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1.14.99.48: heme oxygenase (staphylobilin-producing)

This is an abbreviated version!
For detailed information about heme oxygenase (staphylobilin-producing), go to the full flat file.

Word Map on EC 1.14.99.48

Reaction

protoheme
+ 5 reduced acceptor + 4 O2 =
beta-staphylobilin
 +
Fe2+
 +
formaldehyde
 + 5 acceptor + 4 H2O

Synonyms

haem oxidase, haem oxygenase, heme oxidase, heme oxygenase, heme oxygenase (decyclizing), heme oxygenase (staphylobilin-producing) 1, heme oxygenase (staphylobilin-producing) 2, isdG, isdI

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.99 Miscellaneous
                1.14.99.48 heme oxygenase (staphylobilin-producing)

Engineering

Engineering on EC 1.14.99.48 - heme oxygenase (staphylobilin-producing)

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
F23A
mutation does not significantly affect heme binding or degradation
H77A
mutation abolishes IsdG-mediated heme degradation
L17A
mutation does not significantly affect heme binding or degradation
M38A
slight reduction of heme degradation, mutation shifts the peak absorbance of the Soret band to 430 nm
S70A
mutation does not significantly affect heme binding or degradation
W66A
Trp66 is a conserved heme pocket residue implicated in heme ruffling. Mutant is inactive
W66F
Trp66 is a conserved heme pocket residue implicated in heme ruffling. Mutant shows about half of wild-type heme degradation activity
W66L
Trp66 is a conserved heme pocket residue implicated in heme ruffling. Mutant is inactive
W66Y
Trp66 is a conserved heme pocket residue implicated in heme ruffling. Mutant shows about half of wild-type heme degradation activity
W67A
mutation abolishes IsdG-mediated heme degradation
H77A
-
mutation abolishes IsdG-mediated heme degradation
-
L17A
-
mutation does not significantly affect heme binding or degradation
-
N7A
-
mutation abolishes IsdG-mediated heme degradation
-
S70A
-
mutation does not significantly affect heme binding or degradation
-
W67A
-
mutation abolishes IsdG-mediated heme degradation
-
W66A
-
Trp66 is a conserved heme pocket residue implicated in heme ruffling. Mutant is inactive
-
W66F
-
Trp66 is a conserved heme pocket residue implicated in heme ruffling. Mutant shows about half of wild-type heme degradation activity
-
W66L
-
Trp66 is a conserved heme pocket residue implicated in heme ruffling. Mutant is inactive
-
W66Y
-
Trp66 is a conserved heme pocket residue implicated in heme ruffling. Mutant shows about half of wild-type heme degradation activity
-