1.17.1.4: xanthine dehydrogenase

This is an abbreviated version!
For detailed information about xanthine dehydrogenase, go to the full flat file.

Reaction

Synonyms

AtXDH1, EC 1.1.1.204, EC 1.2.1.37, IAO1, More, NAD-xanthine dehydrogenase, PaoABC, Retinol dehydrogenase, Rosy locus protein, VvXDH, xanthine dehydrogenase, xanthine dehydrogenase-1, xanthine dehydrogenase-2, xanthine dehydrogenase/oxidase, xanthine oxidoreductase, xanthine-NAD oxidoreductase, xanthine/NAD+ oxidoreductase, xanthine:NAD+ oxidoreductase, XDH, XDH/XO, XDH1, XDH2, XdhC, XOR, YagR, YagS, YagT

ECTree

     1 Oxidoreductases

         1.17 Acting on CH or CH₂ groups

             1.17.1 With NAD⁺ or NADP⁺ as acceptor

                1.17.1.4 xanthine dehydrogenase

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Results	in table
22	Activating Compound
13818	AA Sequence
34	Application
1	CAS Registry Number
36	Cloned(Commentary)
299	Cofactor
22	Crystallization (Commentary)
40	Disease/ Diagnostics
3	Expression
84	General Information
9	General Stability
175	Inhibitors
19	kcat/KM [mM/s]
3	Ki Value [mM]
170	KM Value [mM]
22	Localization
133	Metals/Ions
86	Molecular Weight [Da]
237	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
225	Organism
1	Oxidation Stability
14	Pathway
110	PDB ID
45	pH Optimum
8	pH Range
8	pH Stability
1	pI Value
4	Posttranslational Modification
79	Protein Variants
71	Purification (Commentary)
9	Reaction
3	Reaction Type
205	Reference
2	Renatured (Commentary)
217	Source Tissue
65	Specific Activity [micromol/min/mg]
8	Storage Stability
572	Substrates and Products (Substrate)
66	Subunits
107	Synonyms
1	Systematic Name
32	Temperature Optimum [°C]
1	Temperature Range [°C]
22	Temperature Stability [°C]
55	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.17.1.4 - xanthine dehydrogenase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

4,4'-dithiodipyridine

Bos taurus

-

reverses conversion of dehydrogenase to oxidase form

644588

4-chloromercuribenzoate

Rattus sp.

-

increases total activity up to 0.005 mM

644600

allopurinol

Gallus gallus

-

inhibits xanthine and hypoxanthine oxidation in vivo in intestine and pancreas, but enhances the activity in liver, tissue-dependent effects, overview

703310

cellular retinol binding protein

Homo sapiens

-

CRBP and CRABP, strictly dependent on

704842

-

dithioerythritol

Rattus sp.

-

recovery from oxidase to dehydrogenase type

644582

DTT

2 entries

Ferredoxin

Veillonella atypica

-

26fold increase of cytochrome c reduction, 2fold increase of oxygen reduction

644597

-

KCl

Streptomyces cyanogenus

-

strong activation at 50 mM

644616

methylene blue

Rattus sp.

-

6fold activation of aerobic rate of oxidation of xanthine

644580

NaCl

Streptomyces cyanogenus

-

nearly 2fold activation at 100 mM

644616

NAD+

Rattus sp.

-

6fold stimulation of aerobic rate of oxidation of xanthine

644580

NH4Cl

Streptomyces cyanogenus

-

2.5fold activation at 100 mM

644616

PD98059

Rattus norvegicus

-

inhibitor used to block MEK-1/2 kinase, activates the promoter of xanthine oxidoreductase and significantly enhances expression of enzyme induced by insulin, acute phase cytokines, or growth factors

675020

sodium nitroprusside

Rattus norvegicus

-

i.e. SNP, a NO donor, activates at concentrations of up to 3 mM, preventable by hemoglobin, overview

702963

sulfide/dithionite

Arabidopsis thaliana

Q8GUQ8

treatment increases the specific activity of AtXDH1

706259

-

thiol active compounds

2 entries

-

Urate

Triticum aestivum

-

30% activation of hypoxanthine-NAD+ activity

644568

additional information

Rhodobacter capsulatus

-

activation mechanism based on the results of mutations at the positions of the second Glu and Arg residues, overview

703626

-

DTT

Bos taurus

-

recovery from oxidase to dehydrogenase type

644587, 644588, 644618

DTT

Rattus sp.

-

recovery from oxidase to dehydrogenase type

644587

thiol active compounds

Bos taurus

-

reversible conversion of xanthine dehydrogenase to xanthine oxidase by modification of C535 and C992 and formation of a disulfide bond, that induces a conformational change

644564

-

thiol active compounds

Mus musculus

-

conversion of oxidase to dehydrogenase form

644565

-