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1.14.99.15: 4-methoxybenzoate monooxygenase (O-demethylating)

This is an abbreviated version!
For detailed information about 4-methoxybenzoate monooxygenase (O-demethylating), go to the full flat file.

Word Map on EC 1.14.99.15

Reaction

4-Methoxybenzoate
+
reduced acceptor
+
O2
=
4-hydroxybenzoate
+
formaldehyde
+
acceptor
+
H2O

Synonyms

4-methoxybenzoate 4-monooxygenase (O-demethylating), 4-methoxybenzoate monooxygenase, 4-methoxybenzoate O-demethylase, CYP199A2, CYP199A4, cytochrome P450 199A2, oxygenase, 4-methoxybenzoate 4-mono- (O-demethylating), p-anisic O-demethylase, piperonylate-4-O-demethylase, RPA1871

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.99 Miscellaneous
                1.14.99.15 4-methoxybenzoate monooxygenase (O-demethylating)

Inhibitors

Inhibitors on EC 1.14.99.15 - 4-methoxybenzoate monooxygenase (O-demethylating)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
-
2,2'-dipyridyl
-
-
3-Methoxybenzoate
-
-
4-(2-Pyridylazo)resorcinol
-
-
4-tert-Butylbenzoate
-
competitive inhibitor of the O-demethylation of 3-nitro-4-methoxybenzoate, hinders O2-binding or O2-activation
4-trifluoromethylbenzoate
-
-
5,5'-dithiobis(2-nitrobenzoate)
-
-
8-hydroxyquinoline
-
-
Bathocuproinedisulfonate
-
-
bathophenanthrolinedisulfate
benzoate
-
competitive inhibition
Cl-
addition of chloride to the phosphate buffered samples weakens substrate binding, chloride binding site structure, overview; addition of chloride to the phosphate buffered samples weakens substrate binding, chloride binding site structure, overview
Cumylhydroperoxide
-
-
diethyldithiocarbamate
-
-
Iodosobenzene
-
-
Oxidized putidamonooxin
-
60% inhibition with 3-nitro-4-methoxybenzoate as substrate, fully reactivated by Fe2+ and sulfhydryl-reagents
-
p-chloromercuribenzoate
Thenoyl trifluoroacetone
-
-