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1.17.4.1: ribonucleoside-diphosphate reductase

This is an abbreviated version!
For detailed information about ribonucleoside-diphosphate reductase, go to the full flat file.

Word Map on EC 1.17.4.1

Reaction

2'-deoxyribonucleoside 5'-diphosphate
+
thioredoxin disulfide
+
H2O
=
ribonucleoside 5'-diphosphate
+
thioredoxin

Synonyms

2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase, ADP reductase, CDP reductase, class I ribonucleotide reductase, class I ribonulceotide reductase, class I RNR, class I RR, class Ia ribonucleotide reductase, class Ia RNR, class Ia RR, class Ib ribonucleotide reductase, class Ib RNR, class Ic ribonucleotide reductase, class II RNR, manganese-ribonucleotide reductase, Mn-RNR, More, mRR, NrdA, NrdB, NrdE, NrdF, nucleoside diphosphate reductase, p53-inducible ribonucleotide reductase, R2F, reductase, ribonucleoside diphosphate, ribonucleoside 5'-diphosphate reductase, ribonucleoside diphosphate reductase, ribonucleoside-diphosphate reductase subunit M2 B, ribonucleotide diphosphate reductase, ribonucleotide reductase, RIR1, RIR2, RNR, RNR1 rRibonucleoside-diphosphate reductase large chain 1, RNR2, UDP reductase

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.4 With a disulfide as acceptor
                1.17.4.1 ribonucleoside-diphosphate reductase

Specific Activity

Specific Activity on EC 1.17.4.1 - ribonucleoside-diphosphate reductase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0000045
-
partially purified enzyme, CDP reduction
0.00028
-
partially purified enzyme
0.0131
-
purified subunit L2 assayed in the presenc of L1
0.015
-
purified subunit L1 assayed in the presenc of L2, specific for CDP
0.0237
-
-
0.024
-
subunit Y1, expressed in Saccharomyces cerevisiae
0.035
-
recombinant R1 subunit, CDP reduction in the presence of ATP
0.048
-
recombinant DELTA1-248 R1 subunit, CDP reduction in the presence of ATP
0.062
-
M1 subunit from a mutant cell line of S49 T-lymphoma cells
0.122
-
recombinant enzyme
0.18
-
recombinant R2 subunit, CDP reduction in the presence of ATP
0.28
-
CDP reduction of subunit R1E in the presence of subunit R2F
0.3
-
His-tagged subunit Y2-K387N, expressed in Saccharomyces cerevisiae
0.51
pH 7.5, 80°C
0.53
-
subunit R2F
0.59
-
purified subunit B1
0.83
-
CDP reduction of subunit R2F in the presence of subunit R1E
1.09
Tequatrovirus T4
-
-
10000
substrate ADP, mutant R293A, pH 7.6, 30°C
106
-
iron-loaded enzyme, cosubstrate thioredoxin YosR, presence of 3 mM ATP, pH 7.6, 37°C
1100
-
mutant R265E, pH 7.5, 37°C
125
-
iron-loaded enzyme, cosubstrate thioredoxin A, presence of 3 mM ATP, pH 7.6, 37°C
146
-
manganese-loaded enzyme, cosubstrate dithiothreitol, presence of 3 mM ATP, pH 7.6, 37°C
1475
-
manganese-loaded enzyme, cosubstrate thioredoxin A, presence of 3 mM ATP, pH 7.6, 37°C
190000
substrate CDP, wild-type, pH 7.6, 30°C
2.86
-
purified subunit B2
22
-
pH 7.5, 25°C, anaerobic incubation and assay
258000
substrate ADP, wild-type, pH 7.6, 30°C
2750
-
wild-type, pH 7.5, 37°C
283
-
mutant R265A, pH 7.5, 37°C
4.21
-
recombinant subunit B2
4.3
Herpes simplex virus
-
Herpes simplex virus type 2 enzyme, CDP reduction
40000
substrate ADP, mutant Q288A, pH 7.6, 30°C
50000
substrate CDP, mutant R293A, pH 7.6, 30°C
52
-
iron-loaded enzyme, cosubstrate dithiothreitol, presence of 3 mM ATP, pH 7.6, 37°C
6.3
-
recombinant B2 subunit
60000
substrate CDP, mutant Q288A, pH 7.6, 30°C
66
-
pH 7.5, 25°C, anaerobic incubation, aerobic assay
997
-
manganese-loaded enzyme, cosubstrate thioredoxin YosR, presence of 3 mM ATP, pH 7.6, 37°C
additional information