1.14.20.1: deacetoxycephalosporin-C synthase
This is an abbreviated version!
For detailed information about deacetoxycephalosporin-C synthase, go to the full flat file.
Word Map on EC 1.14.20.1
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1.14.20.1
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clavuligerus
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chrysogenum
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acremonium
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isopenicillin
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penicillium
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beta-lactams
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epimerase
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cephamycins
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cephalosporium
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ring-expansion
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7-aminodeacetoxycephalosporanic
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pcbab
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ironii
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cephem
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lactamdurans
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synthesis
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7-adca
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2-oxoglutarate-dependent
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cephalexin
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carbenicillin
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doacs
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biotechnology
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medicine
- 1.14.20.1
- clavuligerus
- chrysogenum
- acremonium
- isopenicillin
- penicillium
- beta-lactams
-
epimerase
-
cephamycins
- cephalosporium
-
ring-expansion
-
7-aminodeacetoxycephalosporanic
-
pcbab
-
ironii
-
cephem
- lactamdurans
- synthesis
-
7-adca
-
2-oxoglutarate-dependent
- cephalexin
- carbenicillin
-
doacs
- biotechnology
- medicine
Reaction
Synonyms
acDAOC/DACS, cefE, cefEF, Cephalosporin biosynthesis expandase/hydroxylase, DAOC synthase, DAOC/DAC synthase, DAOC/DACS, DAOCS, deacetoxy/deacetylcephalosporin C synthase, deacetoxycephalosporin C synthase, deacetoxycephalosporin-C synthase, deacetoxycephalosporin-C synthetase, deacetoxycephalosporin/deacetylcephalosporin C synthase, expandase, expendase, penicillin N expandase, scDAOCS
ECTree
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Metals Ions
Metals Ions on EC 1.14.20.1 - deacetoxycephalosporin-C synthase
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Fe2+
Fe3+
Iron
additional information
Fe2+
dependent on, iron cofactor is bound by D184, H186, and H244
Fe2+
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required, cannot be substituted by other divalent metal ions
Fe2+
bound to the active site, forms a reactive iron-oxygen reaction intermediate during catalysis, complex structure in native and His-tagged enzyme
Fe2+
acts as cofactor, the iron-binding centre in this family of enzymes essentially provides versatility and flexibility in catalysing a variety of oxidative reactions that include desaturation, ring expansion, and hydroxylation
Fe2+
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required, cannot be substituted by other divalent metal ions
Fe2+
required, residues M180 and I305 are involved in Fe2+-binding
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Fe2+ cannot be replaced by Mg2+, Mn2+, Ca2+, Co2+, Cu2+, Ni2+ or Zn2+
additional information
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Fe2+ cannot be replaced by Mg2+, Mn2+, Ca2+, Co2+, Cu2+, Ni2+ or Zn2+