1.14.99.4: progesterone monooxygenase
This is an abbreviated version!
For detailed information about progesterone monooxygenase, go to the full flat file.
Word Map on EC 1.14.99.4
Reaction
Synonyms
17alpha-progesterone hydroxylase, 17beta-progesterone hydroxylase, CYP2G1, cytochrome P-450/monooxygenase, FMO, progesterone hydroxylase
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Substrates Products on EC 1.14.99.4 - progesterone monooxygenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
16alpha,17alpha-oxidopregn-4-ene-3,20-dione + NADPH + O2
16alpha-hydroxyandrost-4-ene-3,17-dione
17alpha-methylpregn-4-ene-3,20-dione + NADPH + O2
?
-
about 4.3% the rate of the reaction with progesterone
-
-
?
pregna-4,16-diene-3,20-dione + NADPH + O2
androst-4-ene-3,17-dione
-
degradation of pregnane side chains, about 104% the rate of the reaction with progesterone
-
?
progesterone + NADPH + H+ + O2
16alpha-hydroxyprogesterone + 2beta,16alpha-dihydroxyprogesterone + NADP+ + H2O
-
-
-
?
testosterone + reduced acceptor + O2
15alpha-hydroxytestosterone + 15beta-hydroxytestosterone + 2beta-hydroxytestosterone + acceptor + H2O
-
-
-
-
r
16alpha,17alpha-oxidopregn-4-ene-3,20-dione + NADPH + O2
16alpha-hydroxyandrost-4-ene-3,17-dione
-
degradation of pregnane side chains
-
?
16alpha,17alpha-oxidopregn-4-ene-3,20-dione + NADPH + O2
16alpha-hydroxyandrost-4-ene-3,17-dione
-
degradation of pregnane side chains
-
?
17alpha-hydroxypregn-4-ene-3,20-dione + NADPH + O2
androst-4-ene-3,17-dione + NADP+ + ?
-
degradation of pregnane side chains, about 210% the rate of the reaction with progesterone
-
?
17alpha-hydroxypregn-4-ene-3,20-dione + NADPH + O2
androst-4-ene-3,17-dione + NADP+ + ?
-
degradation of pregnane side chains, about 210% the rate of the reaction with progesterone
-
?
deoxycorticosterone + NADPH + O2
testosterone + NADP+ + ?
-
degradation of pregnane side chains, about 64% the rate of the reaction with progesterone
-
?
deoxycorticosterone + NADPH + O2
testosterone + NADP+ + ?
-
degradation of pregnane side chains, about 64% the rate of the reaction with progesterone
-
?
progesterone + NADPH + H+ + O2
Testosterone acetate + NADP+ + H2O
-
-
-
?
progesterone + NADPH + H+ + O2
Testosterone acetate + NADP+ + H2O
-
-
-
?
progesterone + NADPH + H+ + O2
Testosterone acetate + NADP+ + H2O
-
-
-
?
progesterone + NADPH + H+ + O2
Testosterone acetate + NADP+ + H2O
-
-
-
?
progesterone + NADPH + H+ + O2
Testosterone acetate + NADP+ + H2O
-
-
-
?
progesterone + NADPH + H+ + O2
Testosterone acetate + NADP+ + H2O
-
-
-
?
progesterone + NADPH + H+ + O2
Testosterone acetate + NADP+ + H2O
-
-
-
?
progesterone + NADPH + H+ + O2
Testosterone acetate + NADP+ + H2O
-
-
-
?
progesterone + NADPH + H+ + O2
Testosterone acetate + NADP+ + H2O
-
-
-
?
progesterone + NADPH + H+ + O2
Testosterone acetate + NADP+ + H2O
-
-
-
?
progesterone + NADPH + H+ + O2
Testosterone acetate + NADP+ + H2O
-
-
-
?
progesterone + NADPH + H+ + O2
Testosterone acetate + NADP+ + H2O
-
-
-
?
testosterone + NADPH + O2
6beta-hydroxytestosterone + NADP+ + H2O
-
-
-
?
testosterone + NADPH + O2
6beta-hydroxytestosterone + NADP+ + H2O
-
-
-
?
testosterone + NADPH + O2
6beta-hydroxytestosterone + NADP+ + H2O
-
-
-
?
additional information
?
-
-
cortisol, 20alpha-hydroxy-16alpha,17alpha-oxidopregn-4-ene-3,20-dione and 20beta-hydroxypregn-4-ene-3-one are no substrates
-
-
?
additional information
?
-
-
cortisol, 20alpha-hydroxy-16alpha,17alpha-oxidopregn-4-ene-3,20-dione and 20beta-hydroxypregn-4-ene-3-one are no substrates
-
-
?
