Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.15.1.1: superoxide dismutase

This is an abbreviated version!
For detailed information about superoxide dismutase, go to the full flat file.

Word Map on EC 1.15.1.1

Reaction

2 superoxide + 2 H+ =

O2
+
H2O2

Synonyms

AhSOD, alr2938, AmSOD, APE0743, ApMn-SOD1, ApMn-SOD2, ASAC_0498, Ca-Cu,Zn SOD, cambialistic superoxide dismutase, Cg-EcSOD, chloroplastic Fe-SOD, Cj-Cu, Zn SOD, cMn-SOD, cMnSOD, cold-active superoxide dismutase, copper, zinc superoxide dismutase, copper-zinc superoxide dismutase, copper/zinc superoxide dismutase, copper/zinc-superoxide dismutase, CpSOD, CSD1, CSD2, CtSOD, Cu, Zn SOD, Cu, Zn superoxide dismutase, Cu, Zn-superoxide dismutase, Cu, ZnSOD, Cu,Zn superoxide dismutase, Cu,Zn-SOD, Cu,Zn-superoxide dismutase, Cu,ZnSOD, Cu-Zn SOD, Cu-Zn superoxide dismutase, Cu-Zn-SOD, Cu/Zn SOD, Cu/Zn superoxide dismutase, Cu/Zn superoxide dismutase 1, Cu/Zn-SOD, Cu/Zn-SODI, Cu/Zn-SODII, Cu/Zn-superoxide dismutase, Cu/ZnSOD, cuprein, CuZn superoxide dismutase, CuZn superoxide dismutase 1, CuZn-SOD, CuZn-superoxide dismutase, CuZnSOD, cytMnSOD, cytocuprein, cytoplasmic manganese SOD, cytosolic Cu/Zn superoxide dismutase, cytosolic Cu/Zn-SOD, cytosolic manganese superoxide dismutase, DaSOD, dhsod-1, dismutase, superoxide, EC-SOD, ecCuZnSOD, ECSOD, ElFe-SOD, ElSOD, erythrocuprein, erythrocyte superoxide dismutase, eSOD, extracellular copper-zinc superoxide dismutase, extracellular CuZnSOD, extracellular SOD, extracellular superoxide dismutase, Fe-SOD, Fe-SODe, Fe-SOD_ASAC, Fe-superoxide dismutase, Fe-type SOD, Fe/Mn-SOD, Fe/Mn-type SOD, Fe/MnSOD, ferrisuperoxide dismutase, FeSOD, GTNG_2884, hEC-SOD, hemocuprein, hepatocuprein, high isoelectric point superoxide dismutase, intracellular Cu-Zn superoxide dismutase, iron SOD, iron SOD type, iron superoxide dismutase, iron-containing superoxide dismutase, iron-dependent superoxide dismutase, iron-superoxide dismutase, KmSod1p, LSOD, manganese superoxide dismutase, manganese-containing SOD, manganese-containing superoxide dismutase, MgMnSOD1, MgMnSOD2, mitMn-SOD, mitochondrial manganese superoxide dismutase, mMnSOD, Mn-containing superoxide dismutase, Mn-SOD, Mn-type SOD, Mn/Fe superoxide dismutase, MnSOD, MnSOD-2, MnSOD-3, MnSOD1, MnSOD47, More, mtMnSOD, mtSOD, nectarin I, neelaredoxin, Nlr, Of-cCu/ZnSOD, PASOD, perMn-SOD, pfSOD, PschSOD, PsSOD, PthipI-SODC, PthipI-SODC1, PthipI-SODC2, RmFeSOD, RsrSOD, SaCSD1, SaFe-SOD, sdB, SOD, SOD 1, SOD I, SOD-1, SOD-2, SOD-3, SOD-4, SOD1, SOD2, SOD3, SODA, SodB, SODB1, SODB2, SodC, SODF, SODI, SODII, SODIII, SODIV, SODS, SSO0316, superoxide dismutase, superoxide dismutase 1, superoxide dismutase I, superoxide dismutase II, superoxide dismutase [Cu-Zn]

ECTree

     1 Oxidoreductases
         1.15 Acting on superoxide as acceptor
             1.15.1 Acting on superoxide as acceptor (only sub-subclass identified to date)
                1.15.1.1 superoxide dismutase

General Stability

General Stability on EC 1.15.1.1 - superoxide dismutase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
1 cycle of freezing and thawing causes 30% loss of activity
-
3 cycles of freezing and thawing cause less than 20% loss of activity, Mn-SOD
-
a stable SOD in a broad pH range from 4 to 12, higher temperature, and in the presence of proteases
-
activity of the SOD remains intact both in crude and purified forms after autoclaving at 6-20 bars up to 10 min and microwaving at a frequency of 2450 MHz or million cycles per second for 1-3 min
-
dimeric form is more stable against proteolysis than monomeric form
dimethyl sulfoxide: Spirulina enzyme is stable up to 55%, Rhodopseudomonas enzyme up to 70% v/v
due to high salt requirement for enzyme stability purification is performed in presence of 2 M NaCl
-
freezing causes rapid deterioation
-
guanidinium chloride: 6 M, pH 7.5, 16 h, 23°C, stable
-
incubation with proteases (e.g. trypsin, V8 Staphylococcus aureus protease) has no effect on this enzyme
lyophilization: less than 10% loss of activity
-
polyethylene glycol stabilizes
-
polyvinylchloride stabilizes the enzyme
-
quite stable to freezing
-
SDS decreases the stability of SOD and accelerates enzyme inactivation
-
SDS, 1%, complete loss of activity after 6 h
-
the enzyme is remarkably stable at high temperatures and even under denaturing conditions
-
the enzyme is stable in presence of 4% SDS
the purified enzyme is stable in 6 M guanidinium chloride for 72 h loosing only 33% activity
the purified recombinant enzyme is stable to proteolytic digestion
treatment with the proteases V8 shows no effect on the enzyme
treatment with trypsin shows little effect on the enzyme
urea: 8 M, 0°C, isoenzyme I unfolds immediately, isoenzyme II stays folded
-
urea: 8 M, pH 7.5, 16 h, 23°C, stable
-
urea: 8 M, stable
-