1.14.99.29: deoxyhypusine monooxygenase
This is an abbreviated version!
For detailed information about deoxyhypusine monooxygenase, go to the full flat file.
Word Map on EC 1.14.99.29
-
1.14.99.29
-
eif-5a
-
spermidine
-
hypusine-containing
-
gc7
-
mimosine
-
ciclopirox
-
nepsilon-4-amino-2-hydroxybutyllysine
-
drug development
-
deferiprone
-
eif5a-1
-
polyamine-derived
-
4-aminobutyl
-
diiron
-
n1-guanyl-1,7-diaminoheptane
-
heat-repeats
-
heat-like
-
peroxo
-
deoxyhypusine-containing
-
medicine
- 1.14.99.29
-
eif-5a
- spermidine
-
hypusine-containing
- gc7
- mimosine
- ciclopirox
-
nepsilon-4-amino-2-hydroxybutyllysine
- drug development
- deferiprone
-
eif5a-1
-
polyamine-derived
-
4-aminobutyl
-
diiron
- n1-guanyl-1,7-diaminoheptane
-
heat-repeats
-
heat-like
-
peroxo
-
deoxyhypusine-containing
- medicine
Reaction
Synonyms
deoxyhypusine hydroxylase, deoxyhypusine hydroxylase homologue nero, deoxyhypusine synthase/hydroxylase, deoxyhypusyl hydroxylase, DOHH, DOOH, hDOHH, Lia1, More, nero, oxygenase, deoxyhypusine di-
ECTree
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Reference on EC 1.14.99.29 - deoxyhypusine monooxygenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Abbruzzese, A.; Park, M.H.; Folk J.E.
Deoxyhypusine hydroxylase from rat testis. Partial purification and characterization
J. Biol. Chem.
261
3085-3089
1986
Rattus norvegicus
Park, M.H.; Cooper, H.L.; Folk, J.E.
The biosynthesis of protein-bound hypusine (N epsilon-(4-amino-2-hydroxybutyl)lysine). Lysine as the amino acid precursor and the intermediate role of deoxyhypusine (N epsilon-(4-aminobutyl)lysine)
J. Biol. Chem.
257
7217-7222
1982
Cricetulus griseus
Clement, P.M.J.; Hanauske-Abel, H.M.; Wolff, E.C.; Kleinman, H.K.; Park, M.H.
The antifungal drug ciclopirox inhibits deoxyhypusine and proline hydroxylation, endothelial cell growth and angiogenesis in vitro
Int. J. Cancer
100
491-498
2002
Homo sapiens
Beninati, S.; Ferraro, G.; Abbruzzese, A.
Catalytic properties of deoxyhypusine hydroxylase
Ital. J. Biochem.
39
183A-185A
1990
Rattus norvegicus
Hanauske-Abel, H.M.; Park, M.H.; Hanauske, A.R.; Popowicz, A.M.; Lalande, M.; Folk, J.E.
Inhibition of the G1-S transition of the cell cycle by inhibitors of deoxyhypusine hydroxylation
Biochim. Biophys. Acta
1221
115-124
1994
Cricetulus griseus, Homo sapiens
Csonga, R.; Ettmayer, P.; Auer, M.; Eckerskorn, C.; Eder, J.; Klier, H.
Evaluation of the metal ion requirement of the human deoxyhypusine hydroxylase from HeLa cells using a novel enzyme assay
FEBS Lett.
380
209-214
1996
Homo sapiens
Abbruzzese, A.; Hanauske-Abel, H.M.; Park, M.H.; Henke, S.; Folk, J.E.
The active site of deoxyhypusyl hydroxylase: use of catecholpeptides and their component chelator and peptide moieties as molecular probes
Biochim. Biophys. Acta
1077
159-166
1991
Rattus norvegicus
Andrus, L.; Szabo, P.; Grady, R.W.; Hanauske, A.R.; Huima-Byron, T.; Slowinska, B.; Zagulska, S.; Hanauske-Abel, H.M.
Antiretroviral effects of deoxyhypusyl hydroxylase inhibitors. A hypusine-dependent host cell mechanism for replication of human immunodeficiency virus type 1 (HIV-1)
Biochem. Pharmacol.
55
1807-1818
1998
Homo sapiens
Abbruzzese, A.; Park, M.H.; Beninati, S.; Folk, J.E.
Inhibition of deoxyhypusine hydroxylase by polyamines and by a deoxyhypusine peptide
Biochim. Biophys. Acta
997
248-255
1989
Cricetulus griseus, Rattus norvegicus
Abbruzzese, A.; Liguori, V.; Park, M.H.
Deoxyhypusine hydroxylase
Adv. Exp. Med. Biol.
250
459-466
1988
Rattus norvegicus
Kim, Y.S.; Kang, K.R.; Wolff, E.C.; Bell, J.K.; McPhie, P.; Park, M.H.
Deoxyhypusine hydroxylase is an Fe(II)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis
J. Biol. Chem.
281
13217-13225
2006
Homo sapiens
Kang, K.R.; Kim, Y.S.; Wolff, E.C.; Park, M.H.
Specificity of the deoxyhypusine hydroxylase-eukaryotic translation initiation factor (eIF5A) interaction: identification of amino acid residues of the enzyme required for binding of its substrate, deoxyhypusine-containing eIF5A
J. Biol. Chem.
282
8300-8308
2007
Homo sapiens
Dong, Z.; Arnold, R.J.; Yang, Y.; Park, M.H.; Hrncirova, P.; Mechref, Y.; Novotny, M.V.; Zhang, J.T.
Modulation of differentiation-related gene 1 expression by cell cycle blocker mimosine, revealed by proteomic analysis
Mol. Cell. Proteomics
4
993-1001
2005
Homo sapiens
Park, J.H.; Aravind, L.; Wolff, E.C.; Kaevel, J.; Kim, Y.S.; Park, M.H.
Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme
Proc. Natl. Acad. Sci. USA
103
51-56
2006
Homo sapiens, Saccharomyces cerevisiae
Cano, V.S.; Jeon, G.A.; Johansson, H.E.; Henderson, C.A.; Park, J.H.; Valentini, S.R.; Hershey, J.W.; Park, M.H.
Mutational analyses of human eIF5A-1--identification of amino acid residues critical for eIF5A activity and hypusine modification
FEBS J.
275
44-58
2008
Saccharomyces cerevisiae, Homo sapiens
Huang, J.K.; Cui, Y.; Chen, C.H.; Clampitt, D.; Lin, C.T.; Wen, L.
Molecular cloning and functional expression of bovine deoxyhypusine hydroxylase cDNA and homologs
Protein Expr. Purif.
54
126-133
2007
Bos taurus (Q0VC53), Bos taurus
Frommholz, D.; Kusch, P.; Blavid, R.; Scheer, H.; Tu, J.M.; Marcus, K.; Zhao, K.H.; Atemnkeng, V.; Marciniak, J.; Kaiser, A.E.
Completing the hypusine pathway in Plasmodium
FEBS J.
276
5881-5891
2009
Plasmodium falciparum (C9QNK6), Plasmodium falciparum
Patel, P.H.; Costa-Mattioli, M.; Schulze, K.L.; Bellen, H.J.
The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy
J. Cell Biol.
185
1181-1194
2009
Drosophila melanogaster
Vu, V.V.; Emerson, J.P.; Martinho, M.; Kim, Y.S.; Muenck, E.; Park, M.H.; Que, L.
Human deoxyhypusine hydroxylase, an enzyme involved in regulating cell growth, activates O2 with a nonheme diiron center
Proc. Natl. Acad. Sci. USA
106
14814-14819
2009
Homo sapiens
Hoque, M.; Hanauske-Abel, H.M.; Palumbo, P.; Saxena, D.; DAlliessi Gandolfi, D.; Park, M.H.; Peery, T.; Mathews, M.B.
Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A
Retrovirology
6
90
2009
Homo sapiens
Park, M.H.; Nishimura, K.; Zanelli, C.F.; Valentini, S.R.
Functional significance of eIF5A and its hypusine modification in eukaryotes
Amino Acids
38
491-500
2010
Bos taurus, Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Schizosaccharomyces pombe
Kerscher, B.; Nzukou, E.; Kaiser, A.
Assessment of deoxyhypusine hydroxylase as a putative, novel drug target
Amino Acids
38
471-477
2010
Bos taurus, Saccharomyces cerevisiae, Drosophila melanogaster, Homo sapiens, Plasmodium falciparum, Rattus norvegicus, Schizosaccharomyces pombe
Cano, V.; Medrano, F.; Park, M.; Valentini, S.
Evidence for conformational changes in the yeast deoxyhypusine hydroxylase Lia1 upon iron displacement from its active site
Amino Acids
38
479-490
2010
Saccharomyces cerevisiae
Lee, N.; Tsang, F.; Shek, F.; Mao, M.; Dai, H.; Zhang, C.; Dong, S.; Guan, X.; Poon, R.; Luk, J.
Prognostic significance and therapeutic potential of eukaryotic translation initiation factor 5A (eIF5A) in hepatocellular carcinoma
Int. J. Cancer
127
968-976
2010
Homo sapiens
Park, J.; Dias, C.; Lee, S.; Valentini, S.; Sokabe, M.; Fraser, C.; Park, M.
Production of active recombinant eIF5A: Reconstitution in E. coli of eukaryotic hypusine modification of eIF5A by its coexpression with modifying enzymes
Protein Eng. Des. Sel.
24
301-309
2011
Homo sapiens
Epis, M.R.; Giles, K.M.; Kalinowski, F.C.; Barker, A.; Cohen, R.J.; Leedman, P.J.
Regulation of expression of deoxyhypusine hydroxylase (DOHH), the enzyme that catalyzes the activation of eIF5A, by miR-331-3p and miR-642-5p in prostate cancer cells
J. Biol. Chem.
287
35251-35259
2012
Homo sapiens (Q9BU89), Homo sapiens
Atemnkeng, V.A.; Pink, M.; Schmitz-Spanke, S.; Wu, X.J.; Dong, L.L.; Zhao, K.H.; May, C.; Laufer, S.; Langer, B.; Kaiser, A.
Deoxyhypusine hydroxylase from Plasmodium vivax, the neglected human malaria parasite: molecular cloning, expression and specific inhibition by the 5-LOX inhibitor zileuton
PLoS ONE
8
e58318
2013
Plasmodium vivax (A5JZ19), Plasmodium vivax, Plasmodium vivax Salvador I (A5JZ19)
von Koschitzky, I.; Gerhardt, H.; Laemmerhofer, M.; Kohout, M.; Gehringer, M.; Laufer, S.; Pink, M.; Schmitz-Spanke, S.; Strube, C.; Kaiser, A.
New insights into novel inhibitors against deoxyhypusine hydroxylase from Plasmodium falciparum compounds with an iron chelating potential
Amino Acids
47
1155-1166
2015
Plasmodium falciparum
Caceres, C.J.; Angulo, J.; Contreras, N.; Pino, K.; Vera-Otarola, J.; Lopez-Lastra, M.
Targeting deoxyhypusine hydroxylase activity impairs cap-independent translation initiation driven by the 5'untranslated region of the HIV-1, HTLV-1, and MMTV mRNAs
Antiviral Res.
134
192-206
2016
Homo sapiens (Q9BU89)
Quintas-Granados, L.I.; Carvajal Gamez, B.I.; Villalpando, J.L.; Ortega-Lopez, J.; Arroyo, R.; Azuara-Liceaga, E.; Alvarez-Sanchez, M.E.
Bifunctional activity of deoxyhypusine synthase/hydroxylase from Trichomonas vaginalis
Biochimie
123
37-51
2016
Trichomonas vaginalis
Belda-Palazon, B.; Nohales, M.A.; Rambla, J.L.; Acena, J.L.; Delgado, O.; Fustero, S.; Martinez, M.C.; Granell, A.; Carbonell, J.; Ferrando, A.
Biochemical quantitation of the eIF5A hypusination in Arabidopsis thaliana uncovers ABA-dependent regulation
Front. Plant Sci.
5
202
2014
Arabidopsis thaliana (Q8I701), Arabidopsis thaliana
Jasniewski, A.J.; Engstrom, L.M.; Vu, V.V.; Park, M.H.; Que, L.
X-ray absorption spectroscopic characterization of the diferric-peroxo intermediate of human deoxyhypusine hydroxylase in the presence of its substrate eIF5a
J. Biol. Inorg. Chem.
21
605-618
2016
Homo sapiens (Q9BU89), Homo sapiens
Frey, A.G.; Nandal, A.; Park, J.H.; Smith, P.M.; Yabe, T.; Ryu, M.S.; Ghosh, M.C.; Lee, J.; Rouault, T.A.; Park, M.H.; Philpott, C.C.
Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase
Proc. Natl. Acad. Sci. USA
111
8031-8036
2014
Homo sapiens (Q9BU89)
Martinez-Rocha, A.L.; Woriedh, M.; Chemnitz, J.; Willingmann, P.; Kroeger, C.; Hadeler, B.; Hauber, J.; Schaefer, W.
Posttranslational hypusination of the eukaryotic translation initiation factor-5A regulates Fusarium graminearum virulence
Sci. Rep.
6
24698
2016
Fusarium graminearum (Q8I701), Fusarium graminearum
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