. Chem.
287
33945-33955
2012
Homo sapiens
Manually annotated by BRENDA team
Tie, J.K.; Jin, D.Y.; Tie, K.; Stafford, D.W.
Evaluation of warfarin resistance using TALENs-mediated vitamin K epoxide reductase knockout HEK293 cells
J. Thromb. Haemost.
11
1556-1564
2013
Homo sapiens
Manually annotated by BRENDA team
Fregin, A.; Czogalla, K.J.; Gansler, J.; Rost, S.; Taverna, M.; Watzka, M.; Bevans, C.G.; Mueller, C.R.; Oldenburg, J.
A new cell culture-based assay quantifies vitamin K 2,3-epoxide reductase complex subunit 1 function and reveals warfarin resistance phenotypes not shown by the dithiothreitol-driven VKOR assay
J. Thromb. Haemost.
11
872-880
2013
Homo sapiens (Q9BQB6), Homo sapiens
Manually annotated by BRENDA team
Chen, D.; Cousins, E.; Sandford, G.; Nicholas, J.
Human herpesvirus 8 viral interleukin-6 interacts with splice variant 2 of vitamin K epoxide reductase complex subunit 1
J. Virol.
86
1577-1588
2012
Homo sapiens
Manually annotated by BRENDA team
Rutkevich, L.A.; Williams, D.B.
Vitamin K epoxide reductase contributes to protein disulfide formation and redox homeostasis within the endoplasmic reticulum
Mol. Biol. Cell
23
2017-2027
2012
Homo sapiens
Manually annotated by BRENDA team
Perez-Andreu, V.; Teruel, R.; Corral, J.; Roldan, V.; Garcia-Barbera, N.; Salloum-Asfar, S.; Gomez-Lechon, M.J.; Bourgeois, S.; Deloukas, P.; Wadelius, M.; Vicente, V.; Gonzalez-Conejero, R.; Martinez, C.
miR-133a regulates vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1), a key protein in the vitamin K cycle
Mol. Med.
18
1466-1472
2012
Homo sapiens (Q6BQB6), Homo sapiens (Q9BQB6), Homo sapiens
Manually annotated by BRENDA team
Krettler, C.; Bevans, C.G.; Reinhart, C.; Watzka, M.; Oldenburg, J.
Tris(3-hydroxypropyl)phosphine is superior to dithiothreitol for in vitro assessment of vitamin K 2,3-epoxide reductase activity
Anal. Biochem.
474
89-94
2015
Homo sapiens (Q9BQB6)
Manually annotated by BRENDA team
Holden, R.M.; Booth, S.L.; Tuttle, A.; James, P.D.; Morton, A.R.; Hopman, W.M.; Nolan, R.L.; Garland, J.S.
Sequence variation in vitamin K epoxide reductase gene is associated with survival and progressive coronary calcification in chronic kidney disease
Arterioscler. Thromb. Vasc. Biol.
34
1591-1596
2014
Homo sapiens (Q9BQB6)
Manually annotated by BRENDA team
Cao, Z.; van Lith, M.; Mitchell, L.J.; Pringle, M.A.; Inaba, K.; Bulleid, N.J.
The membrane topology of vitamin K epoxide reductase is conserved between human isoforms and the bacterial enzyme
Biochem. J.
473
851-858
2016
Homo sapiens (Q9BQB6), Homo sapiens
Manually annotated by BRENDA team
Jaenecke, F.; Friedrich-Epler, B.; Parthier, C.; Stubbs, M.T.
Membrane composition influences the activity of in vitro refolded human vitamin K epoxide reductase
Biochemistry
54
6454-6461
2015
Homo sapiens (Q9BQB6), Homo sapiens
Manually annotated by BRENDA team
Ge, B.; Zhang, Z.; Lam, T.T.; Zuo, Z.
Puerarin offsets the anticoagulation effect of warfarin in rats by inducing rCyps, upregulating vitamin K epoxide reductase and inhibiting thrombomodulin
Biopharm. Drug Dispos.
38
33-49
2017
Rattus norvegicus (Q6TEK4)
Manually annotated by BRENDA team
Czogalla, K.J.; Biswas, A.; Wendeln, A.C.; Westhofen, P.; Müller, C.R.; Watzka, M.; Oldenburg, J.
Human VKORC1 mutations cause variable degrees of 4-hydroxycoumarin resistance and affect putative warfarin binding interfaces
Blood
122
2743-2750
2013
Homo sapiens (Q9BQB6), Homo sapiens
Manually annotated by BRENDA team
Itoh, S.; Onishi, S.
Developmental changes of vitamin K epoxidase and reductase activities involved in the vitamin K cycle in human liver
Early Hum. Dev.
57
15-23
2000
Homo sapiens
Manually annotated by BRENDA team
Fernandez, I.; Vijayakumar, P.; Marques, C.; Cancela, M.L.; Gavaia, P.J.; Laize, V.
Zebrafish vitamin K epoxide reductases expression in vivo, along extracellular matrix mineralization and under phylloquinone and warfarin in vitro exposure
Fish Physiol. Biochem.
41
745-759
2015
Danio rerio (E7F6X2), Danio rerio (Q502B2)
Manually annotated by BRENDA team
Turgut Cosan, D.; Yazici, H.U.; Colak, E.; Soyocak, A.; Degirmenci, I.; Kurt, H.; Birdane, A.; Colak, E.; Gunes, H.V.
Susceptiveness of vitamin K epoxide reductase complex subunit 1 gene polymorphism in essential hypertension
Genet. Test. Mol. Biomarkers
21
292-297
2017
Homo sapiens (Q9BQB6), Homo sapiens
Manually annotated by BRENDA team
Luong, T.T.; Reardon-Robinson, M.E.; Siegel, S.D.; Ton-That, H.
Reoxidation of the thiol-disulfide oxidoreductase MdbA by a bacterial vitamin K epoxide reductase in the biofilm-forming actinobacterium actinomyces oris
J. Bacteriol.
199
e00817-16
2017
Actinomyces oris, Mycobacterium tuberculosis
Manually annotated by BRENDA team
Tie, J.K.; Jin, D.Y.; Stafford, D.W.
Conserved loop cysteines of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) are involved in its active site regeneration
J. Biol. Chem.
289
9396-9407
2014
Homo sapiens (Q8N0U8)
Manually annotated by BRENDA team
Liu, S.; Cheng, W.; Fowle Grider, R.; Shen, G.; Li, W.
Structures of an intramembrane vitamin K epoxide reductase homolog reveal control mechanisms for electron transfer
Nat. Commun.
5
3110
2014
Synechococcus sp. JA-2-3B'a(2-13) (Q2JJF6)
Manually annotated by BRENDA team
Shen, G.; Cui, W.; Zhang, H.; Zhou, F.; Huang, W.; Liu, Q.; Yang, Y.; Li, S.; Bowman, G.R.; Sadler, J.E.; Gross, M.L.; Li, W.
Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer
Nat. Struct. Mol. Biol.
24
69-76
2017
Homo sapiens (Q9BQB6), Homo sapiens
Manually annotated by BRENDA team
Bevans, C.G.; Krettler, C.; Reinhart, C.; Watzka, M.; Oldenburg, J.
Phylogeny of the vitamin K 2,3-epoxide reductase (VKOR) family and evolutionary relationship to the disulfide bond formation protein B (DsbB) family
Nutrients
7
6224-6249
2015
Homo sapiens (Q9BQB6), Homo sapiens
Manually annotated by BRENDA team
Tew, B.Y.; Hong, T.B.; Otto-Duessel, M.; Elix, C.; Castro, E.; He, M.; Wu, X.; Pal, S.K.; Kalkum, M.; Jones, J.O.
Vitamin K epoxide reductase regulation of androgen receptor activity
Oncotarget
8
13818-13831
2017
Homo sapiens (Q9BQB6), Mus musculus (Q9CRC0), Mus musculus
Manually annotated by BRENDA team
Yu, Z.B.; Yang, X.J.; Du, J.J.; Wan, C.M.; Xu, J.N.; Wang, W.J.; Feng, Y.G.; Wang, X.Y.
A homologue of vitamin K epoxide reductase in Solanum lycopersicum is involved in resistance to osmotic stress
Physiol. Plant.
156
311-322
2016
Solanum lycopersicum (K4BAJ5), Solanum lycopersicum
Manually annotated by BRENDA team
Hatahet, F.; Blazyk, J.L.; Martineau, E.; Mandela, E.; Zhao, Y.; Campbell, R.E.; Beckwith, J.; Boyd, D.
Altered Escherichia coli membrane protein assembly machinery allows proper membrane assembly of eukaryotic protein vitamin K epoxide reductase
Proc. Natl. Acad. Sci. USA
112
15184-15189
2015
Rattus norvegicus (Q6TEK4)
Manually annotated by BRENDA team
Chatron, N.; Chalmond, B.; Trouve, A.; Benoit, E.; Caruel, H.; Lattard, V.; Tchertanov, L.
Identification of the functional states of human Vitamin K epoxide reductase from molecular dynamics simulations
RSC Adv.
7
52071-52090
2017
Homo sapiens (Q9BQB6)
-
Manually annotated by BRENDA team
Sinhadri, B.C.S.; Jin, D.Y.; Stafford, D.W.; Tie, J.K.
Vitamin K epoxide reductase and its paralogous enzyme have different structures and functions
Sci. Rep.
7
17632
2017
Homo sapiens (Q9BQB6)
Manually annotated by BRENDA team
Caspers, M.; Czogalla, K.J.; Liphardt, K.; Mueller, J.; Westhofen, P.; Watzka, M.; Oldenburg, J.
Two enzymes catalyze vitamin K 2,3-epoxide reductase activity in mouse VKORC1 is highly expressed in exocrine tissues while VKORC1L1 is highly expressed in brain
Thromb. Res.
135
977-983
2015
Mus musculus (Q6TEK5), Mus musculus (Q9CRC0), Mus musculus
Manually annotated by BRENDA team