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1.17.1.4: xanthine dehydrogenase

This is an abbreviated version!
For detailed information about xanthine dehydrogenase, go to the full flat file.

Word Map on EC 1.17.1.4

Reaction

xanthine
+
NAD+
+
H2O
=
Urate
+
NADH
+
H+

Synonyms

AtXDH1, EC 1.1.1.204, EC 1.2.1.37, IAO1, More, NAD-xanthine dehydrogenase, PaoABC, Retinol dehydrogenase, Rosy locus protein, VvXDH, xanthine dehydrogenase, xanthine dehydrogenase-1, xanthine dehydrogenase-2, xanthine dehydrogenase/oxidase, xanthine oxidoreductase, xanthine-NAD oxidoreductase, xanthine/NAD+ oxidoreductase, xanthine:NAD+ oxidoreductase, XDH, XDH/XO, XDH1, XDH2, XdhC, XOR, YagR, YagS, YagT

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.1 With NAD+ or NADP+ as acceptor
                1.17.1.4 xanthine dehydrogenase

pH Stability

pH Stability on EC 1.17.1.4 - xanthine dehydrogenase

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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
11
-
no effect on activity
644574
4 - 11.5
O54050; O54051; Q9X7K2
both the recombinant split variants display similar bell-shaped pH-activity relationships with the optimum activity at pH 8.5 and remain stable in buffers ranging from pH 4.0-11.5 after incubation at 25°C for 24 h
744255
7
-
unstable below, stabilized and activated at higher pH values
644597
7 - 12
-
stable for 24 h if stored at 4°C
644616
7 - 8.5
-
stable within, loss of activity at more acidic pHs
644607
7.5
-
stable at 4°C, one day, absence of DTT
644588
8.5
-
4°C, absence of DTT, marked decrease of activity within hours
644588
9.2
-
recombinant enzyme, half-life: 10-15 h at 0-4°C
644560