1.17.1.8: 4-hydroxy-tetrahydrodipicolinate reductase

This is an abbreviated version!
For detailed information about 4-hydroxy-tetrahydrodipicolinate reductase, go to the full flat file.

Reaction

Synonyms

AbDHDPR, CRR1, DapB, DHDP reductase, DHDPR, DHPR, dihydrodipicolinate reductase, dihydrodipicolinate reductase-like protein, dihydrodipicolinic acid reductase, EC 1.3.1.26, MRSA-DHDPR, reductase, dihydrodipicolinate

ECTree

     1 Oxidoreductases

         1.17 Acting on CH or CH₂ groups

             1.17.1 With NAD⁺ or NADP⁺ as acceptor

                1.17.1.8 4-hydroxy-tetrahydrodipicolinate reductase

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8	Activating Compound
36207	AA Sequence
6	Application
1	CAS Registry Number
26	Cloned(Commentary)
65	Cofactor
16	Crystallization (Commentary)
18	General Information
61	Inhibitors
15	Ki Value [mM]
60	KM Value [mM]
3	Localization
31	Molecular Weight [Da]
39	Natural Substrates/ Products (Substrates)
76	Organism
11	Pathway
56	PDB ID
13	pH Optimum
3	pH Range
7	Protein Variants
24	Purification (Commentary)
13	Reaction
3	Reaction Type
59	Reference
3	Source Tissue
16	Specific Activity [micromol/min/mg]
2	Storage Stability
100	Substrates and Products (Substrate)
38	Subunits
71	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
17	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.17.1.8 - 4-hydroxy-tetrahydrodipicolinate reductase

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SYSTEMATIC NAME

IUBMB Comments

(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate:NAD(P)+ 4-oxidoreductase

The substrate of the enzyme was initially thought to be (S)-2,3-dihydrodipicolinate [1], and the enzyme was classified accordingly as EC 1.3.1.26, dihydrodipicolinate reductase. Later studies of the enzyme from the bacterium Escherichia coli have suggested that the actual substrate of the enzyme is (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate, and that its activity includes a dehydration step [2], and thus the enzyme has been reclassified as 4-hydroxy-tetrahydrodipicolinate reductase. However, the identity of the substrate is still controversial, as more recently it has been suggested that it may be (S)-2,3-dihydrodipicolinate after all [3].