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1.17.4.1: ribonucleoside-diphosphate reductase

This is an abbreviated version!
For detailed information about ribonucleoside-diphosphate reductase, go to the full flat file.

Word Map on EC 1.17.4.1

Reaction

2'-deoxyribonucleoside 5'-diphosphate
+
thioredoxin disulfide
+
H2O
=
ribonucleoside 5'-diphosphate
+
thioredoxin

Synonyms

2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase, ADP reductase, CDP reductase, class I ribonucleotide reductase, class I ribonulceotide reductase, class I RNR, class I RR, class Ia ribonucleotide reductase, class Ia RNR, class Ia RR, class Ib ribonucleotide reductase, class Ib RNR, class Ic ribonucleotide reductase, class II RNR, manganese-ribonucleotide reductase, Mn-RNR, More, mRR, NrdA, NrdB, NrdE, NrdF, nucleoside diphosphate reductase, p53-inducible ribonucleotide reductase, R2F, reductase, ribonucleoside diphosphate, ribonucleoside 5'-diphosphate reductase, ribonucleoside diphosphate reductase, ribonucleoside-diphosphate reductase subunit M2 B, ribonucleotide diphosphate reductase, ribonucleotide reductase, RIR1, RIR2, RNR, RNR1 rRibonucleoside-diphosphate reductase large chain 1, RNR2, UDP reductase

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.4 With a disulfide as acceptor
                1.17.4.1 ribonucleoside-diphosphate reductase

Molecular Weight

Molecular Weight on EC 1.17.4.1 - ribonucleoside-diphosphate reductase

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100000
-
alpha,beta, 1 * 100000 + 1 * 100000, Molt F4 lymphoblast cells
107000
-
4 * 107000, subunit NrdA + 4 * 47000, subunit NrdB, SDS-PAGE
125900
-
5 mM Ca2+, gel filtration
136000
Herpes simplex virus
-
1 * 136000 + 1 * 38000, molecular weight for subunit 1 deduced from sequence: 124017 Da, difference may be due to phosphorylation, SDS-PAGE
160000
250000
-
gel filtration
31000
-
4 * 37 442.98, subunit R2, mass spectrometry, 4 * 31000, recombinant subunit R2, SDS-PAGE
34000
-
x * 34000, R2F subunit, DSD-PAGE
35000
Tequatrovirus T4
-
alpha2beta2, 2 * 85000 + 2 * 35000, enzyme induced in Escherichia coli after infection with bacteriophage T4, SDS-PAGE
36000
-
alpha2,beta2, 2 * 70000 + 2 * 36000, SDS-PAGE
37900
alpha,beta2, 1 * 81200 + 2 * 37900, deduced from nucleotide sequence
38000
Herpes simplex virus
-
1 * 136000 + 1 * 38000, molecular weight for subunit 1 deduced from sequence: 124017 Da, difference may be due to phosphorylation, SDS-PAGE
39000
40600
-
alpha2,betabeta‘, 2 * 96900 (PFR1) + 1 * 40600 (PFR2) + 1 * 39000 (PFR4), SDS-PAGE
428000
tetramer, calculated from sequence
43500
Tequatrovirus T4
-
alpha2beta2, 2 * 84000 + 2 * 43500, SDS-PAGE
45000
47000
-
4 * 107000, subunit NrdA + 4 * 47000, subunit NrdB, SDS-PAGE
49600
-
isolated subunit NrdF, plus major fraction of 80100 Dalton, gel filtration
55000
-
2 * 84000 + 2 * 55000, SDS-PAGE
58000
-
x * 84000 + x * 58000, 84000 Da subunit is predominantly monomeric under experimental conditions, 58000 Da subunit may be oligomeric, SDS-PAGE
60200
-
2 * 60200, dimer appears to dissociate in the absence of Ca2+ into monomers, SDS-PAGE
70000
-
alpha2,beta2, 2 * 70000 + 2 * 36000, SDS-PAGE
75000
78000
79800
subunit NrdE, SDS-PAGE and calculated
80000
-
alpha, alpha,beta2, 2 * 80000 + 2 * 39000, SDS-PAGE
80100
-
isolated subunit NrdF, plus small fraction of 49600 Dalton, gel filtration
81200
alpha,beta2, 1 * 81200 + 2 * 37900, deduced from nucleotide sequence
82000
-
alpha,alphabeta2, 2 * 82000 + 2 * 78000, each subunit composed of 2 polypeptide chains, subunit B1, 82000 Da, sedimentation equilibrium centrifugation, subunit B2, low speed sedimentation equilibrium centrifugation
82700
-
isolated subunit NrdE
84000
85000
Tequatrovirus T4
-
alpha2beta2, 2 * 85000 + 2 * 35000, enzyme induced in Escherichia coli after infection with bacteriophage T4, SDS-PAGE
90000
96900
-
alpha2,betabeta‘, 2 * 96900 (PFR1) + 1 * 40600 (PFR2) + 1 * 39000 (PFR4), SDS-PAGE