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1.17.4.4: vitamin-K-epoxide reductase (warfarin-sensitive)

This is an abbreviated version!
For detailed information about vitamin-K-epoxide reductase (warfarin-sensitive), go to the full flat file.

Word Map on EC 1.17.4.4

Reaction

phylloquinol
+
a protein with a disulfide bond
=
phylloquinone
+
a protein with reduced L-cysteine residues

Synonyms

EC 1.1.4.1, phylloquinone epoxide reductase, reductase, phylloquinone epoxide, vitamin K 2,3-epoxide reductase, vitamin K 2,3-epoxide reductase complex subunit 1, vitamin K 2,3-epoxide reductase complex subunit-1, vitamin K epoxid reductase, vitamin K epoxide reductase, vitamin K epoxide reductase complex subunit 1, vitamin K oxidoreductase, Vitamin K reductase, vitamin K-2,3-epoxide reductase, vitamin K-2,3-epoxide reductase subunit 1, vitamin K-epoxide reductase, vitamin K1 epoxide reductase, vitaminK epoxide reductase, VKOR, VKOR complex, VKORC1, VKORC1 variant 2, VKORC1-like 1, VKORC1L1, VKORC1v2, warfarin sensitive vitamin K 2,3-epoxide reductase, warfarin-sensitive vitamin K1 2,3-epoxide reductase

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.4 With a disulfide as acceptor
                1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive)

Expression

Expression on EC 1.17.4.4 - vitamin-K-epoxide reductase (warfarin-sensitive)

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression is upregulated by salt or drought stress
level of vkorc1l1 expression is the highest at 4-cell stage, diminishing at Prim-5 stage and remaining stable afterward
level of vkorc1l1 expression is the highest at 4-cell stage, diminishing at Prim-5 stage and remaining stable afterward. Significantly overexpressed in differentiating cells (T1M) but not in mineralizating (T3M) cells
micro-RNA miR-133a interacts with the 3'-UTR of VKORC1. Transfection of miRNA precursors of miR-133a in HepG2 cells reduces VKORC1 mRNA expression. miR-133a levels correlate inversely with VKORC1 mRNA levels in 23 liver samples from healthy subjects
miR-133a miRNA targeting the enzyme in HepG2 cells reduces VKORC1 mRNA expression in a dose-dependent manner, quantitative reverse transcriptase–polymerase chain reaction expression analysis. miR-133a interacts with the 3'-UTR of VKORC1
puerarin upregulates the expression in warfarin-treated rats
Vkorc1 is detected at 4-cell stage but shows an expression peak at 72-96 h post fertilization, and a lower and stable gene expression value afterward. Significantly overexpressed in differentiating (T1M) but not in mineralizating (T3M) cells