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1.17.4.2: ribonucleoside-triphosphate reductase (thioredoxin)

This is an abbreviated version!
For detailed information about ribonucleoside-triphosphate reductase (thioredoxin), go to the full flat file.

Word Map on EC 1.17.4.2

Reaction

2'-deoxyribonucleoside 5'-triphosphate
+
thioredoxin disulfide
 +
H2O
=
ribonucleoside 5'-triphosphate
 +
thioredoxin

Synonyms

2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase, adenosylcobalamin-dependent ribonucleoside-triphosphate reductase, class Ib ribonucleotide reductase, class Ib RNR, class II ribonucleotide reductase, class II RNR, class III ribonucleotide reductase, class III RNR, More, nrdD, nucleoside triphosphate reductase, ribonucleoside triphosphate reductase, ribonucleotide diphosphate reductase, ribonucleotide reductase, RNR, RNR class Ia, RNR2, RTPR

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.4 With a disulfide as acceptor
                1.17.4.2 ribonucleoside-triphosphate reductase (thioredoxin)

Source Tissue

Source Tissue on EC 1.17.4.2 - ribonucleoside-triphosphate reductase (thioredoxin)

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
fibroblast cell, non-dividing cells expressing enzyme subunit p53R2, but not sunit R2 protein, have reduced dNTP levels if exposed to the enzyme--specific inhibitor hydroxyurea. After DNA damage, a slow, up to 4fold increase in p53R2 expression leads to 3fold increase in dNTP pools in G0/G1 cells
Manually annotated by BRENDA team
-
significant induction of subunit R2 following blood feeding
Manually annotated by BRENDA team
-
isozymes R2 and p53R2
Manually annotated by BRENDA team
subunit R2 isoforms TSO2 and RNR2A
Manually annotated by BRENDA team
-
colon cancer cell. Cell line expresses subunit R2 in excess resulting in protection against DNA damage and replication stress
Manually annotated by BRENDA team
-
oropharyngeal epidermal carcinoma cell line. At G1/S phase transition, level of p53-dependent small enzyme subunit M2B increases to maximum levles, and decreases with DNA synthesis. In response to DNA replication, subunit M2B redistributes from the cytoplasm to the nucleus earlier than small subunit M2
Manually annotated by BRENDA team
cauline leaf, subunit R2 isoforms TSO2 and RNR2A
Manually annotated by BRENDA team
-
higest expression of subunit R2 in ovary of blood-fed or sugar-fed animals. Significant induction following blood feeding
Manually annotated by BRENDA team
subunit R2 isoform TSO2
Manually annotated by BRENDA team
subunit R2 isoforms TSO2 and RNR2A
Manually annotated by BRENDA team
subunit R2 isoforms TSO2 and RNR2A
Manually annotated by BRENDA team
additional information