1.16.1.1: mercury(II) reductase

This is an abbreviated version!
For detailed information about mercury(II) reductase, go to the full flat file.

Word Map on EC 1.16.1.1

1.16.1.1

organomercurial

mercury-resistant

hgcl2

methylmercury

lipoamide

phytoremediation

mercury-contaminated

ferrooxidans

hg-resistant

geothermal

metal-resistant

phenylmercury

mercury-polluted

environmental protection

Reaction

Synonyms

bacterial mercuric reductase, Mer A, MerA, MerA protein, mercurate(II) reductase, mercuric (II) reductase, mercuric ion reductase, mercuric reductase, mercury reductase, Msed_1241, MseMerA, reduced NADP:mercuric ion oxidoreductase, reductase, mercurate(II), Rm CH34, Tn501 MerA, Tn501 mercuric ion reductase

ECTree

1 Oxidoreductases

1.16 Oxidizing metal ions

1.16.1 With NAD⁺ or NADP⁺ as acceptor

1.16.1.1 mercury(II) reductase

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Results	in table
20	Activating Compound
6363	AA Sequence
8	Application
1	CAS Registry Number
53	Cloned(Commentary)
197	Cofactor
4	Crystallization (Commentary)
7	Expression
25	General Information
3	General Stability
1	IC50 Value
59	Inhibitors
1	kcat/KM [mM/s]
3	Ki Value [mM]
33	KM Value [mM]
2	Localization
5	Metals/Ions
26	Molecular Weight [Da]
74	Natural Substrates/ Products (Substrates)
209	Organism
1	Oxidation Stability
3	Pathway
12	PDB ID
17	pH Optimum
4	pH Range
2	pI Value
33	Protein Variants
18	Purification (Commentary)
5	Reaction
1	Reaction Type
172	Reference
14	Source Tissue
10	Specific Activity [micromol/min/mg]
1	Storage Stability
217	Substrates and Products (Substrate)
43	Subunits
140	Synonyms
1	Systematic Name
19	Temperature Optimum [°C]
3	Temperature Range [°C]
10	Temperature Stability [°C]
15	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.16.1.1 - mercury(II) reductase

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2-meracptoethanol

Lysinibacillus sphaericus

D9J041

activates at 0.5-1.0 mM

744471

2-mercaptoethanol

6 entries

cysteine

3 entries

dithiothreitol

Acidithiobacillus ferrooxidans

thiol compound required

438065

EDTA

3 entries

NADP+

2 entries

NADPH

Pseudomonas aeruginosa

100 microM, 30 min preincubation, relative initial rate 151%, 10 min preincubation with NADPH results in an increase of reactive thiol groups

438069

thioglycolate

Acidithiobacillus ferrooxidans

thiol compound required

438065

thiol

Escherichia coli

exogenous thiols are required for catalytic reduction of Hg(II) to Hg2+, due to prevention or reversal of formation of an abortive complex of Hg(II) with the thiol/thiolate pair of two-electron reduced enzyme

438070

additional information

Pseudomonas aeruginosa

0.1 mM NADP+ stimulates the 2,4,6-trinitrobenzenesulfonate-dependent NADPH oxidation more than 10fold

438075