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1.14.99.1: prostaglandin-endoperoxide synthase

This is an abbreviated version!
For detailed information about prostaglandin-endoperoxide synthase, go to the full flat file.

Word Map on EC 1.14.99.1

Reaction

arachidonate
+
reduced acceptor
 + 2 O2 =
prostaglandin H2
 +
acceptor
 +
H2O

Synonyms

(PG)H synthase, COX, COX-1, COX-2, COX1, Cox2, cyclooxygenase, cyclooxygenase 1, cyclooxygenase 2, cyclooxygenase-1, cyclooxygenase-1b, cyclooxygenase-2, cycloxigenase-2, fatty acid cyclooxygenase, hPGHS-1, hPGHS-2, oPGHS-1, PG G/H synthase 2, PG H synthase, PG synthetase, PG-endoperoxide synthase 2, PG-endoperoxide synthetase, PGH-synthase, PGHS, PGHS isoform-1, PGHS-1, PGHS-2, PHS, PHS-1, PHS-2, prostagladin-H synthase, prostaglandin endoperoxide H synthase, prostaglandin endoperoxide H synthase 1, prostaglandin endoperoxide H synthase 2, prostaglandin endoperoxide H synthase-1, prostaglandin endoperoxide H2 synthase-2, prostaglandin endoperoxide synthase, prostaglandin endoperoxide synthase 2, prostaglandin endoperoxide synthase-1, prostaglandin endoperoxide synthase-2, prostaglandin endoperoxide synthetase, prostaglandin G/H synthase, prostaglandin G/H synthase-2, prostaglandin H synthase, prostaglandin H synthase-1, prostaglandin H synthase-2, prostaglandin H2 synthase, prostaglandin H2 synthase-1, prostaglandin synthase, prostaglandin synthase-2, prostaglandin synthetase, prostaglandin-endoperoxide synthase, prostaglandin-endoperoxide synthase 1, prostaglandin-endoperoxide synthase 2, prostaglandin-H-synthase, prostaglandin-H-synthase 1, prostaglandin-H-synthase 2, PTGS 2, PTGS-1, PTGS-2, PTGS1, PTGS2, putative cyclooxygenase-3, synthase, prostaglandin, tPGHS-1, tPGHS-2

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.99 Miscellaneous
                1.14.99.1 prostaglandin-endoperoxide synthase

Reference

topprint

Reference on EC 1.14.99.1 - prostaglandin-endoperoxide synthase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
DeWitt, D.L.; Smith, W.L.
Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence [published erratum appears in Proc Natl Acad Sci U S A 1988 Jul;85(14):5056]
Proc. Natl. Acad. Sci. USA
85
1412-1416
1988
Ovis aries
Manually annotated by BRENDA team
Saeed, S.A.; Butt, N.M.; McDonald-Gibson, W.J.
The effect of ellagic acid and tannic acid on prostaglandin synthase activity in bovine seminal-vesicle homogenates
Biochem. Soc. Trans.
8
443
1981
Bos taurus
-
Manually annotated by BRENDA team
Narayanan, R.; Harrington, M.G.
Hydroperoxyeicosatetraenoic acid: an activator of prostaglandin synthase activity
Biochem. Soc. Trans.
8
449-450
1980
Ovis aries
Manually annotated by BRENDA team
Denning-Kendall, P.A.; Saeed, S.A.
Effect of cofactor, enzyme and substrate concentration on inhibition of prostaglandin synthase of bull seminal vesicles by human serum, haptoglobin and albumin
Biochem. Soc. Trans.
9
379-380
1981
Bos taurus
-
Manually annotated by BRENDA team
Ryan, J.; Davis, G.
Inhibition of prostaglandin synthase by some low molecular mass fatty acids
Biochem. Soc. Trans.
16
398-399
1988
Rattus norvegicus
-
Manually annotated by BRENDA team
Hemler, M.; Lands, W.E.M.
Purification of the cyclooxygenase that forms prostaglandins. Demonstration of two forms of iron in the holoenzyme
J. Biol. Chem.
251
5575-5579
1976
Ovis aries
Manually annotated by BRENDA team
Miyamoto, T.; Ogino, N.; Yamamoto, S.; Hayaishi, O.
Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes
J. Biol. Chem.
251
2629-2636
1976
Bos taurus
Manually annotated by BRENDA team
Marnett, L.J.; Dix, T.A.; Sachs, R.J.; Siedlik, P.H.
Oxidations by fatty acid hydroperoxides and prostaglandin synthase
Adv. Prostaglandin Thromboxane Leukot. Res.
11
79-86
1983
Ovis aries
Manually annotated by BRENDA team
Zenser, T.V.; Mattammal, M.B.; Armbrecht, H.J.; Davis, B.B.
Benzidine binding to nucleic acids mediated by the peroxidative activity of prostaglandin endoperoxide synthetase
Cancer Res.
40
2839-2845
1980
Oryctolagus cuniculus
Manually annotated by BRENDA team
Egan, R.W.; Gale, P.O.H.; Baptista, E.M.; Kennicott, K.L.; VandenHeuvel, W.J.A.; Walker, R.W.; Fagerness, P.W.; Kuehl, F.A.
Oxidation reactions by prostaglandin cyclooxygenase-hydroperoxidase
J. Biol. Chem.
256
7352-7361
1981
Ovis aries
Manually annotated by BRENDA team
Van der Ouderaa, F.J.; Buytenhek, M.; Nugteren, D.H.; Van Dorp, D.A.
Acetylation of prostaglandin endoperoxide synthetase with acetylsalicylic acid
Eur. J. Biochem.
109
1-8
1980
Ovis aries
Manually annotated by BRENDA team
Mizuno, K.; Yamamoto, S.; Lands, W.E.M.
Effects of non-steroidal anti-inflammatory drugs on fatty acid cyclooxygenase and prostaglandin hydroperoxidase activities
Prostaglandins
23
743-757
1982
Bos taurus
Manually annotated by BRENDA team
DeWitt, D.L.; Rollins, T.E.; Day, J.S.; Gauger, J.A.; Smith, W.L.
Orientation of the active site and antigenic determinants of prostaglandin endoperoxide synthase in the endoplasmic reticulum
J. Biol. Chem.
256
10375-10382
1981
Ovis aries
Manually annotated by BRENDA team
Smith, W.L.
Prostaglandin biosynthesis and its compartmentation in vascular smooth muscle and endothelial cells
Annu. Rev. Physiol.
48
251-262
1986
Bos taurus, Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Roth, G.J.; Siok, C.J.; Ozols, J.
Structural characteristics of prostaglandin synthetase from sheep vesicular gland
J. Biol. Chem.
255
1301-1304
1980
Ovis aries
Manually annotated by BRENDA team
Marnett, L.J.; Chen, Y.N.P.; Maddipati, K.R.; Ple, P.; Labeque, R.
Functional differentiation of cyclooxygenase and peroxidase activities of prostaglandin synthase by trypsin treatment. Possible location of a prosthetic heme binding site
J. Biol. Chem.
263
16532-16535
1988
Ovis aries
Manually annotated by BRENDA team
Marnett, L.J.; Siedlick, P.H.; Ochs, R.C.; Pagels, W.R.; Das, M.; Honn, K.V.; Warnock, R.H.; Tainer, B.E.; Eling, T.E.
Mechanism of the stimulation of prostaglandin H synthase and prostacyclin synthase by the antithrombotic and antimetastatic agent, nafazatrom
Mol. Pharmacol.
26
328-335
1984
Ovis aries
Manually annotated by BRENDA team
Ohki, S.; Ogino, N.; Yamamoto, S.; Hayaishi, O.; Yamamoto, H.; Miyake, H.; Hayashi, M.
Inhibition of prostaglandin endoperoxide synthetase by thiol analogues of prostaglandin
Proc. Natl. Acad. Sci. USA
74
144-148
1977
Bos taurus
Manually annotated by BRENDA team
Wlodawer, P.; Samuelsson, B.
On the organization and mechanism of prostaglandin synthetase
J. Biol. Chem.
248
5673-5678
1973
Ovis aries
Manually annotated by BRENDA team
Golly, I.; Hlavica, P.
N-Oxidation of 4-chloroaniline by prostaglandin synthase
Biochem. J.
260
803-809
1985
Ovis aries
Manually annotated by BRENDA team
Tai, H.H.; Tai, C.L.; Hollander, C.S.
Biosynthesis of prostaglandins in rabbit kidney medulla. Properties of prostaglandin synthase
Biochem. J.
154
257-264
1976
Oryctolagus cuniculus
Manually annotated by BRENDA team
Friedman, Y.; Lang, M.; Burke, G.
Further characterization of bovine thyroid prostaglandin synthase
Biochim. Biophys. Acta
397
331-341
1975
Bos taurus
Manually annotated by BRENDA team
Parkes, D.G.; Eling, T.E.
Characterization of prostaglandin synthetase in guinea pig lung. Isolation of a new prostaglandin derivative from arachidonic acid
Biochemistry
13
2598-2604
1974
Cavia porcellus
Manually annotated by BRENDA team
Pace-Asciak, C.
Prostaglandin synthetase activity in the rat stomach fundus. Activation by L-norepinephrine and related compounds
Biochim. Biophys. Acta
280
161-171
1972
Rattus norvegicus
Manually annotated by BRENDA team
Miller, D.B.; Munster, D.; Wasvary, J.S.; Simke, J.P.; Peppard, J.V.; Bowen, B.R.; Marshall, P.J.
The heterologous expression and characterization of human prostaglandin G/H synthase-2 (COX-2)
Biochem. Biophys. Res. Commun.
201
356-362
1994
Homo sapiens
Manually annotated by BRENDA team
Liu, J.; Antaya, M.; Goff, A.K.; Boerboom, D.; Silversides, D.W.; Lussier, J.G.; Sirois, J.
Molecular characterization of bovine prostaglandin G/H synthase-2 and regulation in uterine stromal cells
Biol. Reprod.
64
983-991
2001
Bos taurus (O62698), Bos taurus
Manually annotated by BRENDA team
Doualla-Bell, F.; Guay, J.M.; Bourgoin, S.; Fortier, M.A.
Prostaglandin G/H synthase (PGHS)-2 expression in bovine myometrium: influence of steroid hormones and PGHS inhibitors
Biol. Reprod.
59
1433-1438
1998
Bos taurus
Manually annotated by BRENDA team
Kargman, S.; Wong, E.; Greig, G.M.; Falgueyret, J.P.; Cromlish, W.; Ethier, D.; Yergey, J.A.; Riendeau, D.; Evans, J.F.; Kennedy, B.; Tagari, P.; Francis, D.A.; O'Neill, G.P.
Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells
Biochem. Pharmacol.
52
1113-1125
1996
Homo sapiens
Manually annotated by BRENDA team
Forghani, F.; Ouellet, M.; Keen, S.; Percival, M.D.; Tagari, P.
Analysis of prostaglandin G/H synthase-2 inhibition using peroxidase-induced luminol luminescence
Anal. Biochem.
264
216-221
1998
Homo sapiens
Manually annotated by BRENDA team
Mancini, J.A.; Vickers, P.J.; O'Neill, G.P.; Boily, C.; Falgueyret, J.P.; Riendeau, D.
Altered sensitivity of aspirin-acetylated prostaglandin G/H synthase-2 to inhibition by nonsteroidal anti-inflammatory drugs
Mol. Pharmacol.
51
52-60
1997
Homo sapiens
Manually annotated by BRENDA team
George, H.J.; Van Dyk, D.E.; Straney, R.A.; Trzaskos, J.M.; Copeland, R.A.
Expression purification and characterization of recombinant human inducible prostaglandin G/H synthase from baculovirus-infected insect cells
Protein Expr. Purif.
7
19-26
1996
Homo sapiens
Manually annotated by BRENDA team
Smith, C.J.; Marnett, L.J.
Effects of cysteine-to-serine mutations on structural and functional properties of prostaglandin endoperoxide synthase
Arch. Biochem. Biophys.
335
342-350
1996
Ovis aries
Manually annotated by BRENDA team
Ishii, R.; Horie, M.; Saito, K.; Arisawa, M.; Kitanaka, S.
Prostaglandin E(2) production and induction of prostaglandin endoperoxide synthase-2 is inhibited in a murine macrophage-like cell line, RAW 264.7, by Mallotus japonicus phloroglucinol derivatives
Biochim. Biophys. Acta
1571
115-123
2002
Mus musculus
Manually annotated by BRENDA team
Barnett, J.; Chow, J.; Ives, D.; Chiou, M.; Mackenzie, R.; Osen, E.; Nguyen, B.; Tsing, S.; Bach, C.; Freire, J.; et al.
Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system
Biochim. Biophys. Acta
1209
130-139
1994
Homo sapiens
Manually annotated by BRENDA team
Kargman, S.; Charleson, S.; Cartwright, M.; Frank, J.; Riendeau, D.; Mancini, J.; Evans, J.; O'Neill, G.
Characterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts
Gastroenterology
111
445-454
1996
Canis lupus familiaris, Homo sapiens, Macaca mulatta, Rattus norvegicus, Saimiri sciureus
Manually annotated by BRENDA team
Boutemmine, D.; Bouchard, N.; Boerboom, D.; Jones, H.E.; Goff, A.K.; Dore, M.; Sirois, J.
Molecular characterization of canine prostaglandin G/H synthase-2 and regulation in prostatic adenocarcinoma cells in vitro
Endocrinology
143
1134-1143
2002
Canis lupus familiaris
Manually annotated by BRENDA team
Patrignani, P.; Panara, M.R.; Sciulli, M.G.; Santini, G.; Renda, G.; Patrono, C.
Differential inhibition of human prostaglandin endoperoxide synthase-1 and -2 by nonsteroidal anti-inflammatory drugs
J. Physiol. Pharmacol.
48
623-631
1997
Homo sapiens
Manually annotated by BRENDA team
Chulada, P.C.; Loftin, C.D.; Winn, V.D.; Young, D.A.; Tiano, H.F.; Eling, T.E.; Langenbach, R.
Relative activities of retrovirally expressed murine prostaglandin synthase-1 and -2 depend on source of arachidonic acid
Arch. Biochem. Biophys.
330
301-313
1996
Mus musculus
Manually annotated by BRENDA team
Mancini, J.A.; Riendeau, D.; Falgueyret, J.P.; Vickers, P.J.; O'Neill, G.P.
Arginine 120 of prostaglandin G/H synthase-1 is required for the inhibition by nonsteroidal anti-inflammatory drugs containing a carboxylic acid moiety
J. Biol. Chem.
270
29372-29377
1995
Ovis aries
Manually annotated by BRENDA team
Meade, E.A.; Smith, W.L.; DeWitt, D.L.
Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs
J. Biol. Chem.
268
6610-6614
1993
Mus musculus
Manually annotated by BRENDA team
O'Neill, G.P.; Mancini, J.A.; Kargman, S.; Yergey, J.; Kwan, M.Y.; Falgueyret, J.P.; Abramovitz, M.; Kennedy, B.P.; Ouellet, M.; Cromlish, W.
Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid
Mol. Pharmacol.
45
245-254
1994
Homo sapiens
Manually annotated by BRENDA team
Roberts, S.B.; Langenau, D.M.; Goetz, F.W.
Cloning and characterization of prostaglandin endoperoxide synthase-1 and -2 from the brook trout ovary
Mol. Cell. Endocrinol.
160
89-97
2000
Salvelinus fontinalis
Manually annotated by BRENDA team
Rogge, C.E.; Liu, W.; Wu, G.; Wang, L.H.; Kulmacz, R.J.; Tsai, A.L.
Identification of Tyr504 as an alternative tyrosyl radical site in human prostaglandin H synthase-2
Biochemistry
43
1560-1568
2004
Homo sapiens
Manually annotated by BRENDA team
Narayansingh, R.M.; Senchyna, M.; Vijayan, M.M.; Carlson, J.C.
Expression of prostaglandin G/H synthase (PGHS) and heat shock protein-70 (HSP-70) in the corpus luteum (CL) of prostaglandin F2 alpha-treated immature superovulated rats
Can. J. Physiol. Pharmacol.
82
363-371
2004
Rattus norvegicus
Manually annotated by BRENDA team
Bambai, B.; Rogge, C.E.; Stec, B.; Kulmacz, R.J.
Role of Asn-382 and Thr-383 in activation and inactivation of human prostaglandin H synthase cyclooxygenase catalysis
J. Biol. Chem.
279
4084-4092
2004
Homo sapiens
Manually annotated by BRENDA team
Sayasith, K.; Bouchard, N.; Sawadogo, M.; Lussier, J.G.; Sirois, J.
Molecular characterization and role of bovine upstream stimulatory factor 1 and 2 in the regulation of the prostaglandin G/H synthase-2 promoter in granulosa cells
J. Biol. Chem.
279
6327-6336
2004
Bos taurus
Manually annotated by BRENDA team
Gupta, K.; Selinsky, B.S.; Kaub, C.J.; Katz, A.K.; Loll, P.J.
The 2.0 A resolution crystal structure of prostaglandin H2 synthase-1: structural insights into an unusual peroxidase
J. Mol. Biol.
335
503-518
2003
Ovis aries
Manually annotated by BRENDA team
Snipes, J.A.; Kis, B.; Shelness, G.S.; Hewett, J.A.; Busija, D.W.
Cloning and characterization of cyclooxygenase-1b (putative cyclooxygenase-3) in rat
J. Pharmacol. Exp. Ther.
313
668-676
2005
Rattus norvegicus (Q63921)
Manually annotated by BRENDA team
Giannoulias, D.; Haluska, G.J.; Gravett, M.G.; Sadowsky, D.W.; Challis, J.R.; Novy, M.J.
Localization of prostaglandin H synthase, prostaglandin dehydrogenase, corticotropin releasing hormone and glucocorticoid receptor in rhesus monkey fetal membranes with labor and in the presence of infection
Placenta
26
289-297
2005
Macaca mulatta
Manually annotated by BRENDA team
Gupta, K.; Selinsky, B.S.; Loll, P.J.
2.0 A structure of prostaglandin H2 synthase-1 reconstituted with a manganese porphyrin cofactor
Acta crystallogr. Sect. D
62
151-156
2006
Ovis aries
Manually annotated by BRENDA team
Rogge, C.E.; Ho, B.; Liu, W.; Kulmacz, R.J.; Tsai, A.L.
Role of Tyr348 in Tyr385 radical dynamics and cyclooxygenase inhibitor interactions in prostaglandin H synthase-2
Biochemistry
45
523-532
2006
Homo sapiens
Manually annotated by BRENDA team
Chubb, A.J.; Fitzgerald, D.J.; Nolan, K.B.; Moman, E.
The productive conformation of prostaglandin G2 at the peroxidase site of prostaglandin endoperoxide H synthase: docking, molecular dynamics, and site-directed mutagenesis studies
Biochemistry
45
811-820
2006
Homo sapiens
Manually annotated by BRENDA team
Tsaplina, L.A.; Karatasso, Y.O.; Filimonov, I.S.; Vrzheshch, P.V.
Kinetic mechanism of the bifunctional enzyme prostaglandin-H-synthase. Effect of electron donors on the cyclooxygenase reaction
Biochemistry (Moscow)
71
1247-1255
2006
Ovis aries (P05979), Ovis aries (P79208)
Manually annotated by BRENDA team
Winnall, W.R.; Ali, U.; Obryan, M.K.; Hirst, J.J.; Whiley, P.A.; Muir, J.A.; Hedger, M.P.
Constitutive expression of prostaglandin-endoperoxide synthase 2 by somatic and spermatogenic cells is responsible for prostaglandin E2 production in the adult rat testis
Biol. Reprod.
76
759-768
2007
Rattus norvegicus
Manually annotated by BRENDA team
Zhang, D.; Wood, C.E.
Neuronal prostaglandin endoperoxide synthase 2 responses to oxygen and glucose deprivation are mediated by mitogen-activated protein kinase ERK1/2
Brain Res.
1060
100-107
2005
Homo sapiens (P35354)
Manually annotated by BRENDA team
Censarek, P.; Freidel, K.; Hohlfeld, T.; Schroer, K.; Weber, A.A.
Human cyclooxygenase-1b is not the elusive target of acetaminophen
Eur. J. Pharmacol.
551
50-53
2006
Homo sapiens
Manually annotated by BRENDA team
Liu, W.; Cao, D.; Oh, S.F.; Serhan, C.N.; Kulmacz, R.J.
Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases
FASEB J.
20
1097-1108
2006
Ovis aries, Homo sapiens (P23219), Homo sapiens (P35354), Salvelinus fontinalis (Q9PTN3), Salvelinus fontinalis (Q9PW89), Salvelinus fontinalis
Manually annotated by BRENDA team
Jeng, W.; Ramkissoon, A.; Parman, T.; Wells, P.G.
Prostaglandin H synthase-catalyzed bioactivation of amphetamines to free radical intermediates that cause CNS regional DNA oxidation and nerve terminal degeneration
FASEB J.
20
638-650
2006
Mus musculus
Manually annotated by BRENDA team
Cabrera, R.A.; Dozier, B.L.; Duffy, D.M.
Prostaglandin-endoperoxide synthase (PTGS1 and PTGS2) expression and prostaglandin production by normal monkey ovarian surface epithelium
Fertil. Steril.
86 Suppl 4
1088-1096
2006
Macaca fascicularis
Manually annotated by BRENDA team
Trostchansky, A.; Odonnell, V.B.; Goodwin, D.C.; Landino, L.M.; Marnett, L.J.; Radi, R.; Rubbo, H.
Interactions between nitric oxide and peroxynitrite during prostaglandin endoperoxide H synthase-1 catalysis: A free radical mechanism of inactivation
Free Radic. Biol. Med.
42
1029-1038
2007
Ovis aries
Manually annotated by BRENDA team
MirAfzali, Z.; Leipprandt, J.R.; McCracken, J.L.; DeWitt, D.L.
Topography of the prostaglandin endoperoxide H2 synthase-2 in membranes
J. Biol. Chem.
281
28354-28364
2006
Homo sapiens
Manually annotated by BRENDA team
Deeb, R.S.; Hao, G.; Gross, S.S.; Laine, M.; Qiu, J.H.; Resnick, B.; Barbar, E.J.; Hajjar, D.P.; Upmacis, R.K.
Heme catalyzes tyrosine 385 nitration and inactivation of prostaglandin H2 synthase-1 by peroxynitrite
J. Lipid Res.
47
898-911
2006
Ovis aries
Manually annotated by BRENDA team
Reininger, E.A.; Bauer, R.
Prostaglandin-H-synthase (PGHS)-1 and -2 microtiter assays for the testing of herbal drugs and in vitro inhibition of PGHS-isoenzyms by polyunsaturated fatty acids from Platycodi radix
Phytomedicine
13
164-169
2006
Ovis aries (P05979), Ovis aries (P79208)
Manually annotated by BRENDA team
Sheldrick, E.L.; Derecka, K.; Marshall, E.; Chin, E.C.; Hodges, L.; Wathes, D.C.; Abayasekara, D.R.; Flint, A.P.
Peroxisome-proliferator-activated receptors and the control of levels of prostaglandin-endoperoxide synthase 2 by arachidonic acid in the bovine uterus
Biochem. J.
406
175-183
2007
Bos taurus (O62698), Bos taurus
Manually annotated by BRENDA team
Gersting, J.; Schaub, C.E.; Keller-Wood, M.; Wood, C.E.
Inhibition of brain prostaglandin endoperoxide synthase-2 prevents the preparturient increase in fetal adrenocorticotropin secretion in the sheep fetus
Endocrinology
149
4128-4136
2008
Ovis aries (P05979), Ovis aries (P79208), Ovis aries
Manually annotated by BRENDA team
Tsai, A.L.; Kulmacz, R.J.
Prostaglandin H synthase: Resolved and unresolved mechanistic issues
Arch. Biochem. Biophys.
493
103-124
2010
Ovis aries (P05979), Homo sapiens (P23219), Homo sapiens (P35354)
Manually annotated by BRENDA team
Goncalves, L.L.; Ramkissoon, A.; Wells, P.G.
Prostaglandin H synthase-1-catalyzed bioactivation of neurotransmitters, their precursors, and metabolites: oxidative DNA damage and electron spin resonance spectroscopy studies
Chem. Res. Toxicol.
22
842-852
2009
Ovis aries (P05979)
Manually annotated by BRENDA team
Seo, H.; Kim, M.; Choi, Y.; Lee, C.K.; Ka, H.
Analysis of lysophosphatidic acid (LPA) receptor and LPA-induced endometrial prostaglandin-endoperoxide synthase 2 expression in the porcine uterus
Endocrinology
149
6166-6175
2008
Sus scrofa
Manually annotated by BRENDA team
Liu, J.; Park, E.S.; Jo, M.
Runt-related transcription factor 1 regulates luteinized hormone-induced prostaglandin-endoperoxide synthase 2 expression in rat periovulatory granulosa cells
Endocrinology
150
3291-3300
2009
Rattus norvegicus
Manually annotated by BRENDA team
Enami, Y.; Bandi, S.; Kapoor, S.; Krohn, N.; Joseph, B.; Gupta, S.
Hepatic stellate cells promote hepatocyte engraftment in rat liver after prostaglandin-endoperoxide synthase inhibition
Gastroenterology
136
2356-2364
2009
Rattus norvegicus (P35355), Rattus norvegicus (Q63921)
Manually annotated by BRENDA team
Gersting, J.A.; Schaub, C.E.; Wood, C.E.
Development of prostaglandin endoperoxide synthase expression in the ovine fetal central nervous system and pituitary
Gene Expr. Patterns
9
603-611
2009
Ovis aries (P05979), Ovis aries (P79208), Ovis aries
Manually annotated by BRENDA team
Ilyina, A.; Huerta-Guel, P.; Martinez-Hernandez, J.; Rodriguez-Martinez, J.; Gorokhovsky, A.
Stability and activity of bovine prostaglandin H synthase immobilized on Opuntia imbricata (coyonoxtle)
J. Mol. Catal. B
51
1-9
2008
Bos taurus
-
Manually annotated by BRENDA team
Kawakami, Y.; Nakamura, T.; Hosokawa, T.; Suzuki-Yamamoto, T.; Yamashita, H.; Kimoto, M.; Tsuji, H.; Yoshida, H.; Hada, T.; Takahashi, Y.
Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms
Prostaglandins Leukot. Essent. Fatty Acids
80
239-245
2009
Ovis aries (P05979), Ovis aries (P79208), Homo sapiens (P23219), Homo sapiens (P35354), Homo sapiens
Manually annotated by BRENDA team
Gillio-Meina, C.; Phang, S.H.; Mather, J.P.; Knight, B.S.; Kennedy, T.G.
Expression patterns and role of prostaglandin-endoperoxide synthases, prostaglandin E synthases, prostacyclin synthase, prostacyclin receptor, peroxisome proliferator-activated receptor delta and retinoid x receptor alpha in rat endometrium during artificially-induced decidualization
Reproduction
137
537-552
2009
Rattus norvegicus (P35355), Rattus norvegicus (Q63921)
Manually annotated by BRENDA team
Bedi, G.; Tonzibo, Z.; Oussou, K.; Choppard, C.; Mahy, J.; NGuessan, T.
Effect of essential oil of chromoleana odorata (asteraceae) from ivory coast, on cyclooxygenase function of prostagladin-H synthase activity
Afr. J. Pharm. Pharmacol.
4
535-538
2010
Ovis aries
-
Manually annotated by BRENDA team
Trushkin, N.A.; Filimonov, I.S.; Vrzheshch, P.V.
Inhibition of cyclooxygenase activity of prostaglandin-H-synthase by excess substrate (molecular oxygen)
Biochemistry (Moscow)
75
1368-1373
2010
Ovis aries
Manually annotated by BRENDA team
Lee, C.J.; Goncalves, L.L.; Wells, P.G.
Embryopathic effects of thalidomide and its hydrolysis products in rabbit embryo culture: evidence for a prostaglandin H synthase (PHS)-dependent, reactive oxygen species (ROS)-mediated mechanism
FASEB J.
25
2468-2483
2011
Oryctolagus cuniculus
Manually annotated by BRENDA team
Ramkissoon, A.; Wells, P.G.
Human prostaglandin H synthase (hPHS)-1- and hPHS-2-dependent bioactivation, oxidative macromolecular damage, and cytotoxicity of dopamine, its precursor, and its metabolites
Free Radic. Biol. Med.
50
295-304
2011
Homo sapiens
Manually annotated by BRENDA team
Vecchio, A.J.; Simmons, D.M.; Malkowski, M.G.
Structural basis of fatty acid substrate binding to cyclooxygenase-2
J. Biol. Chem.
285
22152-22163
2010
Mus musculus (Q05769), Mus musculus
Manually annotated by BRENDA team
Liu, W.; Poole, E.M.; Ulrich, C.M.; Kulmacz, R.J.
Polymorphic human prostaglandin H synthase-2 proteins and their interactions with cyclooxygenase substrates and inhibitors
Pharmacogenomics J.
11
337-347
2010
Homo sapiens
Manually annotated by BRENDA team
Ramkissoon, A.; Wells, P.G.
Human prostaglandin H synthase (hPHS)-1 and hPHS-2 in amphetamine analog bioactivation, DNA oxidation, and cytotoxicity
Toxicol. Sci.
120
154-162
2011
Homo sapiens
Manually annotated by BRENDA team
Varvas, K.; Kasvandik, S.; Hansen, K.; Jaerving, I.; Morell, I.; Samel, N.
Structural and catalytic insights into the algal prostaglandin H synthase reveal atypical features of the first non-animal cyclooxygenase
Biochim. Biophys. Acta
1831
863-871
2013
Agarophyton vermiculophyllum (I6VVK9), Agarophyton vermiculophyllum, Coccotylus truncatus (I6VCP8), Coccotylus truncatus
Manually annotated by BRENDA team
Joseph, T.; Zalenskaya, I.A.; Sawyer, L.C.; Chandra, N.; Doncel, G.F.
Seminal plasma induces prostaglandin-endoperoxide synthase (PTGS) 2 expression in immortalized human vaginal cells: involvement of semen prostaglandin E2 in PTGS2 upregulation
Biol. Reprod.
88
13
2013
Homo sapiens (P35354), Homo sapiens
Manually annotated by BRENDA team
Tsikas, D.; Suchy, M.T.; Niemann, J.; Tossios, P.; Schneider, Y.; Rothmann, S.; Gutzki, F.M.; Froelich, J.C.; Stichtenoth, D.O.
Glutathione promotes prostaglandin H synthase (cyclooxygenase)-dependent formation of malondialdehyde and 15(S)-8-iso-prostaglandin F2?
FEBS Lett.
586
3723-3730
2012
Homo sapiens (P23219), Homo sapiens (P35354)
Manually annotated by BRENDA team
Zerani, M.; Catone, G.; Betti, G.; Parillo, F.
Immunopresence and functional activity of prostaglandin-endoperoxide synthases and nitric oxide synthases in bovine corpora lutea during diestrus
Folia Morphol. (Praha)
72
36-40
2013
Bos taurus (O62664), Bos taurus (O62698), Bos taurus
Manually annotated by BRENDA team
Trostchansky, A.; Bonilla, L.; Thomas, C.P.; ODonnell, V.B.; Marnett, L.J.; Radi, R.; Rubbo, H.
Nitroarachidonic acid, a novel peroxidase inhibitor of prostaglandin endoperoxide H synthases 1 and 2
J. Biol. Chem.
286
12891-12900
2011
Homo sapiens (P23219), Homo sapiens (P35354), Homo sapiens
Manually annotated by BRENDA team
Brant, K.A.; Leikauf, G.D.
Dysregulation of FURIN by prostaglandin-endoperoxide synthase 2 in lung epithelial NCI-H292 cells
Mol. Carcinog.
53
192-200
2012
Homo sapiens (P35354)
Manually annotated by BRENDA team
Kukk, K.; Jaerving, R.; Samel, N.
Purification and characterization of the recombinant human prostaglandin H synthase-2 expressed in Pichia pastoris
Protein Expr. Purif.
83
182-189
2012
Homo sapiens (P23219), Homo sapiens (P35354), Homo sapiens
Manually annotated by BRENDA team
Gupta, K.; Selinsky, B.S.
Bacterial and algal orthologs of prostaglandin H2 synthase novel insights into the evolution of an integral membrane protein
Biochim. Biophys. Acta
1848
83-94
2015
Ovis aries (P05979)
Manually annotated by BRENDA team
Piranda, D.; Abreu, R.; Freitas-Alves, D.; de Carvalho, M.; Vianna-Jorge, R.
Modulation of the prostaglandin-endoperoxide synthase 2 gene expression by variant haplotypes Influence of the 3'-untranslated region
Braz. J. Med. Biol. Res.
51
e6546
2018
Homo sapiens
Manually annotated by BRENDA team
Das, A.; Gogoi, U.; Kalita, J.; Sandilya, S.
Molecular docking study of a series of substituted xanthone derivatives as novel COX-2 inhibitors targeting prostaglandin endoperoxide synthase-2
Curr. Enzyme Inhib.
12
195-204
2016
Mus musculus (Q05769)
-
Manually annotated by BRENDA team
Herington, J.L.; OBrien, C.; Robuck, M.F.; Lei, W.; Brown, N.; Slaughter, J.C.; Paria, B.C.; Mahadevan-Jansen, A.; Reese, J.
Prostaglandin-endoperoxide synthase 1 mediates the timing of parturition in mice despite unhindered uterine contractility
Endocrinology
159
490-505
2017
Mus musculus
Manually annotated by BRENDA team
Li, N.; Wang, Q.; Zhu, T.; Qiao, L.; Zhang, F.; Mi, R.; Wang, B.; Chen, L.; Gu, J.; Lu, Y.; Zheng, Q.
In vitro functional characterization of prostaglandin-endoperoxide synthase 2 during chondrocyte hypertrophic differentiation
Oncotarget
7
36280-36292
2016
Mus musculus
Manually annotated by BRENDA team
Rebordao, M.R.; Galvao, A.; Pinto-Bravo, P.; Pinheiro, J.; Gamboa, S.; Silva, E.; Mateus, L.; Ferreira-Dias, G.
Endometrial prostaglandin synthases, ovarian steroids, and oxytocin receptors in mares with oxytocin-induced luteal maintenance
Theriogenology
87
193-204
2017
Equus caballus
Manually annotated by BRENDA team
El-Nagar, M.K.S.; Abdu-Allah, H.H.M.; Salem, O.I.A.; Kafafy, A.N.; Farghaly, H.S.M.
Novel N-substituted 5-aminosalicylamides as dual inhibitors of cyclooxygenase and 5-lipoxygenase enzymes Synthesis, biological evaluation and docking study
Bioorg. Chem.
78
80-93
2018
Homo sapiens, Ovis aries
Manually annotated by BRENDA team
Park, N.Y.; Im, S.; Jiang, Q.
Different forms of vitamin E and metabolite 13-carboxychromanols inhibit cyclooxygenase-1 and its catalyzed thromboxane in platelets, and tocotrienols and 13-carboxychromanols are competitive inhibitors of 5-lipoxygenase
J. Nutr. Biochem.
100
108884
2022
Homo sapiens
Manually annotated by BRENDA team