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1.17.3.2: xanthine oxidase

This is an abbreviated version!
For detailed information about xanthine oxidase, go to the full flat file.

Word Map on EC 1.17.3.2

Reaction

xanthine
+
H2O
 +
O2
=
Urate
 +
H2O2

Synonyms

AXOR, EC 1.1.3.22, EC 1.2.3.2, EC 1.2.3.2., hypoxanthine oxidase, hypoxanthine-xanthine oxidase, hypoxanthine:oxygen oxidoreductase, More, oxidase, xanthine, Schardinger enzyme, xanthine dehydrogenase/oxidase, xanthine oxidase, xanthine oxidoreductase, xanthine: oxygen oxidoreductase, xanthine:O2 oxidoreductase, xanthine:oxygen oxidoreductase, xanthine:xanthine oxidase, XnOx, XO, XOD, XOR

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.3 With oxygen as acceptor
                1.17.3.2 xanthine oxidase

Application

Application on EC 1.17.3.2 - xanthine oxidase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
biotechnology
-
construction of amperometric biosensors based in xanthine oxidase which has been immobilized by covalent binding to gold electrodes modified with dithiobis-N-succinimidyl propionate. Redox dyes thionine and methylene blue work well as electron acceptors for reduced enzyme
diagnostics
-
the enzyme activity detection in sepsis can be used for a negative prognosis in sepsis diagnosis, overview
drug development
the enzyme is a target for rational design of flavonoid-type inhibitors against xanthine oxidase useful for the treatment of hyperuricemia, gout, and inflammatory disease states
medicine
pharmacology
synthesis
-
the enzyme can be used for production of superoxide, from oxidation of an aldehyde, which in a co-oxidation system reacts with the aldehyde and converts beta-carotene to beta-ionone, method optimization, overview