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1.14.99.29: deoxyhypusine monooxygenase

This is an abbreviated version!
For detailed information about deoxyhypusine monooxygenase, go to the full flat file.

Word Map on EC 1.14.99.29

Reaction

[eIF5A]-deoxyhypusine
+
reduced acceptor
+
O2
=
[eIF5A]-hypusine
+
acceptor
+
H2O

Synonyms

deoxyhypusine hydroxylase, deoxyhypusine hydroxylase homologue nero, deoxyhypusine synthase/hydroxylase, deoxyhypusyl hydroxylase, DOHH, DOOH, hDOHH, Lia1, More, nero, oxygenase, deoxyhypusine di-

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.99 Miscellaneous
                1.14.99.29 deoxyhypusine monooxygenase

IC50 Value

IC50 Value on EC 1.14.99.29 - deoxyhypusine monooxygenase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.026 - 0.029
2,2'-dipyridyl
0.0007
4,6-diphenyl-1-hydroxy-pyridine-2-one
Homo sapiens
-
IC50 0.0007 mM
0.0006 - 0.005
ciclopirox
0.117
deferiprone
Homo sapiens
-
IC50 0.117 mM
0.016
desferrioxamine B
Homo sapiens
-
IC50 0.016 mM
0.0003
EDTA
Homo sapiens
-
IC50 0.0003 mM
0.5
ethyl 3,4-dihydroxybenzoate
Rattus norvegicus
-
IC50 0.5 mM
1.6
methyl 2,3-dihydroxybenzoate
Rattus norvegicus
-
IC50 1.6 mM
0.0028
metipirox
Homo sapiens
-
IC50 0.0028 mM
0.0033 - 0.191
mimosine
0.2
N1-acetyl-N4-(2,3-dihydroxybenzoyl)-L-Orn-L-Pro-Gly
Rattus norvegicus
-
IC50 0.2 mM
0.03
N1-acetyl-N4-(3,4-dihydroxybenzoyl)-L-Orn-L-Pro-Gly
Rattus norvegicus
-
IC50 0.03 mM
0.0000125
zileuton
Plasmodium vivax
recombinant His-tagged enzyme, pH 7.5, 37°C