1.14.99.46: pyrimidine oxygenase

This is an abbreviated version!
For detailed information about pyrimidine oxygenase, go to the full flat file.

Reaction

Synonyms

RutA

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.99 Miscellaneous

                1.14.99.46 pyrimidine oxygenase

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Results	in table
2146	AA Sequence
2	Cloned(Commentary)
5	Cofactor
1	Crystallization (Commentary)
5	General Information
7	Natural Substrates/ Products (Substrates)
3	Organism
3	Pathway
8	PDB ID
1	pH Optimum
2	Purification (Commentary)
6	Reaction
3	Reference
10	Substrates and Products (Substrate)
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Reaction

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Reaction on EC 1.14.99.46 - pyrimidine oxygenase

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

FMN-N5-oxide + NADH = FMN + H2O + NAD+ + H+

2 entries

thymine + FMNH2 + O2 + NADH = (Z)-2-methylureidoacrylate + H2O + FMN + NAD+ + H+

(2) overall reaction

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thymine + FMNH2 + O2 = (Z)-2-methylureidoacrylate + FMN-N5-oxide

(2a)

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uracil + FMNH2 + O2 + NADH = (Z)-3-ureidoacrylate + H2O + FMN + NAD+ + H+

(1) overall reaction

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uracil + FMNH2 + O2 = (Z)-3-ureidoacrylate + FMN-N5-oxide

(1a)

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FMN-N5-oxide + NADH = FMN + H2O + NAD+ + H+

(1c), spontaneous

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FMN-N5-oxide + NADH = FMN + H2O + NAD+ + H+

(2b), spontaneous

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