1.14.99.38: cholesterol 25-monooxygenase

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For detailed information about cholesterol 25-monooxygenase, go to the full flat file.

Word Map on EC 1.14.99.38

1.14.99.38

pregnane

cyp2b10

25-hydroxycholesterol

androstane

oxysterols

drug-metabolizing

phenobarbital

cyp2c29

ugt1a1

interferon-stimulated

cyp3a13

apap-induced

lithocholic

acetaminophen-induced

pxr-mediated

cyp2a4

pxr-null

tcpobop

medicine

Reaction

Synonyms

CH25A, CH25H, cholesterol 25-hydroxylase, cholesterol 25-monooxygenase, cholesterol-25-hydroxylase, CYP1A2, CYP27A1, CYP2C9, CYP2D6, CYP3A, Cyp3a11, CYP3A4

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.99 Miscellaneous

1.14.99.38 cholesterol 25-monooxygenase

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Results	in table
4	Activating Compound
21	AA Sequence
2	Application
1	CAS Registry Number
19	Cloned(Commentary)
297	Disease/ Diagnostics
14	Expression
27	General Information
4	Inhibitors
24	Localization
13	Metals/Ions
12	Molecular Weight [Da]
41	Natural Substrates/ Products (Substrates)
43	Organism
1	Pathway
5	PDB ID
9	pI Value
4	Protein Variants
1	Reaction
9	Reaction Type
39	Reference
78	Source Tissue
48	Substrates and Products (Substrate)
12	Subunits
52	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 1.14.99.38 - cholesterol 25-monooxygenase

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cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating)

Unlike most other sterol hydroxylases, this enzyme is not a cytochrome P-450. Instead, it uses diiron cofactors to catalyse the hydroxylation of hydrophobic substrates [1]. The diiron cofactor can be either Fe-O-Fe or Fe-OH-Fe and is bound to the enzyme through interactions with clustered histidine or glutamate residues [4,5]. In cell cultures, this enzyme down-regulates cholesterol synthesis and the processing of sterol regulatory element binding proteins (SREBPs). cf. EC 1.17.99.10, cholesterol C-25 hydroxylase.