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1.17.1.5: nicotinate dehydrogenase

This is an abbreviated version!
For detailed information about nicotinate dehydrogenase, go to the full flat file.

Word Map on EC 1.17.1.5

Reaction

nicotinate
+
H2O
+
NADP+
=
6-Hydroxynicotinate
+
NADPH
+
H+

Synonyms

dehydrogenase, nicotinate, EC 1.5.1.13, NA hydroxylase, NAH, NahAB1B2, NDH, NdhL, NdhM, NdhS, nicotinate dehydrogenase, nicotinic acid hydroxylase, three-component NA hydroxylase, three-component nicotinic acid hydroxylase

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.1 With NAD+ or NADP+ as acceptor
                1.17.1.5 nicotinate dehydrogenase

Systematic Name

Systematic Name on EC 1.17.1.5 - nicotinate dehydrogenase

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SYSTEMATIC NAME
IUBMB Comments
nicotinate:NADP+ 6-oxidoreductase (hydroxylating)
A flavoprotein containing non-heme iron. The enzyme is capable of acting on a variety of nicotinate analogues to varying degrees, including pyrazine-2-carboxylate, pyrazine 2,3-dicarboxylate, trigonelline and 6-methylnicotinate. The enzyme from Clostridium barkeri also possesses a catalytically essential, labile selenium that can be removed by reaction with cyanide.