1.14.99.29: deoxyhypusine monooxygenase

This is an abbreviated version!
For detailed information about deoxyhypusine monooxygenase, go to the full flat file.

Word Map on EC 1.14.99.29

1.14.99.29

eif-5a

spermidine

hypusine-containing

gc7

mimosine

ciclopirox

nepsilon-4-amino-2-hydroxybutyllysine

drug development

deferiprone

eif5a-1

polyamine-derived

4-aminobutyl

diiron

n1-guanyl-1,7-diaminoheptane

heat-repeats

heat-like

peroxo

deoxyhypusine-containing

medicine

Reaction

Synonyms

deoxyhypusine hydroxylase, deoxyhypusine hydroxylase homologue nero, deoxyhypusine synthase/hydroxylase, deoxyhypusyl hydroxylase, DOHH, DOOH, hDOHH, Lia1, More, nero, oxygenase, deoxyhypusine di-

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.99 Miscellaneous

1.14.99.29 deoxyhypusine monooxygenase

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Results	in table
3	Activating Compound
2952	AA Sequence
10	Application
2	CAS Registry Number
22	Cloned(Commentary)
2	Cofactor
1	Crystallization (Commentary)
19	Disease/ Diagnostics
1	Expression
50	General Information
3	General Stability
16	IC50 Value
103	Inhibitors
3	Ki Value [mM]
4	KM Value [mM]
2	Localization
25	Metals/Ions
10	Molecular Weight [Da]
37	Natural Substrates/ Products (Substrates)
51	Organism
1	Pathway
4	PDB ID
12	pH Optimum
3	pI Value
56	Protein Variants
16	Purification (Commentary)
2	Reaction
21	Reaction Type
51	Reference
1	Renatured (Commentary)
36	Source Tissue
6	Specific Activity [micromol/min/mg]
1	Storage Stability
67	Substrates and Products (Substrate)
21	Subunits
80	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]

Disease

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Disease on EC 1.14.99.29 - deoxyhypusine monooxygenase

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Adenocarcinoma

A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer.

25261239

Glioblastoma

Expression of Eukaryotic Initiation Factor 5A and Hypusine Forming Enzymes in Glioblastoma Patient Samples: Implications for New Targeted Therapies.

22927971

Leishmaniasis

Targeting polyamine metabolism for finding new drugs against leishmaniasis: a review.

25769972

Malaria

A suggested vital function for eIF-5A and dhs genes during murine malaria blood-stage infection.

27516964

Chemical profiling of deoxyhypusine hydroxylase inhibitors for antimalarial therapy.

23943044

Deoxyhypusine Hydroxylase from Plasmodium vivax, the Neglected Human Malaria Parasite: Molecular Cloning, Expression and Specific Inhibition by the 5-LOX Inhibitor Zileuton.

23505486

Neoplasms

Blocking eIF5A modification in cervical cancer cells alters the expression of cancer-related genes and suppresses cell proliferation.

24220243

The polyamine-derived amino acid hypusine: its post-translational formation in eIF-5A and its role in cell proliferation.

24178473

Prostatic Neoplasms

Regulation of expression of deoxyhypusine hydroxylase (DOHH), the enzyme that catalyzes the activation of eIF5A, by miR-331-3p and miR-642-5p in prostate cancer cells.

22908221