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1.14.19.6: acyl-CoA (9+3)-desaturase

This is an abbreviated version!
For detailed information about acyl-CoA (9+3)-desaturase, go to the full flat file.

Word Map on EC 1.14.19.6

Reaction

oleoyl-CoA
+ 2 ferrocytochrome b5 +
O2
 + 2 H+ =
linoleoyl-CoA
 + 2 ferricytochrome b5 + 2 H2O

Synonyms

acyl-CoA (9+3)-desaturase, acyl-lipid DELTA12-desaturase, Cofad2-2, CSFAD2A, D12Des, DELTA 12 desaturase, delta 12 fatty acid desaturases, delta-12 fatty acid desaturase, delta-12 fatty acid desaturase 2, DELTA12 acyl-lipid desaturase, DELTA12 desaturase, DELTA12 FAD, DELTA12 fatty acid desaturase, DELTA12 oleate hydroxylase, DELTA12(omega6)-desaturase, DELTA12-acyl-lipid desaturase, DELTA12-desaturase, DELTA12-desaturase system, DELTA12-FAD, DELTA12-fatty acid desaturase, DELTA12-fatty acyl-CoA desaturase, DELTA12des, DELTA12DS, Des12, DesA, egFAD2, FAD-2, FAD2, FAD2-2, FAD2A, FADS1, FADS2, FAH, FAT-2, fatty acid desaturase-2, Fm2, KlFAD2, Le-FAD2, LKFAD15, microsomal Delta-12 fatty acid desaturase, microsomal delta-12 oleate desaturase, microsomal oleate desaturase, microsomal omega-6 fatty acid desaturase, oleoyl coenzyme A desaturase, oleoyl-CoA DELTA12 desaturase, oleoyl-DELTA12 desaturase, oleoyl-DELTA12/linoleoyl-DELTA3 desaturase, omega-6 fatty acid desaturase, PtFAD2, PtFAD6, seed-specific delta-12 fatty acid desaturase 2

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.6 acyl-CoA (9+3)-desaturase

Natural Substrates Products

Natural Substrates Products on EC 1.14.19.6 - acyl-CoA (9+3)-desaturase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(Z)-9-tetradecenoic acid + ?
tetradec-9,12-dienoic acid
show the reaction diagram
-
biosynthetic pathway for producing the sex pheromone component (Z,E)-9,12-tetradecadienyl acetate in moths involves a DELTA12 desaturase
-
-
?
1-oleoyl-2-acyl-[glycerolipid] + reduced ferredoxin [iron-sulfur] cluster + O2 + H+
1-linoleoyl-2-acyl-[glycerolipid] + oxidized ferredoxin [iron-sulfur] cluster + H2O
show the reaction diagram
cis-9-octadecenoic acid + reduced acceptor + O2
cis,cis-9,12-octadecadienoic acid + acceptor + 2 H2O
show the reaction diagram
-
PtFAD2 is involved in the biosynthesis of eicosapentaenoic acid
-
-
?
eicosenoic acid + reduced acceptor + O2
20:2DELTA11,14 + acceptor + H2O
show the reaction diagram
62% conversion
-
-
?
oleic acid + ?
linoleic acid + ?
show the reaction diagram
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
show the reaction diagram
oleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
linoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
oleoyl-CoA + 2 reduced acceptor + O2 + 2 H+
linoleoyl-CoA + 2 acceptor + 2 H2O
show the reaction diagram
oleoyl-CoA + reduced acceptor + O2
9,12-octadecadienoyl-CoA + acceptor + 2 H2O
show the reaction diagram
oleoyl-CoA + reduced acceptor + O2
octadec-9,11-dienoyl-CoA + acceptor + 2 H2O
show the reaction diagram
-
the DELTA12 desaturase provides the key step for the cockroach to become nutritionally independent of dietary lipid and to synthesize eicosanoids de novo
-
-
?
palmitoleic acid + reduced acceptor + O2
(9Z,12Z)-hexadeca-9,12-dienoic acid + acceptor + H2O
show the reaction diagram
palmitoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
(9Z,12Z)-hexadeca-9,12-dienoyl-CoA + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
-
-
?
stearolic acid + reduced acceptor + O2
trans-12-octadecen-9-ynoic acid + acceptor + H2O
show the reaction diagram
additional information
?
-