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1.16.3.1: ferroxidase

This is an abbreviated version!
For detailed information about ferroxidase, go to the full flat file.

Word Map on EC 1.16.3.1

Reaction

4 Fe(II) + 4 H+ +

O2
= 4 Fe(III) + 2 H2O

Synonyms

AfFtn, apoferritin, bacterial ferritin, bacterial ferroxidase, bacterioferritin, bacterioferritin B, BFR, BfrB, blue copper oxidase, caeruloplasmin, ceruloplasmin, Cp115, Cp135, Cp200, CT1740, CtFtn, cyto-FOX, cytosolic FOX, DdBfr, Dpr, Dps, Dps protein, Dps-like peroxide resistance protein, Dps-Te, DpsA, DpsA-Te, DspA, EncA, encapsulin, encapsulin A, ferritin, ferro-O2-oxidoreductase, ferro:O2 oxidoreductase, ferroxidase, ferroxidase center of bacterioferritin, ferroxidase I, ferroxidase II, ferroxidase, iron II:oxygen oxidoreductase, Fet3, FET3 gene product, fet3p, FOX1, Ftn, FtnA, H ferritin, H' ferritin, H-chain ferritin, Helicobacter pylori neutrophil-activating protein, hephaestin, HP-NAP, HuHF, human ceruloplasmin form I, human H ferritin, human H-chain ferritin, iron(II): oxygen oxidoreductase, L-ferritin, M ferritin, MaDps, MCO1, MmcO, mnxDEFG, monophenol-o-monoxygenase, More, mouse ceruloplasmin, multicopper ferroxidase, multicopper oxidase, multicopper oxidase 1, multicopper oxidase CueO, multicopper oxidase-1, mushroom tyrosinase, mycobacterial multicopper oxidase, neutrophil-activating protein, non-ceruloplasmin ferroxidase, non-specific DNA-binding protein Dps/ferroxidase, rhHp, rHuHF, Rv0846c, serum ferroxidase, VcDps, VCE_000308, xanthine oxidoreductase

ECTree

     1 Oxidoreductases
         1.16 Oxidizing metal ions
             1.16.3 With oxygen as acceptor
                1.16.3.1 ferroxidase

Inhibitors

Inhibitors on EC 1.16.3.1 - ferroxidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6-aminohexanoic acid
-
-
Ba2+
-
weak inhibitor
Bathocuproine disulfonate
-
incubation of C6 glioma cells with the copper chelator bathocuproine disulfonate prevents expression of ceruloplasmin on the cell surface and leads to a decrease in cellular ceruloplasmin. Incubation of cells with bathocuproine disulfonate also reduces the ability of cells to lower their ferritin levels
bathocuproinedisulfonic acid
-
-
Ca2+
-
weak inhibitor
catalase
-
catalase in the assay system results in little inhibition of the ferroxidase activity of xanthine oxidoreductase
-
Cr3+
-
strong inhibitor
fluoride
-
treatment of rabbits with standard common rabbit diet and water ad libitum containing 40 mg fluoride per liter results in significant decrease of ceruloplasmin level in serum by days 35 and 70, with concomitant increase of serum adenosine eaminase and C-reactive protein
GdnHCl
recombinant wild-type rCtFtn and mutant A19Y are stable at up to 2 M GdnHCl. At 2.5 M GdnHCl both proteins start to loose structural stability
K+
-
weak inhibitor
Li+
-
weak inhibitor
N3-
-
anion behaves as an inhibitor of the oxidase activity versus Fe2+
Na+
-
weak inhibitor
NaN3
efficient inhibition
SDS
-
enzymatic activity inhibited with 1% SDS
Sn2+
-
weak inhibitor
Sodium azide
Superoxide dismutase
-
superoxide dismutase in the assay system results in little inhibition of the ferroxidase activity of xanthine oxidoreductase
-
terbium
above 0.2 mM, complete abolition of iron binding. Crystal structure of enzyme complex at 2.1 A resolution, terbium binds to the ferroxidase center
ZrO2+
additional information
-
core glycosylation suppresses Fet3p nascent chain aggregation during synthesis into the endoplasmic reticulum
-