1.17.4.1: ribonucleoside-diphosphate reductase

This is an abbreviated version!
For detailed information about ribonucleoside-diphosphate reductase, go to the full flat file.

Reaction

Synonyms

2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase, ADP reductase, CDP reductase, class I ribonucleotide reductase, class I ribonulceotide reductase, class I RNR, class I RR, class Ia ribonucleotide reductase, class Ia RNR, class Ia RR, class Ib ribonucleotide reductase, class Ib RNR, class Ic ribonucleotide reductase, class II RNR, manganese-ribonucleotide reductase, Mn-RNR, More, mRR, NrdA, NrdB, NrdE, NrdF, nucleoside diphosphate reductase, p53-inducible ribonucleotide reductase, R2F, reductase, ribonucleoside diphosphate, ribonucleoside 5'-diphosphate reductase, ribonucleoside diphosphate reductase, ribonucleoside-diphosphate reductase subunit M2 B, ribonucleotide diphosphate reductase, ribonucleotide reductase, RIR1, RIR2, RNR, RNR1 rRibonucleoside-diphosphate reductase large chain 1, RNR2, UDP reductase

ECTree

     1 Oxidoreductases

         1.17 Acting on CH or CH₂ groups

             1.17.4 With a disulfide as acceptor

                1.17.4.1 ribonucleoside-diphosphate reductase

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Results	in table
306	Activating Compound
93601	AA Sequence
18	Application
1	CAS Registry Number
42	Cloned(Commentary)
61	Cofactor
22	Crystallization (Commentary)
147	Disease/ Diagnostics
9	Expression
47	General Information
6	General Stability
27	IC50 Value
482	Inhibitors
40	Ki Value [mM]
40	KM Value [mM]
14	Localization
120	Metals/Ions
52	Molecular Weight [Da]
63	Natural Substrates/ Products (Substrates)
248	Organism
2	Oxidation Stability
18	Pathway
527	PDB ID
18	pH Optimum
2	pH Range
67	Protein Variants
47	Purification (Commentary)
26	Reaction
3	Reaction Type
237	Reference
87	Source Tissue
49	Specific Activity [micromol/min/mg]
10	Storage Stability
277	Substrates and Products (Substrate)
110	Subunits
155	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
2	Temperature Range [°C]
1	Temperature Stability [°C]
7	Turnover Number [1/s]

Synonyms

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Synonyms on EC 1.17.4.1 - ribonucleoside-diphosphate reductase

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase

-

-

-

-

ADP reductase

-

-

-

-

CDP reductase

-

-

-

-

class I ribonucleotide reductase

6 entries

class I ribonulceotide reductase

Escherichia coli

P69924

-

659447

class I RNR

9 entries

class I RR

Homo sapiens

-

-

716318

class Ia ribonucleotide reductase

Escherichia coli

-

-

715170

class Ia RNR

6 entries

class Ia RR

Mus musculus

-

-

657491

class Ib ribonucleotide reductase

12 entries

class Ib RNR

14 entries

class Ic ribonucleotide reductase

Chlamydia trachomatis

-

-

714196

class II RNR

4 entries

manganese-ribonucleotide reductase

2 entries

Mn-RNR

3 entries

mRR

Mus musculus

-

-

657491

NrdA

3 entries

NrdB

2 entries

NrdE

7 entries

NrdF

6 entries

nucleoside diphosphate reductase

-

-

-

-

p53-inducible ribonucleotide reductase

Homo sapiens

-

-

702259

R2F

2 entries

reductase, ribonucleoside diphosphate

-

-

-

-

ribonucleoside 5'-diphosphate reductase

-

-

-

-

ribonucleoside diphosphate reductase

-

-

-

-

ribonucleoside-diphosphate reductase subunit M2 B

Homo sapiens

Q7LG56

-

728677

ribonucleotide diphosphate reductase

-

-

-

-

ribonucleotide reductase

11 entries

RIR1

Corynebacterium phage P1201

-

-

727344

RIR2

Homo sapiens

P31350

-

727994

RNR

12 entries

RNR1 rRibonucleoside-diphosphate reductase large chain 1

Saccharomyces cerevisiae

P21524

-

728151

RNR2

Arabidopsis thaliana

P0DKH2, P50651, Q9LSD0

-

706318

UDP reductase

-

-

-

-

additional information

3 entries

class I ribonucleotide reductase

Chlamydia trachomatis

-

-

704612

class I ribonucleotide reductase

Escherichia coli

P69924

-

704176

class I ribonucleotide reductase

Homo sapiens

P23921

-

744359, 744958

class I ribonucleotide reductase

Homo sapiens

P23921; P31350

-

744359

class I ribonucleotide reductase

Pseudomonas aeruginosa

-

-

745325

class I ribonucleotide reductase

Saccharomyces cerevisiae

-

-

744359

class I RNR

Chlamydia trachomatis

-

-

714196

class I RNR

Chlamydia trachomatis

O84835

-

702226

class I RNR

Escherichia coli

-

-

704195, 716143, 716317

class I RNR

Escherichia coli

P69924

-

702226, 704176

class I RNR

Escherichia coli K-12 CM735

-

-

-

class I RNR

Human gammaherpesvirus 8

-

-

713645

class I RNR

Pseudomonas aeruginosa

-

-

716317, 745325

class I RNR

Pseudomonas aeruginosa

Q9I4I1

-

746517

class I RNR

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

716317

class Ia RNR

Escherichia coli

-

-

715085, 715170, 745156

class Ia RNR

Escherichia coli

P00452; P69924

-

744781, 745680

class Ia RNR

Homo sapiens

-

-

715085

class Ia RNR

Lactobacillus leichmannii

-

-

715085

class Ia RNR

Mus musculus

-

-

715085

class Ia RNR

Saccharomyces cerevisiae

-

-

715085

class Ib ribonucleotide reductase

Bacillus cereus

Q81G55

-

744357

class Ib ribonucleotide reductase

Bacillus cereus ATCC 14579

Q81G55

-

-

class Ib ribonucleotide reductase

Bacillus subtilis

-

-

714258

class Ib ribonucleotide reductase

Bacillus subtilis JH624

-

-

-

class Ib ribonucleotide reductase

Bifidobacterium longum subsp. Longum

-

-

744978

class Ib ribonucleotide reductase

Bifidobacterium longum subsp. Longum ATCC 15707

-

-

-

class Ib ribonucleotide reductase

Escherichia coli

-

-

714184, 714236

class Ib ribonucleotide reductase

Escherichia coli

P37146

-

716920

class Ib ribonucleotide reductase

Escherichia coli GR536

-

-

-

class Ib ribonucleotide reductase

Mycobacterium tuberculosis

P9WH75; P9WH73; P9WH71

-

745385

class Ib ribonucleotide reductase

Streptococcus sanguinis

A3CLZ6; A3CLZ4

-

745317

class Ib ribonucleotide reductase

Streptococcus sanguinis SK36

A3CLZ6; A3CLZ4

-

-

class Ib RNR

Bacillus cereus

-

-

702216

class Ib RNR

Bacillus subtilis

-

-

714258

class Ib RNR

Bacillus subtilis JH624

-

-

-

class Ib RNR

Bifidobacterium longum subsp. Longum

-

-

744978

class Ib RNR

Bifidobacterium longum subsp. Longum ATCC 15707

-

-

-

class Ib RNR

Escherichia coli

-

-

714184, 714236, 715085

class Ib RNR

Escherichia coli

P37146

-

716920

class Ib RNR

Escherichia coli GR536

-

-

-

class Ib RNR

Lactobacillus leichmannii

-

-

715085

class Ib RNR

Mus musculus

-

-

715085

class Ib RNR

Mycobacterium tuberculosis

P9WH75; P9WH73; P9WH71

-

745385

class Ib RNR

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

716674

class Ib RNR

Streptococcus sanguinis

A3CLZ6; A3CLZ4

-

745317

class Ib RNR

Streptococcus sanguinis SK36

A3CLZ6; A3CLZ4

-

-

class II RNR

Escherichia coli

-

cf. EC 1.17.4.2

715085

class II RNR

Lactobacillus leichmannii

-

cf. EC 1.17.4.2

715085

class II RNR

Mus musculus

-

cf. EC 1.17.4.2

715085

class II RNR

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

716317

manganese-ribonucleotide reductase

Corynebacterium glutamicum

-

-

703813

manganese-ribonucleotide reductase

Corynebacterium glutamicum R163

-

-

-

Mn-RNR

Corynebacterium ammoniagenes

-

-

701536

Mn-RNR

Corynebacterium glutamicum

-

-

703813

Mn-RNR

Corynebacterium glutamicum R163

-

-

-

NrdA

Escherichia coli

-

-

716143

NrdA

Escherichia coli

P00452

-

728670

NrdA

Escherichia coli K-12 CM735

-

-

-

NrdB

Escherichia coli

-

-

716143

NrdB

Escherichia coli K-12 CM735

-

-

-

NrdE

Bacillus anthracis

Q81G56

-

727885

NrdE

Bacillus anthracis ATCC 14579

Q81G56

-

-

NrdE

Bacillus subtilis

-

-

714258

NrdE

Bacillus subtilis JH624

-

-

-

NrdE

Escherichia coli

-

-

714184, 714236

NrdE

Escherichia coli

P39452

-

728322

NrdE

Escherichia coli GR536

-

-

-

NrdF

Bacillus cereus

Q81G55

-

744357

NrdF

Bacillus cereus ATCC 14579

Q81G55

-

-

NrdF

Bacillus subtilis

-

-

714258

NrdF

Bacillus subtilis JH624

-

-

-

NrdF

Escherichia coli

-

-

714184, 714236

NrdF

Escherichia coli GR536

-

-

-

R2F

Bacillus cereus

-

-

702216

R2F

Corynebacterium ammoniagenes

-

-

701536

ribonucleotide reductase

-

-

-

-

ribonucleotide reductase

Arabidopsis thaliana

P0DKH2, P50651, Q9LSD0

-

706318

ribonucleotide reductase

Chlamydia trachomatis

-

-

704612

ribonucleotide reductase

Corynebacterium ammoniagenes

-

-

701536

ribonucleotide reductase

Escherichia coli

-

-

659460, 676888

ribonucleotide reductase

Escherichia coli

P00452; P69924

-

744781

ribonucleotide reductase

Homo sapiens

-

-

684464, 702161, 702551, 716792

ribonucleotide reductase

Oryza sativa

Q5VRJ6, Q6K848

-

706308

ribonucleotide reductase

Plasmodium falciparum

-

-

659727

ribonucleotide reductase

Pyrococcus furiosus

E7FHX6

-

723666

ribonucleotide reductase

Saccharomyces cerevisiae

P21524

-

688286

RNR

Chlamydia trachomatis

-

-

685235, 685275, 686735, 704612

RNR

Escherichia coli

-

-

676888, 687294, 714622, 716143

RNR

Escherichia coli

P69924

-

659447

RNR

Escherichia coli K-12 CM735

-

-

-

RNR

Homo sapiens

-

-

684464, 685023, 688244, 702259

RNR

Human gammaherpesvirus 8

-

-

713645

RNR

Mus musculus

-

-

688244

RNR

Mycobacterium tuberculosis

-

-

688589

RNR

Oryza sativa

Q5VRJ6, Q6K848

-

706308

RNR

Plasmodium falciparum

-

-

659727

RNR

Pyrococcus furiosus

E7FHX6

-

723666

RNR

Saccharomyces cerevisiae

-

-

660357

additional information

Chlamydia trachomatis

-

a class I ribonucleotide reductase

686735

additional information

Chlamydia trachomatis

-

a class Ic ribonucleotide reductase

685235

additional information

Escherichia coli

-

class I ribonucleotide reductase

687294