1.16.1.8: [methionine synthase] reductase
This is an abbreviated version!
For detailed information about [methionine synthase] reductase, go to the full flat file.
Word Map on EC 1.16.1.8
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1.16.1.8
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mthfr
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folate
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methylenetetrahydrofolate
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case-control
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gg
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hyperhomocysteinemia
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one-carbon
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cystathionine
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tetrahydrofolate
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folic
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remethylation
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thymidylate
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beta-synthase
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transcobalamin
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methylmalonic
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megaloblastic
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folate-related
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spina
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bifida
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cobiialamin
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methyltetrahydrofolate
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cobalamin-dependent
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homocystinuria
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gcpii
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diagnostics
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t-hcys
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medicine
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folate-metabolizing
- 1.16.1.8
- mthfr
- folate
- methylenetetrahydrofolate
-
case-control
- gg
- hyperhomocysteinemia
-
one-carbon
- cystathionine
- tetrahydrofolate
-
folic
-
remethylation
- thymidylate
- beta-synthase
-
transcobalamin
-
methylmalonic
-
megaloblastic
-
folate-related
-
spina
- bifida
-
cobiialamin
- methyltetrahydrofolate
-
cobalamin-dependent
- homocystinuria
- gcpii
- diagnostics
-
t-hcys
- medicine
-
folate-metabolizing
Reaction
2 [methionine synthase]-methylcob(III)alamin + 2 S-adenosyl-L-homocysteine + = 2 [methionine synthase]-cob(II)alamin + + + 2 S-adenosyl-L-methionine
Synonyms
EC 2.1.1.135, Methionine synthase cob(II)alamin reductase (methylating), Methionine synthase reductase, MSR, MTRR, NADPH-dependent diflavin oxidoreductase, Reductase, methionine synthase
ECTree
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General Information
General Information on EC 1.16.1.8 - [methionine synthase] reductase
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malfunction
metabolism
physiological function
additional information
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the c.56+781 A>C (rs326119) variant of intron-1 of MTRR significantly increases the risk of congenital heart disease in the Han Chinese population and is highly related to septation defects. The c.56+781 C allele profoundly decreases MTRR transcription. Phenotype, overview
malfunction
analysis of correlations of single nucleotide polymorphisms and various malformation anomalies, overview
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the MTRR gene is involved in tumorigenesis by regulating DNA methylation through activation of methionine synthase
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methionine synthase reductase is essential for the adequate remethylation of homocysteine, which is the dominant pathway for homocysteine removal during early embryonic development
physiological function
methionine synthase reductase, a diflavin oxidoreductase, plays a vital role in methionine and folate metabolism by sustaining methionine synthase activity
physiological function
roles of methionine synthase, MS, and methylenetetrahydrofolate reductase, MTHFR, and methionine synthase reductase, MTRR, in the folate cycle and homocysteine remethylation, overview
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genotyping for the A66G polymorphism and analysis of the association with cancer risk reveals that the G allele and GG variant genotypes are associated with a significantly increased cancer risk
additional information
effects of the MTRR genotype on human status with respect to vitmain B6, plasma folate, homocysteine, and plasma cobalamine levels, modeling, detailed overview