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1.17.4.1: ribonucleoside-diphosphate reductase

This is an abbreviated version!
For detailed information about ribonucleoside-diphosphate reductase, go to the full flat file.

Word Map on EC 1.17.4.1

Reaction

2'-deoxyribonucleoside 5'-diphosphate
+
thioredoxin disulfide
 +
H2O
=
ribonucleoside 5'-diphosphate
 +
thioredoxin

Synonyms

2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase, ADP reductase, CDP reductase, class I ribonucleotide reductase, class I ribonulceotide reductase, class I RNR, class I RR, class Ia ribonucleotide reductase, class Ia RNR, class Ia RR, class Ib ribonucleotide reductase, class Ib RNR, class Ic ribonucleotide reductase, class II RNR, manganese-ribonucleotide reductase, Mn-RNR, More, mRR, NrdA, NrdB, NrdE, NrdF, nucleoside diphosphate reductase, p53-inducible ribonucleotide reductase, R2F, reductase, ribonucleoside diphosphate, ribonucleoside 5'-diphosphate reductase, ribonucleoside diphosphate reductase, ribonucleoside-diphosphate reductase subunit M2 B, ribonucleotide diphosphate reductase, ribonucleotide reductase, RIR1, RIR2, RNR, RNR1 rRibonucleoside-diphosphate reductase large chain 1, RNR2, UDP reductase

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.4 With a disulfide as acceptor
                1.17.4.1 ribonucleoside-diphosphate reductase

Expression

Expression on EC 1.17.4.1 - ribonucleoside-diphosphate reductase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
class Ib RNR is expressed under iron-limited and oxidative stress conditions
-
isoform NrdEF is induced during H2O2 stress. Induction is mediated by the inactivation of Fur, an iron-dependent repressor. NrdEF supports cell replication in iron-depleted cells. Iron binds to NrdF when it is expressed in iron-rich cells, but NrdEF is functional only in cells that are both iron-depleted and manganese-rich
ribonucleotide reductase overexpression leads to a shortened chromosome replication (C period) compared with that of a wild-type strain
ribonucleotide reductase subunit mRNA levels are comparably low in both damaged and undamaged G1 cells and highly induced in damaged S/G2 cells. Transcript numbers becomes correlated with both protein levels and localization only upon DNA damage in a cell cycle-dependent manner. The differential ribonucleotide reductase response to DNA damage correlates with variable Mec1 kinase activity in the cell cycle in single cells. The transcription of ribonucleotide reductase genes is noisy and non-Poissonian in nature
-
RNR genes are induced in cells grown in Luria-Bertani medium, with levels of NrdE and NrdF elevated 35fold relative to that of the wild-type strain
subunit RRM2B is induced in response to hypoxia
the thiazolyl hydrazone VG19 lowers the protein levels of ribonucleotide reductase subunits R1 and R2 and significantly diminishes the incorporation of radio-labeled 14C cytidine, being equivalent to an inhibition of DNA synthesis
the thiazolyl hydrazone VG19 lowers the protein levels of ribonucleotide reductase subunits R1 and R2 and significantly diminishes the incorporation of radio-labeled 14Ccytidine, being equivalent to an inhibition of DNA synthesis